Is the round window membrane a portal for bacterial toxins? A putative mechanism for sensorineural hearing loss following acute otitis media

1998 ◽  
Vol 23 (3) ◽  
pp. 273-273
Author(s):  
George ◽  
Comis
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Otitis Media ◽  
Round Window ◽  
Acute Otitis Media ◽  
Bacterial Toxins ◽  
Sensorineural Hearing ◽  
Round Window Membrane ◽  
Putative Mechanism

scholarly journals Bacterial Cytolysin Perturbs Round Window Membrane Permeability Barrier In Vivo: Possible Cause of Sensorineural Hearing Loss in Acute Otitis Media

1998 ◽  
Vol 66 (1) ◽  
pp. 343-346 ◽  
Author(s):  
Frank Engel ◽  
Rosemarie Blatz ◽  
Reinhard Schliebs ◽  
Michael Palmer ◽  
Sucharit Bhakdi
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Middle Ear ◽  
Round Window ◽  
Acute Otitis Media ◽  
Sensorineural Hearing ◽  
Round Window Membrane ◽  
Permeability Barrier ◽  
Streptolysin O

ABSTRACT The passage of radioiodinated streptolysin-O (SLO) and albumin through the round window membrane (RWM) was studied in vivo. When applied to the middle ear, SLO became quantitatively entrapped in this compartment and no passage to the cochlea occurred. However, flux of radioiodinated albumin through the toxin-damaged RWM was observed. We propose that the passage of noxious macromolecules, such as proteases, from a purulent middle-ear effusion may be facilitated by pore-forming toxins, resulting in cochlear damage and sensorineural hearing loss.

scholarly journals Cochlear Implantation Following Explorative Tympanotomy in Patients With Sudden Sensorineural Hearing Loss: Surgical Features and Audiological Outcomes

2021 ◽  
pp. 014556132110091
Author(s):  
Robin Rupp ◽  
Joachim Hornung ◽  
Matthias Balk ◽  
Matti Sievert ◽  
Sarina Müller ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Connective Tissue ◽  
Sensorineural Hearing Loss ◽  
Cochlear Implantation ◽  
Round Window ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Round Window Membrane ◽  
Hearing Results ◽  
Round Window Niche

Objective: To investigate the anatomical status of the round window niche and hearing outcome of cochlear implantation (CI) after explorative tympanotomy (ExT) with sealing of the round window membrane in patients with sudden sensorineural hearing loss at a tertiary referral medical center. Methods: Between January 1, 2007, and July 30, 2020, 1602 patients underwent CI at our department. Out of these, all patients previously treated by ExT with sealing of the round window membrane because of unilateral sudden hearing loss were included in the study. A retrospective chart review was conducted concerning method of round window membrane sealing, intraoperative findings during CI, postoperative imaging, and hearing results. Results: Twenty one patients (9 females; 8 right ears; 54.3 years [± 12.9 years]) underwent ExT with sealing of the round window membrane with subsequent CI after 26.6 months (± 32.9 mo) on average. During CI, in 76% of cases (n = 16), the round window niche was blocked by connective tissue due to the previous intervention but could be removed completely in all cases. The connective tissue itself and its removal had no detrimental effects on the round window membrane. Postoperative computed tomography scan showed no electrode dislocation. Mean postoperative word recognition score after 3 months was 57.4% (± 17.2%) and improved significantly to 73.1% (± 16.4%, P = .005) after 2 years. Conclusion: Performing CI after preceding ExT, connective tissue has to be expected blocking the round window niche. Remaining tissue can be removed safely and does not alter the round window membrane allowing for a proper electrode insertion. Short- and long-term hearing results are satisfactory. Consequently, ExT with sealing of the round window membrane in patients with sudden sensorineural hearing loss does not impede subsequent CI that can still be performed safely.

scholarly journals Sensorineural hearing loss in the acute phase of a single episode of acute otitis media

2020 ◽  
Vol 86 (6) ◽  
pp. 767-773 ◽  
Author(s):  
Ana Luiza Papi Kasemodel ◽  
Ludmilla Emília Martins Costa ◽  
Rafael da Costa Monsanto ◽  
Andreza Tomaz ◽  
Norma de Oliveira Penido
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Otitis Media ◽  
Acute Phase ◽  
Acute Otitis Media ◽  
Sensorineural Hearing ◽  
Single Episode

Acute otitis media associated bilateral sudden hearing loss: case report and literature review

2017 ◽  
Vol 131 (S2) ◽  
pp. S57-S61 ◽  
Author(s):  
A Smith ◽  
I Gutteridge ◽  
D Elliott ◽  
M Cronin
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Sensorineural Hearing Loss ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Definitive Treatment ◽  
Published Evidence ◽  
Increased Risk

AbstractBackground:Sudden sensorineural hearing loss is a rare otological condition with potential for dire outcomes including permanent hearing loss. Although the majority of cases are deemed idiopathic, bilateral sudden sensorineural hearing loss represents a rare subset typically related to systemic conditions, with higher morbidity and mortality. A controversial association with acute otitis media has been reported, with few bilateral cases published in the literature.Case report:A very rare case of bilateral sudden sensorineural hearing loss associated with acute otitis media is described, with a review of the literature.Conclusion:The limited evidence available suggests that acute otitis media with tinnitus and/or bacterial pathology may have an increased risk of sudden sensorineural hearing loss, which is consistent with the case described. Although there is no sufficiently powered published evidence to provide definitive treatment guidelines, the literature reviewed suggests that early myringotomy and antibiotics may greatly improve treatment outcomes.

scholarly journals Sensorineural Hearing Loss in Acute Otitis Media

2003 ◽  
Vol 46 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Teiji Tanahashi ◽  
Shigeisa Matsumuro
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Sensorineural Hearing
Sign in / Sign up

Export Citation Format

Share Document