Transfusion-related Acute Lung Injury during Liver Transplantation: A Scoping Review

2021 ◽  
Author(s):  
ManNoj H. Iyer ◽  
Julia E. Kumar ◽  
Nicolas Kumar ◽  
Leonid Gorelik ◽  
Nasir Hussain ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Scoping Review

scholarly journals Propofol Activation of the Nrf2 Pathway Is Associated with Amelioration of Acute Lung Injury in a Rat Liver Transplantation Model

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Weifeng Yao ◽  
Gangjian Luo ◽  
Guosong Zhu ◽  
Xinjin Chi ◽  
Ailan Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Water Content ◽  
High Dose ◽  
Lung Pathology ◽  
Lung Water ◽  
Sod Activity ◽  
Nrf2 Pathway ◽  
Lung Water Content

Objective. This study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment.Method. Adult male Sprague-Dawley rats were divided into five groups based on the random number table. Lung pathology was observed by optical microscopy. Lung water content was assessed by wet/dry ratio, and PaO2was detected by blood gas analysis. The contents of H2O2, MDA, and SOD activity were determined by ELISA method, and the expression of HO-1, NQO1, Keap1, and nuclear Nrf2 was assayed by western blotting.Results. Compared with saline-treated model group, both propofol and N-acetylcysteine pretreatment can reduce the acute lung injury caused by orthotopic autologous liver transplantation (OALT), decrease the lung injury scores, lung water content, and H2O2and MDA levels, and improve the arterial PaO2and SOD activity. Furthermore, propofol (but not N-acetylcysteine) pretreatment especially in high dose inhibited the expression of Keap1 and induced translocation of Nrf2 into the nucleus to further upregulate the expression of HO-1 and NQO1 downstream.Conclusion. Pretreatment with propofol is associated with attenuation of OALT-induced ALI, and the Nrf2 pathway is involved in the antioxidative processes.

Stabilizing mast cells improves acute lung injury after orthotopic liver transplantation via promotion of apoptosis in polymorphonuclear neutrophils

2020 ◽  
Author(s):  
Chaojin Chen ◽  
Zheng Zhang ◽  
Fang Tan ◽  
Fanbing Meng ◽  
Lifei Lai ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Mast Cells ◽  
Lung Injury ◽  
Orthotopic Liver Transplantation ◽  
Inflammatory Cells ◽  
Pulmonary Complications ◽  
Polymorphonuclear Neutrophils ◽  
Inflammatory Factor ◽  
Tnf Α

Aims: Postoperative pulmonary complications including acute lung injury (ALI) and acute respiratory distress syndrome have contributed to the mortality and morbidity of orthotopic liver transplantation (OLT) with unclear mechanisms. Mast cells (MCs) and polymorphonuclear neutrophils (PMNs) are the main inflammatory cells and participants in the process of ALI. The present study was designed to investigate the role of MCs and PMNs and their potential relation to ALI following OLT. Main Methods: Rat orthotopic autologous liver transplantation (OALT) model was designed to determine lung injury at different time points after liver reperfusion. We also evaluated the function of MCs and the effect of TNF-α and tryptase on ALI and PMN apoptosis in rats subjected to OALT. Histological scores and inflammatory factor levels as well as PMN apoptosis were measured. Key findings: Rats suffered from ALI after OALT, which was demonstrated with collapse of pulmonary architecture, pulmonary edema, and infiltration of inflammatory cells in alveolar and interstitial spaces, as well as increased levels of pro-inflammatory cytokines. ALI maximized at 8 h after OALT. However, PMN apoptosis lagged behind the pulmonary injury and maximized at 16 h after OALT, when the acute inflammation resolution initiated. MC stabilization, and tryptase and TNF-α inhibitors could significantly decrease the lung pathophysiologic scores accompanied with an increase in PMN apoptosis. Significance: ALI after OLT was associated with MC activation and PMN apoptosis. The ALI progression might be affected by delayed PMN apoptosis, which was related to MC activation. Induction of PMN apoptosis might alleviate ALI after OALT.

Ulinastatin prevents acute lung injury led by liver transplantation

2015 ◽  
Vol 193 (2) ◽  
pp. 841-848 ◽  
Author(s):  
Gang-Jian Luo ◽  
Wei-Feng Yao ◽  
Ye He ◽  
Chen-Fang Luo ◽  
Xiao-Yun Li ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Lung Injury

SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction

2017 ◽  
Vol 108 ◽  
pp. 542-553 ◽  
Author(s):  
Weifeng Yao ◽  
Haobo Li ◽  
Gangjian Luo ◽  
Xiang Li ◽  
Chaojin Chen ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Lung Injury

scholarly journals Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation

2011 ◽  
Vol 17 (2) ◽  
pp. 149-158 ◽  
Author(s):  
Alexander B. Benson ◽  
James R. Burton ◽  
Gregory L. Austin ◽  
Scott W. Biggins ◽  
Michael A. Zimmerman ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Infection Risk ◽  
Differential Effects ◽  
Red Blood Cell Transfusions

Platelet Transfusion During Liver Transplantation Is Associated with Increased Postoperative Mortality Due to Acute Lung Injury

2009 ◽  
Vol 108 (4) ◽  
pp. 1083-1091 ◽  
Author(s):  
Ilona T. A. Pereboom ◽  
Marieke T. de Boer ◽  
Elizabeth B. Haagsma ◽  
Herman G. D. Hendriks ◽  
Ton Lisman ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Platelet Transfusion ◽  
Postoperative Mortality

Transfusion-Related Acute Lung Injury (TRALI) and Transfusion-Associated Circulatory Overload (TACO) in Liver Transplantation: A Case Report and Focused Review

2017 ◽  
Vol 22 (2) ◽  
pp. 180-190 ◽  
Author(s):  
Natalie K. Smith ◽  
Sang Kim ◽  
Bryan Hill ◽  
Andrew Goldberg ◽  
Samuel DeMaria ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Case Report ◽  
Lung Injury ◽  
Point Of Care ◽  
Major Vessel ◽  
Coagulation Defects ◽  
Complex Procedure ◽  
Circulatory Overload ◽  
Graft Storage

Liver transplantation (LT) is a complex procedure in a patient with multi-organ system dysfunction and coagulation defects. The surgical procedure involves dissection, major vessel manipulation, and pathophysiologic effects of graft storage and reperfusion. As a result, LT frequently involves significant hemorrhage. Subsequent massive transfusion carries high risk of transfusion-associated complications. Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are the leading causes of transfusion associated mortality. In this case report and focused review, we present data that suggest that patients undergoing liver transplantation may be at higher risk for TRALI and TACO than the general population. Anesthesiologists can play a role in decreasing these risks by increasing recognition and reporting of TRALI and TACO, using point of care testing with thromboelastography to guide and decrease transfusion, and considering alternatives to traditional blood products like solvent/detergent plasma.

Sign in / Sign up

Export Citation Format

Share Document