Dissolution and Pharmacokinetic Properties of Alkaloids and Flavonoids in a Xiexin Multiple-unit Drug Delivery System

Drug Research ◽  
2013 ◽  
Vol 63 (10) ◽  
pp. 501-509 ◽  
Author(s):  
Y. Xie ◽  
Y. Hu ◽  
M. Shen ◽  
Y. Ma ◽  
J. Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pharmacokinetic Properties ◽  
Multiple Unit

The in vivo transformation and pharmacokinetic properties of a liquid crystalline drug delivery system

2017 ◽  
Vol 532 (1) ◽  
pp. 345-351 ◽  
Author(s):  
Andrew Otte ◽  
Yahira M. Báez-Santos ◽  
Ellina A. Mun ◽  
Bong-Kwan Soh ◽  
Young-nam Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Pharmacokinetic Properties

Suitable Polymers in Floating Gastro-Retentive Drug Delivery

2020 ◽  
pp. 371-382
Author(s):  
Kaustubh Gavali ◽  
Preeti Karade
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Floating Drug Delivery ◽  
Effect Of Food ◽  
Multiple Unit ◽  
Novel Drug ◽  
Absorption Window ◽  
Gastro Retentive

Gastro-retentive drug delivery is novel drug delivery system which is emerged for controlled and targeted delivery of drug especially when target site lies in or near the stomach. The drug with absorption window in stomach, locally acting drug in stomach, etc. are the best suitable candidate for this drug delivery system. It can be formulated in various types like floating, expandable & unfoldable, Raft forming, swelling system Bio adhesive, High density system etc. The gastro-retentive form can be used in various dosage forms like tablet, capsule, microsphere, granules, powders, pills and laminated films according to the need. It can be also formulated as single unit and multiple unit dosage form but sometime this gastro-retention is unpredictable due to effect of pH, gastric mobility, effect of food etc. This review mainly focuses on the floating drug delivery its types, polymer used in floating drug delivery and application.

PEGylation and Cell-Penetrating Peptides: Glimpse into the Past and Prospects in the Future

2020 ◽  
Vol 20 (5) ◽  
pp. 337-348 ◽  
Author(s):  
Sumit Kumar ◽  
Devender Singh ◽  
Pooja Kumari ◽  
Rajender Singh Malik ◽  
Poonam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Target ◽  
Pharmacokinetic Profile ◽  
Cell Penetrating Peptides ◽  
Physiochemical Properties ◽  
Drug Molecules ◽  
Pharmacokinetic Properties ◽  
Cell Penetrating

Several drug molecules have shown low bioavailability and pharmacokinetic profile due to metabolism by enzymes, excretion by the renal system, or due to other physiochemical properties of drug molecules. These problems have resulted in the loss of efficacy and the gain of side effects associated with drug molecules. PEGylation is one of the strategies to overcome these pharmacokinetic issues and has been successful in the clinic. Cell-penetrating Peptides (CPPs) help to deliver molecules across biological membranes and could be used to deliver cargo selectively to the intracellular site or to the drug target. Hence CPPs could be used to improve the efficacy and selectivity of the drug. However, due to the peptidic nature of CPPs, they have a low pharmacokinetic profile. Using PEGylation and CPPs together as a component of a drug delivery system, the and efficacy of drug molecules could be improved. The other important pharmacokinetic properties such as short half-life, solubility, stability, absorption, metabolism, and elimination could be also improved. Here in this review, we summarized PEGylated CPPs or PEGylation based formulations for CPPs used in a drug delivery system for several biomedical applications until August 2019.

scholarly journals A Brief Review on Floating Drug Delivery System

2021 ◽  
Vol 11 (4) ◽  
pp. 93-95
Author(s):  
Divya Arora ◽  
Lalit Kumar ◽  
Ashish Joshi ◽  
Abhishek Chaudhary ◽  
Pooja Devi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Intervention ◽  
Therapeutic Benefits ◽  
Medication Delivery ◽  
Floating Drug Delivery ◽  
Long Time ◽  
Multiple Unit ◽  
Floating Drug Delivery System

Floating drug delivery systems (FDDS) was most convenient and widely used drug delivery for systemic intervention, oral administration. The main purpose of developing the FDDS is to enhance therapeutic benefits such as ease of dosing administration, patient compliance, and formulation versatility. In pharmaceuticals industries we are approaches  to  design single-unit  and  multiple-unit  floating  systems,  and  classification  and  formulation  of FDDS aspects  are  covered  in detail.  This review summarizes the tablet, Floating Drug Delivery System, Type, Mechanism, and also the Advantages & Disadvantages. This sort of medication delivery method is beneficial because it has enough buoyancy to float above gastric contents and stay buoyant in the stomach for a long time. Keywords:- FDDS, Floating Drug Delivery System, Therapeutic, Design, Buoyant, Gastric

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