Recent Advances in The Smiles Rearrangement: New Opportunities for Arylation

Synthesis ◽  
2021 ◽  
Author(s):  
David Whalley ◽  
Michael Greaney
Keyword(s):  
Short Review ◽  
Smiles Rearrangement ◽  
Heterocycle Synthesis ◽  
Recent Advances ◽  
New Directions

The Smiles rearrangement has undergone a renaissance in recent years providing new avenues for non-canonical arylation techniques in both the radical and polar regimes. This Short Review will discuss recent applications of the reaction (from 2017 onwards), including its relevance to areas such as heterocycle synthesis, functionalisation of alkenes and alkynes as well as glimpses at new directions for the field.

A Short Review of Recent Advances in Direct CO2 Hydrogenation to Alcohols

2021 ◽  
Author(s):  
Shunan Zhang ◽  
Zhaoxuan Wu ◽  
Xiufang Liu ◽  
Kaimin Hua ◽  
Zilong Shao ◽  
...  
Keyword(s):  
Short Review ◽  
Co2 Hydrogenation ◽  
Recent Advances

scholarly journals Recent Advances in Non‐nucleophilic Mg Electrolytes

2021 ◽  
Vol 7 ◽  
Author(s):  
Qijie Wu ◽  
Kewei Shu ◽  
Lili Sun ◽  
Haihua Wang
Keyword(s):  
High Performance ◽  
Early Stage ◽  
Oxidation Stability ◽  
Short Review ◽  
High Reactivity ◽  
Inherent Safety ◽  
Practical Application ◽  
Safety Issues ◽  
Ion Structure ◽  
Recent Advances

High-performance electrolyte is still a roadblock for the development of rechargeable magnesium (Mg) batteries. Grignard-type electrolytes were once the only choice in the early stage of rechargeable Mg batteries research. However, due to their nucleophilic nature and high reactivity, Grignard-type electrolytes have inherent safety issues and low oxidation stability, which restrict the development of rechargeable Mg batteries in terms of practical application. Recently, emerging novel Mg battery systems such as Mg-S, Mg-O2/air batteries also require non‐nucleophilic electrolytes with high oxidation stability. This short review summarizes recent advances in non‐nucleophilic Mg electrolytes and aims to provide insights into electrochemical properties and active Mg ion structure of such electrolytes.

Five-Membered Hetarene N-Oxides: Recent Advances in Synthesis and Reactivity

Synthesis ◽  
2021 ◽  
Author(s):  
Leonid Fershtat ◽  
Fedor Teslenko
Keyword(s):  
Transition Metal ◽  
Medicinal Chemistry ◽  
Materials Science ◽  
State Of The Art ◽  
Short Review ◽  
Advanced Materials ◽  
Metal Free ◽  
Recent Advances ◽  
Application Potential ◽  
Metal Catalyzed

Five-membered heterocyclic N-oxides attracted special attention due to their strong application potential in medicinal chemistry and advanced materials science. In this regard, novel methods for their synthesis and functionalization are constantly required. In this short review, recent state-of-the-art achievements in the chemistry of isoxazoline N-oxides, 1,2,3-triazole 1-oxides and 1,2,5-oxadiazole 2-oxides are briefly summarized. Main routes to transition-metal-catalyzed and metal-free functionalization protocols along with mechanistic considerations are outlined. Transformation patterns of the hetarene N-oxide rings as precursors to other nitrogen heterocyclic systems are also presented.

Recent Advances of 1,3,5-Triazinanes in Aminomethylation and Cycloaddition Reactions

Synthesis ◽  
2020 ◽  
Vol 52 (17) ◽  
pp. 2469-2482
Author(s):  
Jia-Rong Chen ◽  
Dong Liang ◽  
Wen-Jing Xiao
Keyword(s):  
Reaction Mechanisms ◽  
Short Review ◽  
Cycloaddition Reactions ◽  
Recent Advances ◽  
Nitrogen Containing Compounds

1,3,5-Trisubstituted 1,3,5-triazinanes (hexahydro-1,3,5-triazines), as stable and readily available surrogates for formaldimines, have found extensive applications for the construction of various nitrogen-containing compounds. The formaldimines, formed in situ from this reagent class, can participate in various aminomethylation and cycloaddition­ reactions. This short review presents recent advances in this field with emphasis on the conceptual ideas behind the developed methodologies and the reaction mechanisms.1 Introduction2 Aminomethylations with 1,3,5-Triazinanes3 Cycloadditions with 1,3,5-Triazinanes3.1 Use of 1,3,5-Triazinanes as Two-Atom Synthons3.2 Use of 1,3,5-Triazinanes as Three-Atom Synthons3.3 Use of 1,3,5-Triazinanes as Four-Atom Synthons3.4 Use of 1,3,5-Triazinanes as Six-Atom Synthons4 Conclusions

scholarly journals Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles

Synthesis ◽  
2019 ◽  
Vol 51 (05) ◽  
pp. 1100-1114 ◽  
Author(s):  
Emilia Groso ◽  
Corinna Schindler
Keyword(s):  
Olefin Metathesis ◽  
Nitrogen Heterocycles ◽  
Short Review ◽  
Catalyst Design ◽  
Carbene Ligands ◽  
Ring Closing Metathesis ◽  
Recent Advances ◽  
Metathesis Reactions

This short review summarizes recent advances relating to the application of ring-closing olefin-olefin and carbonyl-olefin metathesis reactions towards the synthesis of unsaturated five- and six-membered nitrogen heterocycles. These developments include catalyst modifications and reaction designs that will enable access to more complex nitrogen heterocycles.1 Introduction2 Expansion of Ring-Closing Metathesis Methods3 Evaluation of Catalyst Design4 Indenylidene Catalysts5 Unsymmetrical N-Heterocyclic Carbene Ligands6 Carbonyl-Olefin Metathesis7 Conclusions

scholarly journals X-ray Cluster Large Scale Structure and Cosmology

2005 ◽  
Vol 216 ◽  
pp. 373-380
Author(s):  
Marguerite Pierre
Keyword(s):  
Dark Energy ◽  
Galaxy Clusters ◽  
Large Scale ◽  
Scaling Law ◽  
Large Scale Structure ◽  
Short Review ◽  
Scale Structure ◽  
X Ray ◽  
Recent Advances

We outline the main arguments in favor of cosmological X-ray surveys of galaxy clusters. We summarize recent advances in our understanding of cluster physics. After a short review of past surveys, we present the scientific motivations of the XMM Large Scale Structure survey. We further illustrate how such a survey can help constrain the nature of the dark energy as well as cluster scaling law evolution, i.e. non-gravitational physics.

Recent advances in hydrogen generation process via hydrolysis of Mg-based materials: A short review

2020 ◽  
Vol 816 ◽  
pp. 152634 ◽  
Author(s):  
XiuBo Xie ◽  
Cui Ni ◽  
Baolei Wang ◽  
Yuping Zhang ◽  
Xiangjin Zhao ◽  
...  
Keyword(s):  
Hydrogen Generation ◽  
Short Review ◽  
Generation Process ◽  
Recent Advances ◽  
Hydrolysis Of

Synthesis of Fluorinated and Trifluoromethyl-Substituted Alkenes through the Modified Julia Olefination: An Update

Synthesis ◽  
2015 ◽  
Vol 47 (11) ◽  
pp. 1534-1546 ◽  
Author(s):  
Emmanuel Pfund ◽  
Thierry Lequeux ◽  
David Gueyrard
Keyword(s):  
Large Range ◽  
Short Review ◽  
The Novel ◽  
Smiles Rearrangement ◽  
Julia Olefination

The modified Julia olefination is now a powerful tool for the synthesis of a large range of functionalized alkenes. This short review covers the last five years and provides an overview of the synthesis of mono-, difluoro-, and trifluoromethyl-substituted alkenes via the modified Julia olefination focusing on the novel scope of this reaction.1 Introduction2 Monofluoroalkenes2.1 Disubstituted α- and β-Monofluoroalkenes2.2 Bis(trifluoromethyl)phenyl Sulfones2.3 Conjugated Monofluoroalkenes2.4 Intramolecular Julia Olefination2.5 Smiles Rearrangement from Fluorinated Keto Sulfones2.6 Fluoroallylamines2.7 Fluorinated exo-Glycals2.8 Monofluoroalkenes with an α-Stereocenter at the Allylic Position3 1,1-Difluoroalkenes4 Trifluoromethyl-Substituted Alkenes5 Conclusion

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