Metabolomic strategies in dereplication for targeted cultivation and isolation of new bioactive secondary metabolites from fungal endophytes and marine microbial symbionts

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Cheng ◽  
U Abdelmohsen ◽  
T Grkovic ◽  
RJ Quinn ◽  
U Hentschel ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Fungal Endophytes ◽  
Bioactive Secondary Metabolites ◽  
Microbial Symbionts

scholarly journals Cytotoxic Compounds Derived from Marine Algicolous and Spongicolous Endophytic Fungi: A Review

2021 ◽  
Vol 20 (2) ◽  
pp. 247-265
Author(s):  
Nadia Tasnim Ahmed ◽  
Sadia Noor ◽  
Md Mustafizur Rahman ◽  
Md Abdul Mazid
Keyword(s):  
Secondary Metabolites ◽  
Endophytic Fungi ◽  
Fungal Endophytes ◽  
Bioactive Secondary Metabolites ◽  
Cytotoxic Compounds ◽  
Cell Components ◽  
Long Time ◽  
Number Of Publications ◽  
Functionally Diverse ◽  
Antimicrobial Metabolites

Endophytes have gained particular interest in the search of potential pharmaceutical candidates for a long time due to their diversity, species richness and bioprospecting nature. They generally produce the essential metabolites for their expansion inside the plant which is involved in various biotransformation processes of utilizing host nutrients and cell components to continue microbial growth, sustenance, and reproduction. In above processes, they produce a huge amount of both structurally and functionally diverse secondary metabolites for maintaining an effective symbiosis with hosts. These compounds are proven to have significant bioactive properties like antibacterial, antifungal, antiviral, anti-inflammatory, antioxidants, antitumor activities. Despite the proven significance, a little is exploited so far about endophytes. Particularly marine fungal endophytes which are the centre of attention in this review have gained much less importance. Due to unique environmental feature, fungal endophytes derived from marine environment offer vast diversity in different bioactive secondary metabolites. This review has focused on algicolous endophytes and bioactive secondary metabolites discovered during the last two decades. Particular importance has been given to cytotoxic and antimicrobial metabolites. Due to intensive studies during last several years, an extensive number of publications are now available on cytotoxic compounds derived from endophytic fungi of marine algicolous and spongicolous origin that have been summarized in this review. Dhaka Univ. J. Pharm. Sci. 20(2): 247-265, 2021 (December)

scholarly journals Bioactive Secondary Metabolites Produced by the Fungal Endophytes of Conifers

2015 ◽  
Vol 10 (10) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Andrea A. Stierle ◽  
Donald B. Stierle
Keyword(s):  
Secondary Metabolites ◽  
Endophytic Fungi ◽  
Active Component ◽  
Plant Pathogens ◽  
Insect Pests ◽  
Human Cancer ◽  
Fungal Endophytes ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Bioactive Secondary Metabolites

This is a review of bioactive secondary metabolites isolated from conifer-associated endophytic fungi from 1990-2014. This includes compounds with antimicrobial, anti-inflammatory, anti-proliferative and cytotoxic activity towards human cancer cell lines, and activity against either plant pathogens or plant insect pests. Compounds that were originally reported without associated activity were included if other studies ascribed activity to these compounds. Compounds were not included if they were exclusively phytotoxic or if they were isolated from active extracts but were not determined to be the active component of that extract.

Bioactive Secondary Metabolites from Geosmithia langdonii

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
LG Malak ◽  
DW Bishay ◽  
AM Abdel-baky ◽  
AM Moharram ◽  
SJ Cutler ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Secondary Metabolites

Screening bioactive secondary metabolites from Costa Rican enviromental microbial communities

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
JJ Araya ◽  
M Chavarría ◽  
A Pinto-Tomás ◽  
C Murillo ◽  
L Uribe ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Microbial Communities ◽  
Costa Rican ◽  
Bioactive Secondary Metabolites
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