Intraoperative Hypotension – Physiological Basis and Future Directions

2021 ◽  
Author(s):  
Hamdy Awad ◽  
Gabriel Alcodray ◽  
Arwa Raza ◽  
Racha Boulos ◽  
Michael Essandoh ◽  
...  
Keyword(s):  
Physiological Basis ◽  
Future Directions ◽  
Intraoperative Hypotension

The Physiology of Social Pain

2020 ◽  
pp. 47-68
Author(s):  
Anita L. Vangelisti ◽  
Nicholas Brody
Keyword(s):  
Physiological Responses ◽  
Cognitive Behavioral ◽  
Neural Processing ◽  
Physical Pain ◽  
Social Pain ◽  
Physiological Basis ◽  
Future Directions ◽  
Social Basis ◽  
The Social

Social pain and physical pain have historically been conceptualized as distinct phenomena. Recent research, however, has noted several similarities between the two. The present chapter establishes the physiological basis of social pain. Further, the chapter explores the relational precedents and correlates of social pain. By synthesizing research that explores definitional elements of social pain, the reviewed literature explores the social basis of hurt. The chapter also reviews the extant research that posits similarities in the neural processing of social and physical pain. These similarities are further explained by examining findings that have emphasized parallels between cognitive, behavioral, and physiological responses to both social and physical pain. Shortcomings in the current research are reviewed, and several future directions are offered for researchers interested in the physiology of social pain.

scholarly journals Meta-analysis of the genetic loci of pigment pattern evolution in vertebrates

2022 ◽  
Author(s):  
Joel Elkin ◽  
Arnaud Martin ◽  
Virginie Courtier-Orgogozo ◽  
M. Emilia Santos
Keyword(s):  
Genetic Variants ◽  
Genetic Basis ◽  
Pigment Cell ◽  
Meta Analysis ◽  
Model Systems ◽  
Regulatory Change ◽  
Trait Variation ◽  
Physiological Basis ◽  
Future Directions ◽  
Regulatory Mutations

Vertebrate pigmentation patterns are amongst the best characterised model systems for studying the genetic basis of adaptive evolution. The wealth of available data on the genetic basis for pigmentation evolution allows for meta-analysis of trends and quantitative testing of evolutionary hypotheses. We employed Gephebase, a database of genetic variants associated with natural and domesticated trait variation, to examine trends in how cis-regulatory and coding mutations contribute to vertebrate pigmentation phenotypes, as well as factors that favour one mutation type over the other. We found that studies with lower ascertainment bias identified higher proportions of cis-regulatory mutations, and that cis-regulatory mutations were more common amongst animals harboring a higher number of pigment cell classes. We classified pigmentation traits firstly according to their physiological basis and secondly according to whether they affect colour or pattern, and identified that carotenoid-based pigmentation and variation in pattern boundaries are preferentially associated with cis-regulatory change. We also classified genes according to their developmental, cellular, and molecular functions. We found that genes implicated in upstream developmental processes had greater cis-regulatory proportions than downstream cellular function genes, and that ligands were associated with higher cis-regulatory proportions than their respective receptors. Based on these trends, we discuss future directions for research in vertebrate pigmentation evolution.

scholarly journals Potential for endocannabinoid system modulation in ocular pain and inflammation: filling the gaps in current pharmacological options

2018 ◽  
Vol 2 (4) ◽  
Author(s):  
J. Daniel Lafreniere ◽  
Melanie E.M. Kelly
Keyword(s):  
Chronic Pain ◽  
Current Knowledge ◽  
Endocannabinoid System ◽  
Ocular Pain ◽  
Physiological Basis ◽  
Future Directions ◽  
Anti Inflammatory ◽  
Neuroprotective Actions ◽  
Chronic Pain Conditions ◽  
Ocular Safety

Challenges in the management of ocular pain are an underappreciated topic. Currently available therapeutics lack both efficacy and clear guidelines for their use, with many also possessing unacceptable side effects. Promising novel agents would offer analgesic, anti-inflammatory, and possibly neuroprotective actions; have favorable ocular safety profiles; and show potential in managing neuropathic pain. Growing evidence supports a link between the endocannabinoid system (ECS) and a range of physiological and disease processes, notably those involving inflammation and pain. Both preclinical and clinical data suggest analgesic and anti-inflammatory actions of cannabinoids and ECS-modifying drugs in chronic pain conditions, including those of neuropathic origin. This review will examine existing evidence for the anatomical and physiological basis of ocular pain, specifically, ocular surface disease and the development of chronic ocular pain. The mechanism of action, efficacy, and limitations of currently available treatments will be discussed, and current knowledge related to ECS-modulation of ocular pain and inflammatory disease will be summarized. A perspective will be provided on the future directions of ECS research in terms of developing cannabinoid therapeutics for ocular pain.

scholarly journals Renal Denervation: Paradise Lost? Paradise Regained?

2018 ◽  
Vol 12 (2) ◽  
pp. 78 ◽  
Author(s):  
Deepak Padmanabhan ◽  
Ameesh Isath ◽  
Bernard Gersh ◽  
◽  
◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Denervation ◽  
Blood Pressure Reduction ◽  
Review Article ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Physiological Basis ◽  
Future Directions ◽  
Paradise Regained ◽  
Pressure Lowering

Renal denervation is a relatively recent concept whose initial promising results suffered a setback following the SYMPLICITY 3 trial, which did not show a significant blood pressure-lowering effect in comparison to sham. In this review article, we begin with the history including the physiological basis behind the concept of renal denervation. Furthermore, we review the literature in support of renal denervation, including the recently published SPYRAL HTN-OFF MED, which demonstrated significant blood pressure reduction in the absence of antihypertensive medication. We further touch upon the potential pitfalls and possible future directions of renal denervation.

On Future Directions in Pathology

1982 ◽  
Vol 40 ◽  
pp. 274-277
Author(s):  
Benjamin F. Trump ◽  
Irene K. Berezesky ◽  
Raymond T. Jones
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Clinical Pathology ◽  
Future Directions ◽  
Diagnostic Pathology ◽  
The Past ◽  
Transmission Electron ◽  
Organ Systems ◽  
The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

Meeting the Best Practice for Hearing Aid Verification in Children: Challenges and Future Directions

2019 ◽  
Vol 28 (4) ◽  
pp. 877-894
Author(s):  
Nur Azyani Amri ◽  
Tian Kar Quar ◽  
Foong Yen Chong
Keyword(s):  
Clinical Practice ◽  
Hearing Aids ◽  
Best Practice ◽  
Hearing Aid ◽  
Evidence Based ◽  
Future Directions ◽  
Major Barrier ◽  
Klang Valley ◽  
Age Range ◽  
Fitting Hearing Aids

Purpose This study examined the current pediatric amplification practice with an emphasis on hearing aid verification using probe microphone measurement (PMM), among audiologists in Klang Valley, Malaysia. Frequency of practice, access to PMM system, practiced protocols, barriers, and perception toward the benefits of PMM were identified through a survey. Method A questionnaire was distributed to and filled in by the audiologists who provided pediatric amplification service in Klang Valley, Malaysia. One hundred eight ( N = 108) audiologists, composed of 90.3% women and 9.7% men (age range: 23–48 years), participated in the survey. Results PMM was not a clinical routine practiced by a majority of the audiologists, despite its recognition as the best clinical practice that should be incorporated into protocols for fitting hearing aids in children. Variations in practice existed warranting further steps to improve the current practice for children with hearing impairment. The lack of access to PMM equipment was 1 major barrier for the audiologists to practice real-ear verification. Practitioners' characteristics such as time constraints, low confidence, and knowledge levels were also identified as barriers that impede the uptake of the evidence-based practice. Conclusions The implementation of PMM in clinical practice remains a challenge to the audiology profession. A knowledge-transfer approach that takes into consideration the barriers and involves effective collaboration or engagement between the knowledge providers and potential stakeholders is required to promote the clinical application of evidence-based best practice.

Translating Principles of Speech Science to Clinical Practice: Current and Future Trends in Craniofacial Disorders

2008 ◽  
Vol 18 (1) ◽  
pp. 31-40 ◽  
Author(s):  
David J. Zajac
Keyword(s):  
Clinical Practice ◽  
Speech Intelligibility ◽  
Current Practice ◽  
Computer Assisted ◽  
Behavioral Management ◽  
Single Word ◽  
Future Directions ◽  
Speech Science ◽  
The Impact ◽  
Opinion Article

Abstract The purpose of this opinion article is to review the impact of the principles and technology of speech science on clinical practice in the area of craniofacial disorders. Current practice relative to (a) speech aerodynamic assessment, (b) computer-assisted single-word speech intelligibility testing, and (c) behavioral management of hypernasal resonance are reviewed. Future directions and/or refinement of each area are also identified. It is suggested that both challenging and rewarding times are in store for clinical researchers in craniofacial disorders.

Renal denervation - a clinical update and future directions

VASA ◽  
2013 ◽  
Vol 42 (4) ◽  
pp. 239-251
Author(s):  
Kai Mortensen ◽  
Klaas Franzen ◽  
Michael Reppel ◽  
Joachim Weil
Keyword(s):  
Renal Denervation ◽  
Future Directions ◽  
Scientific Background

The aim of this review is to give a contemporary update on renal denervation therapy focusing particularly on the scientific background and present literature as well as on different technical approaches and potential future directions.

On the Individual

1999 ◽  
Vol 4 (4) ◽  
pp. 205-218 ◽  
Author(s):  
David Magnusson
Keyword(s):  
School Psychologist ◽  
Real Life ◽  
Psychological Research ◽  
Developmental Research ◽  
Future Directions ◽  
The 1950S ◽  
The Individual ◽  
Over Time

A description of two cases from my time as a school psychologist in the middle of the 1950s forms the background to the following question: Has anything important happened since then in psychological research to help us to a better understanding of how and why individuals think, feel, act, and react as they do in real life and how they develop over time? The studies serve as a background for some general propositions about the nature of the phenomena that concerns us in developmental research, for a summary description of the developments in psychological research over the last 40 years as I see them, and for some suggestions about future directions.

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