The HCV National Register: towards informing the natural history of hepatitis C infection in the UK

2000 ◽  
Vol 7 (6) ◽  
pp. 420-427 ◽  
Author(s):  
H. E. Harris ◽  
M. E. Ramsay ◽  
J. Heptonstall ◽  
K. Soldan ◽  
K. P. Eldridge ◽  
...  
2010 ◽  
Vol 53 (2) ◽  
pp. 245-251 ◽  
Author(s):  
Ava John-Baptiste ◽  
Murray Krahn ◽  
Jenny Heathcote ◽  
Audery Laporte ◽  
George Tomlinson

2011 ◽  
Vol 140 (10) ◽  
pp. 1830-1837 ◽  
Author(s):  
H. E. HARRIS ◽  
A. COSTELLA ◽  
G. AMIRTHALINGAM ◽  
G. ALEXANDER ◽  
M. E. B. RAMSAY ◽  
...  

SUMMARYIn a cohort of 272 treatment-naive individuals with chronic hepatitis C infection acquired on a known date who were enrolled in the UK HCV National Register, a progressive improvement in response to treatment was found with the evolution of antiviral therapies from 20% (25/122) for interferon monotherapy to 63% (55/88) for pegylated interferon+ribavirin therapy. Multivariable analysis results showed increasing age to be associated with poorer response to therapy [odds ratio (OR) 0·84, 95% confidence interval (CI) 0·72–0·99, P=0·03] whereas time since infection was not associated with response (OR 0·93, 95% CI 0·44–1·98, P=0·85). Other factors significantly associated with a positive response were non-type 1 genotype (P<0·0001) and combination therapies (P<0·0001). During the first two decades of chronic HCV infection, treatment at a younger age was found to be more influential in achieving a sustained viral response than treating earlier in the course of infection.


Hepatology ◽  
2014 ◽  
Vol 61 (1) ◽  
pp. 88-97 ◽  
Author(s):  
Tamer Abdelrahman ◽  
Joseph Hughes ◽  
Janice Main ◽  
John McLauchlan ◽  
Mark Thursz ◽  
...  

Transfusion ◽  
2006 ◽  
Vol 46 (8) ◽  
pp. 1360-1366 ◽  
Author(s):  
Dirk Posthouwer ◽  
Kathelijn Fischer ◽  
Karel J. van Erpecum ◽  
Eveline P. Mauser-Bunschoten

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