A single quantitative trait locus on mouse chromosome 11 modifies in vitro hepatocyte susceptibility to TGF-β and in vivo fibrogenesis following CCl4 injections

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
R Liebe ◽  
R Hall ◽  
S Dooley ◽  
F Lammert
Keyword(s):  
Quantitative Trait Locus ◽  
Mouse Chromosome ◽  
Quantitative Trait ◽  
Chromosome 11 ◽  
Single Quantitative Trait Locus ◽  
Trait Locus ◽  
Mouse Chromosome 11

scholarly journals IDENTIFICATION OF A MAJOR QUANTITATIVE TRAIT LOCUS CONFERRING RICE BLAST RESISTANCE USING RECOMBINANT INBRED LINES

2013 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
Sobrizal Sobrizal ◽  
Masdiar Bustamam ◽  
Carkum Carkum ◽  
Ahmad Warsun ◽  
Soeranto Human ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Recombinant Inbred ◽  
Blast Resistance ◽  
Blast Disease ◽  
Chromosome 11 ◽  
Resistant Gene ◽  
Trait Locus ◽  
Ri Lines ◽  
Major Qtl

Blast disease caused by Pyricularia oryzae is one of the limiting factors for rice production world wide. The use of resistant varieties for managing blast disease is considered as the most eco-friendly approaches. However, their resistances may be broken down within a few years due to the appearance of new virulent blast races in the field. The objective of the present study was to identify the quantitative trait locus (QTL) conferring resistance to blast disease using 126 recombinant inbred (RI) lines originated from a crossing of a durably resistant upland rice genotype (Laka) and a highly susceptible rice accession cultivar (Kencana Bali). The RI population was developed through a single seed descent method from 1997 to 2004. Resistance of the RI lines was evaluated for blast in an endemic area of Sukabumi, West Java, in 2005. Disease intensity of the blast was examined following the standard evaluation system developed by the International Rice Research Institute (IRRI). At the same year the RI lines were analyzed with 134 DNA markers. Results of the study showed that one major QTL was found to be associated with blast resistance, and this QTL was located near RM2136 marker on the long arm of chromosome 11. This QTL explained 87% of the phenotypic variation with 37% additive effect. The map position of this QTL differed from that of a partial resistant gene, Pi34, identified previously on chromosome 11 in the Japanese durably resistant variety, Chubu 32. The QTL, however, was almost at the same position as that of the multiple allele-resistant gene, Pik. Therefore, an allelic test should be conducted to clarify the allelic relationship between QTL identified in this study and the Pik. The RI lines are the permanent segregating population that could be very useful for analysing phenotypic variations of important agronomic traits possibly owned by the RI lines. The major QTL identified in this study could be used as a genetic resource in improvement of rice varieties for blast resistance in Indonesia

scholarly journals Quantitative trait locus mapping for common scab resistance in a tetraploid potato full-sib population

Plant Disease ◽  
2021 ◽  
Author(s):  
Guilherme Da Silva Pereira ◽  
Marcelo Mollinari ◽  
Xinshun Qu ◽  
Christian Thill ◽  
Zhao-Bang Zeng ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Common Scab ◽  
Negative Impact ◽  
Potato Industry ◽  
Scab Resistance ◽  
Bacterial Disease ◽  
Streptomyces Spp ◽  
Single Quantitative Trait Locus ◽  
Trait Locus

Despite the negative impact of common scab (Streptomyces spp.) on the potato industry, little is known about the genetic architecture of resistance to this bacterial disease in the crop. We evaluated a mapping population (~150 full-sibs) derived from a cross between two tetraploid potatoes (‘Atlantic’ × B1829-5) in three environments (MN11, PA11, ME12) under natural common scab pressure. Three measures to common scab reaction, namely percentage of scabby tubers, and disease area and lesion indices, were found to be highly correlated (>0.76). Due to the large environmental effect, heritability values were zero for all three traits in MN11, but moderate to high in PA11 and ME12 (0.44~0.79). We identified a single quantitative trait locus (QTL) for lesion index in PA11, ME12 and joint analyses on linkage group 3, explaining 22~30% of the total variation. The identification of QTL haplotypes and candidate genes contributing to disease resistance can support genomics-assisted breeding approaches in the crop.

scholarly journals A Novel Quantitative Trait Locus on Mouse Chromosome 18, “era1,” Modifies the Entrainment of Circadian Rhythms

SLEEP ◽  
2007 ◽  
Vol 30 (10) ◽  
pp. 1255-1263 ◽  
Author(s):  
Jonathan P. Wisor ◽  
Martin Striz ◽  
Jason DeVoss ◽  
Greer M. Murphy ◽  
Dale M. Edgar ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Circadian Rhythms ◽  
Mouse Chromosome ◽  
Quantitative Trait ◽  
Chromosome 18 ◽  
Trait Locus

Influence of a Quantitative Trait Locus on Mouse Chromosome 19 to the Light-Adapted Electroretinogram

2008 ◽  
Vol 49 (9) ◽  
pp. 4058 ◽  
Author(s):  
Alison L. Reynolds ◽  
Michael Danciger ◽  
G. Jane Farrar ◽  
Peter Humphries ◽  
Paul F. Kenna
Keyword(s):  
Quantitative Trait Locus ◽  
Mouse Chromosome ◽  
Quantitative Trait ◽  
Chromosome 19 ◽  
Trait Locus

scholarly journals Identification of Soat1 as a Quantitative Trait Locus Gene on Mouse Chromosome 1 Contributing to Hyperlipidemia

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e25344 ◽  
Author(s):  
Zongji Lu ◽  
Zuobiao Yuan ◽  
Toru Miyoshi ◽  
Qian Wang ◽  
Zhiguang Su ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Mouse Chromosome ◽  
Quantitative Trait ◽  
Chromosome 1 ◽  
Trait Locus ◽  
Mouse Chromosome 1

Quantitative trait locus mapping of genes regulating pulmonary PKC activity and PKC-α content

2000 ◽  
Vol 279 (2) ◽  
pp. L326-L332 ◽  
Author(s):  
Lori D. Dwyer-Nield ◽  
Beverly Paigen ◽  
Stephanie E. Porter ◽  
Alvin M. Malkinson
Keyword(s):  
Quantitative Trait Locus ◽  
Likelihood Ratio ◽  
Quantitative Trait ◽  
Single Gene ◽  
Inbred Mouse ◽  
Likelihood Ratio Statistic ◽  
Mouse Strains ◽  
Chromosome 11 ◽  
Major Locus ◽  
Trait Locus

Strain A/J mice, which are predisposed to experimentally induced asthma and adenocarcinoma, have the lowest pulmonary protein kinase (PK) C activity and content among 22 inbred mouse strains. PKC in neonatal A/J mice is similar to that in other strains, so this difference reflects strain-dependent postnatal regulation. PKC activity is 60% higher in C57BL/6J (B6) than in A/J lungs, and the protein and mRNA concentrations of PKC-α, the major pulmonary PKC isozyme, are two- to threefold higher in B6 mice. These differences result from more than a single gene as assessed in F1, F2, and backcross progeny of B6 and A/J parents. Quantitative trait locus (QTL) analysis of 23 A×B and B×A recombinant inbred strains derived from B6 and A/J progenitors indicates a major locus regulating lung PKC-α content that maps near the Pkcα structural gene on chromosome 11 ( D11MIT333; likelihood ratio statistic = 12.5) and a major locus controlling PKC activity that maps on chromosome 3 ( D3MIT19; likelihood ratio statistic = 15.4). The chromosome 11 QTL responsible for low PKC-α content falls within QTLs for susceptibilities to lung tumorigenesis and ozone-induced toxicity.

A major quantitative trait locus on mouse chromosome 3 is involved in disease susceptibility in different colitis models

2005 ◽  
Vol 128 (1) ◽  
pp. 74-85 ◽  
Author(s):  
Michelle E.A. Borm ◽  
Jianping He ◽  
Brian Kelsall ◽  
A. Salvador Peña ◽  
Warren Strober ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Mouse Chromosome ◽  
Quantitative Trait ◽  
Major Quantitative Trait Locus ◽  
Disease Susceptibility ◽  
Chromosome 3 ◽  
Trait Locus
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