Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions

Abstract Objectives Endometriosis is a chronic disease which is diagnosed by surgical intervention combined with a histological work-up. Current international and national recommendations do not require the histological determination of the proliferation rate. The diagnostic and clinical importance of the mitotic rate in endometriotic lesions still remains to be elucidated. Methods In this retrospective study, the mitotic rates and clinical data of 542 patients with histologically diagnosed endometriosis were analyzed. The mean patient age was 33.5 ± 8.0 (17 – 72) years, and the mean reproductive lifespan was 21.2 ± 7.8 (4 – 41) years. Patients were divided into two groups and patientsʼ reproductive history and clinical endometriosis characteristics were compared between groups. The study group consisted of women with confirmed mitotic figures (n = 140, 25.83%) and the control group comprised women without proliferative activity according to their mitotic rates (n = 402, 74.27%). Results Women with endometriotic lesions and histologically confirmed mitotic figures were significantly more likely to have a higher endometriosis stage (p = 0.001), deep infiltrating endometriosis (p < 0.001), ovarian endometrioma (p = 0.012), and infertility (p = 0.049). A mitotic rate > 0 was seen significantly less often in cases with incidental findings of endometriosis (p = 0.031). The presence of symptoms and basic characteristics such as age, age at onset of menarche, reproductive lifespan and parity did not differ between the group with and the group without mitotic figures. Conclusion This study shows that a simple histological assessment of the mitotic rate offers additional diagnostic value for the detection of advanced stages of endometriosis. The possible role as a predictive marker for the recurrence of endometriosis or the development of endometriosis-associated cancer will require future study.

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The Clinical Importance of Subnormal Folate Levels in Epileptic Patients on Anticonvulsant Therapy

Scottish Medical Journal ◽

10.1177/003693308703200605 ◽

1987 ◽

Vol 32 (6) ◽

pp. 171-172 ◽

Cited By ~ 2

Author(s):

G.R. Nimmo ◽

M.J. Ryan ◽

N. Chalmers ◽

A.W. Patrick

Keyword(s):

Peripheral Neuropathy ◽

Clinical Importance ◽

Treated Group ◽

Anticonvulsant Therapy ◽

Serum Folate ◽

Control Group ◽

Asymptomatic Patients ◽

Epileptic Patients ◽

Normocytic Anaemia ◽

The Mean

A neurological history was obtained and examination performed on 62 outpatient epileptics on anticonvulsant therapy. Blood counts, folate and B12 assays were performed on all patients and on a control group of 59 adult non-epileptic neurological outpatients. None of the anticonvulsant treated group had clinical peripheral neuropathy; there was one patient with microcytic anaemia and one with normochromic, normocytic anaemia. In 5 of this group the mean corpuscular volume (MCV) was slightly raised but there was no significant overall difference from the control group. In 17 patients serum folate was subnormal and in 7 the red cell folate was subnormal and this was significantly different to the control group (P <0.001). Vitamin B12 levels were normal in all subjects. It is concluded that despite subnormal measured folate levels, there is no increased incidence of clinical peripheral neuropathy or of significant macrocytosis. In view of this, we recommend that folate replacement should not be given to non anaemic asymptomatic patients, with subnormal folate levels, on anticonvulsant therapy.

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The Platelet-Leukocyte Aggregates in Occlusive Arterial Disease and the Effect of Hydroxyethylrutosides

10.1055/s-0039-1680731 ◽

1977 ◽

Author(s):

M. Bielawiec ◽

B. Kiersnowska-Rogowska ◽

H. Łukjan

Keyword(s):

Healthy Subjects ◽

Arterial Disease ◽

Diagnostic Value ◽

Lower Limbs ◽

Control Group ◽

Arteriosclerosis Obliterans ◽

Occlusive Arterial Disease ◽

Nicotinic Acid Derivatives ◽

The Mean

The diagnostic value and the effect of the therapy on the number and kind of platelet-leukocyte aggregates in patients with arteriosclerosis obliterans of the lower limbs were investigated. The modified Silbergleit’s method was used. 8 types of aggregates were found. The mean number of aggregates in 20 healthy subjects was 8.2, in 52 patients suffering from obliterative arteriosclerosis of the lower limbs this number was significantly higher, that is 63.9. In healthy subjects most of the aggregates were type 1 to 4 whereas in the patients types 3 and 5 were most frequently found. 30 patients were treated for 3 weeks with hydroxyethylrutosides /HR/ - orally 600 mg three times daily or intravenously 1000 mg twice a day. A significant decrease of the number of platelet - leukocyte aggregates in the groups of patients receiving HR was found. The type of aggregates after HR was similar to that found in the control group. In 22 patients receiving nicotinic acid derivatives /orally 300 mg three times daily and intramuscularly 300 mg twice a day/ for 3 weeks no significant changes in the parameter investigated was observed. The method of differential counting of platelet-leukocyte aggregates may be of value in early diagnosis of occlusive arterial disease and in evaluation of their therapy.

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Diagnostic value of acustic radiation force impulse imaging in the assessment of salivary gland involvement in primary Sjögren’s sydrome

Medical Ultrasonography ◽

10.11152/mu-1397 ◽

2018 ◽

Vol 20 (3) ◽

pp. 313 ◽

Cited By ~ 8

Author(s):

Hale Turnaoglu ◽

Feride Kural Rahatli ◽

Melih Pamukcu ◽

Kemal Murat Haberal ◽

Nihal Uslu

Keyword(s):

Salivary Gland ◽

Radiation Force ◽

Diagnostic Value ◽

Acoustic Radiation Force Impulse ◽

Control Group ◽

Symptom Duration ◽

Parotid Glands ◽

Submandibular Glands ◽

The Mean ◽

Arfi Imaging

Aims: The aim of this study is to investigate the diagnostic value of Acoustic Radiation Force Impulse (ARFI) imaging in the assessment of salivary gland involvement in primary Sjögren’s syndrome (pSS).Material and methods: Twenty five patients with pSS and 25 healthy volunteers were included. First, echostructures and the thickness of the submandibular and parotid glands were evaluated by B-mode ultrasonography. Then, ARFI imaging with Virtual Touch Quantification® was performed. Ten independent shear wave velocity measurements were taken from each gland. Finally, the mean shear wavevelocity (SWV) values were calculated, and used for further analysis.Results: The mean SWV values of parotid and submandibular glands were significantly higher in the pSS patients than in the healthy control group (p<0.001). The cut-off of SWV values were calculated to be 1.98 m/s for submandibular glands, and 1.93 m/s for parotid glands. In pSS patients, the mean SWV values of parotid glands were higher than those of the submandibular glands (p<0.001) and no statistically significant relationships between symptom duration or the degree of xerostomia and mean SWV values of parotid and submandibularglands were found (all p>0.005).Conclusions: Our findings indicate that ARFI imaging may provide a non-invasive, simple and fast means of assessment of glandular impairment as an alternative test when other salivary gland tests are inconclusive or cannot be performed. ARFI may be a valuable adjunct for the clinical diagnosis of pSS.

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The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

Emergency Medicine International ◽

10.1155/2020/7925975 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7

Author(s):

Selman Yeniocak ◽

Fatma Saraç ◽

Mustafa Yazıcıoğlu ◽

Nadiye Karabulut ◽

Akın Ünal ◽

...

Keyword(s):

Emergency Department ◽

Abdominal Pain ◽

Acute Appendicitis ◽

Acute Abdominal Pain ◽

Diagnostic Value ◽

Cross Sectional Study ◽

Control Group ◽

Cross Sectional ◽

Ischemia Modified Albumin ◽

The Mean

Aim. The aim of this study was to evaluate the diagnostic value of serum ischemia-modified albumin (IMA) levels in patients presenting to the emergency department with acute abdominal pain and its use in differentiating acute surgical abdomen. Methods. This single-center prospective cross-sectional study included 334 adult patients who presented to the emergency department. These consisted of 194 patients (Group 1) with nontraumatic abdominal pain commencing in the preceding week, who were definitely diagnosed and either hospitalized in a specific department or planned for discharge, and a control group of 140 patients (Group 2). Results. The mean IMA value of the patients diagnosed with acute appendicitis was statistically significantly higher than that of the control group. The mean IMA value of the patients diagnosed with acute appendicitis, ovarian pathologies, and gastritis-peptic ulcer was statistically significantly higher than that of the nonspecific abdominal pain group. Conclusion. Serum IMA levels can be used as a diagnostic marker in patients with acute appendicitis. Furthermore, serum IMA levels in patients presenting to the emergency department with abdominal pain may be indicative of patients requiring surgery or of complicated cases, particularly in terms of acute appendicitis and ovarian pathologies.

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Serum Total and Free Prostate Specific Antigen Levels as Novel Biomarker in Patients with COVID-19

Iraq Medical Journal ◽

10.22317/imj.v5i3.1034 ◽

2021 ◽

Vol 5 (3) ◽

Keyword(s):

Retrospective Study ◽

Early Detection ◽

Prostate Specific Antigen ◽

Specific Antigen ◽

Diagnostic Value ◽

Control Group ◽

Tumor Biomarker ◽

Group Methods ◽

Group Control ◽

The Mean

Objectives: This study aimed to evaluate the diagnostic value of TPSA and FPSA for early detection of COVID-19 and compare it with a control group. Methods: This is a retrospective study of 146 patients from the Respiratory Clinic in Sebha city, 73 of whom have COVID-19 PCR-confirmed and 73 who do not have COVID-19 (group control). Results: The mean and standard division age in the PCR-confirmed COVID-19 group was 61.51±16.40. In the PCR-confirmed COVID-19 group, the mean and standard division serum biomarker level for TPSA was 0.51±.26 ng/ml, and 0.57± 0.32 for FPSA. Conclusion: For the biomarkers TPSA and FPSA, there were no significant differences between the control and PCR-confirmed COVID-19 groups. These findings suggest that the tumor biomarker may be ineffective in detecting COVID-19.

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Study on Palmar Dermatoglyphics and their Association with β Thalassemia Major Patients among Bangladeshi Population

Mediscope ◽

10.3329/mediscope.v8i2.55316 ◽

2021 ◽

Vol 8 (2) ◽

pp. 94-102

Author(s):

Afroj Zahan ◽

Humaira Naushaba ◽

Uttam Kumar Paul ◽

AHM Mazharul Islam ◽

Sharna Moin ◽

...

Keyword(s):

Thalassemia Major ◽

Diagnostic Value ◽

Control Group ◽

Case Group ◽

Healthy Individuals ◽

Ridge Count ◽

Cross Sectional ◽

Medical College ◽

The Mean ◽

Bangladeshi Population

Objectives: To observe the palmar dermatoglyphic patterns of β thalassemia major patients. Methods: This cross-sectional type of analytical study was performed in the Department of Anatomy, Sir Sallimullah Medical College, Dhaka between the periods of January 2016 to December 2016. 55 β thalassemia major patients aged between (5-35) years were considered as case group and 55 healthy individuals of the same age & sex were considered as control group in this study. The palmar dermatoglyphic patterns and Total Finger Ridge count (TFRC) on the distal phalanges of the β thalassemia major patients were observed and compared with healthy individuals. Results: The palmar dermatoglyphic patterns were significantly different between the two groups (p > 0.05). The mean (±SD) of Total Finger Ridge count (TFRC) were higher in β thalassemia major patients in comparison to the healthy individuals. Conclusion: This study concludes that, palmar dermatoglyphic has a diagnostic value for β thalassemia major patients. Mediscope 2021;8(2): 94-102

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The Diagnostic Value of Pulsar Perimetry, Optical Coherence Tomography, and Optical Coherence Tomography Angiography in Pre-Perimetric and Perimetric Glaucoma

Journal of Clinical Medicine ◽

10.3390/jcm10245825 ◽

2021 ◽

Vol 10 (24) ◽

pp. 5825

Author(s):

Hung-Chih Chen ◽

Michael Chia-Yen Chou ◽

Ming-Tsung Lee ◽

Chia-Yi Lee ◽

Che-Ning Yang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Ganglion Cell ◽

Optical Coherence Tomography Angiography ◽

Diagnostic Value ◽

Vessel Density ◽

Control Group ◽

Ganglion Cell Complex ◽

Optical Coherence ◽

The Mean ◽

Sensitive Parameters

The purpose of this article is to investigate the diagnostic value of Pulsar perimetry (PP), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) in pre-perimetric glaucoma (PPG) and perimetric glaucoma (PG). This retrospective cross-sectional study included 202 eyes (145 eyes in the control group, 40 eyes in the PPG group, and 17 eyes in the PG group) from 105 subjects. The results were analyzed by paired t-tests and Wilcoxon signed-rank test. The area under the curve (AUC), sensitivity, and specificity were used to evaluate the diagnostic accuracy. Pearson correlation was used to investigate the relationships of each parameter. The most sensitive parameters for differentiating the control group from the PPG group by using Pulsar, OCT, and OCTA were square loss variance of PP (AUC = 0.673, p < 0.001), superior ganglion cell complex thickness (AUC = 0.860, p < 0.001), and superior-hemi retina thickness (AUC = 0.817, p < 0.001). In the PG group, the most sensitive parameters were mean defect of PP (AUC = 0.885, p < 0.001), whole image of ganglion cell complex thickness (AUC = 0.847, p < 0.001), and perifoveal retina thickness (AUC = 0.833, p < 0.001). The mean defect of PP was significantly correlated with vascular parameters (radial peripapillary capillary (RPC), p = 0.008; vessel density of macular superficial vascular complex (VDms), p = 0.001; vessel density of macular deep vascular complex (VDmd), p = 0.002). In conclusion, structural measurements using OCT were more sensitive than vascular measurements of OCTA and functional measurements of PP for PPG, while PP was more sensitive than the structural and vascular measurements for PG. The mean defect of PP was also shown to be highly correlated with the reduction of vessel density.

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Vitamin D Treatment in Patients with Hashimoto’s Thyroiditis may Decrease the Development of Hypothyroidism

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000269 ◽

2016 ◽

Vol 86 (1-2) ◽

pp. 9-17 ◽

Cited By ~ 3

Author(s):

Bekir Ucan ◽

Mustafa Sahin ◽

Muyesser Sayki Arslan ◽

Nujen Colak Bozkurt ◽

Muhammed Kizilgul ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Hashimoto’S Thyroiditis ◽

Healthy Control Group ◽

Hashimoto's Thyroiditis ◽

Control Group ◽

Endocrine Society ◽

Thyroid Autoantibody ◽

Healthy Control ◽

The Mean

Abstract.The relationship between Hashimoto’s thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto’s thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto’s thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL. Vitamin D deficient patients were given 50.000 units of 25(OH)D3 weekly for eight weeks in accordance with the Endocrine Society guidelines. All evaluations were repeated after 2 months of treatment. Patients with Hashimoto’s thyroiditis had significantly lower vitamin D concentrations compared with the controls (9.37±0.69 ng/mL vs 11.95±1.01 ng/mL, p < 0.05, respectively). Thyroid autoantibodies were significantly decreased by vitamin D replacement treatment in patients with euthyroid Hashimoto’s thyroiditis. Also, HDL cholesterol concentrations improved in the euthyroid Hashimoto group after treatment. The mean free thyroxine (fT4) concentrations were 0.89±0.02 ng/dL in patients with Hashimoto’s thyroiditis and 1.07±0.03 ng/dL in the healthy control group (p < 0.001). The mean thyroid volumes were 7.71±0.44 mL in patients with Hashimoto’s thyroiditis and 5.46±0.63 mL in the healthy control group (p < 0.01). Vitamin D deficiency is frequent in Hashimoto’s thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. Vitamin D measurement and replacement may be critical in these patients.

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Mental Health Among Adolescents from Returned Portuguese Immigrant Families

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000015 ◽

2010 ◽

Vol 69 (3) ◽

pp. 131-139 ◽

Cited By ~ 5

Author(s):

Félix Neto

Keyword(s):

Mental Health ◽

Health Outcomes ◽

Mental Health Problems ◽

Immigrant Families ◽

Health Problems ◽

Mental Health Outcomes ◽

Control Group ◽

Older Adolescents ◽

The Mean ◽

Portuguese Adolescents

This study investigated mental health problems and their predictors among adolescents from returned immigrant families. The sample consisted of 360 returned adolescents (mean age = 16.8 years; SD = 1.9). The mean duration of a sojourn in Portugal for the sample was 8.2 years (SD = 4.5). A control group of 217 Portuguese youths were also included in the study. Adolescents from immigrant families reported mental health levels similar to those of Portuguese adolescents who have never migrated. Girls showed more mental health problems than boys. Younger adolescents showed fewer mental health problems than older adolescents. Adaptation variables contributed to mental health outcomes even after acculturation variables were accounted for. Implications of the study for counselors are discussed.

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Rorschach Characteristics in Adolescents with Systemic Lupus Erythematosus

Rorschachiana Journal of the International Society for the Rorschach ◽

10.1027/1192-5604.28.1.100 ◽

2006 ◽

Vol 28 (1) ◽

pp. 100-118 ◽

Cited By ~ 1

Author(s):

J. Santoantonio ◽

L. Yazigi ◽

E. I. Sato

Keyword(s):

Lupus Erythematosus ◽

Case Control Study ◽

Activity Index ◽

Disease Activity Index ◽

Female Adolescents ◽

Control Group ◽

Intelligence Scale ◽

The Mean ◽

Experimental Group ◽

Control Study

The purpose of this study was to investigate the personality characteristics in adolescents with SLE. The research design is a case-control study by means of the Rorschach Method and the Wechsler Intelligence Scale. Study group: 30 female adolescents with lupus, 12–17 years of age. The SLE Disease Activity Index was administered during the period of psychological evaluation. Control group: 32 nonpatient adolescents were matched for age, sex, and socioeconomic level. In the Wechsler Intelligence Scale the mean IQ of the experimental group was significantly lower than that of the control group (77 and 98, respectively, p < .001). In the Rorschach, the lupus patients showed greater difficulty in interpersonal interactions, although they displayed the resources to process affect and to cope with stressful situations. A positive moderate correlation (p = .069) between the activity index of the disease and the affect constriction proportion of the Rorschach was observed: the higher the SLEDAI score, the lower the capacity to process affect. There is a negative correlation between the activity index of the disease and the IQ (p = .001): with a higher activity index of the disease, less intellectual resources are available.

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