Cutaneous paraneoplastic syndrome in a cat with thymoma

2013 ◽  
Vol 41 (04) ◽  
pp. 255-259 ◽  
Author(s):  
J. Karaś-Tęcza ◽  
R. Lechowski ◽  
A. Rodo ◽  
I. Dolka ◽  
O. Gójska-Zygner
Keyword(s):  
Paraneoplastic Syndrome ◽  
Histopathological Examination ◽  
Skin Condition ◽  
Radiographic Examination ◽  
Post Mortem ◽  
Ventral Part ◽  
Soft Tissue Density ◽  
Skin Changes ◽  
Exfoliative Dermatitis ◽  
Costs Of Treatment

SummaryFeline cutaneous paraneoplastic syndrome is a rare disorder associated mainly with pancreatic carcinoma and thymoma. In this report the authors describe the case of a 12-year-old cat with paraneoplastic exfoliative dermatitis associated with thymoma. Lateral radiographic examination of the chest showed a small subtle soft tissue density in the ventral part of the first and second intercostal space, which together with skin changes suggested thymoma. Because of pain associated with the skin condition, costs of treatment and the risk associated with surgical treatment, the owner chose euthanasia of the cat. Post-mortem examination revealed a tumour which was diagnosed as thymoma by histopathological examination.

scholarly journals Scopolamine fatal outcome in an inmate after buscopan® smoking

2021 ◽  
Author(s):  
Sabina Strano-Rossi ◽  
Serena Mestria ◽  
Giorgio Bolino ◽  
Matteo Polacco ◽  
Simone Grassi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Drug Abuse ◽  
Muscarinic Receptors ◽  
Histopathological Examination ◽  
Fatal Outcome ◽  
Post Mortem ◽  
Butyl Bromide ◽  
Cannabis Abuse ◽  
Toxic Concentration ◽  
History Of

AbstractScopolamine is an alkaloid which acts as competitive antagonists to acetylcholine at central and peripheral muscarinic receptors. We report the case of a 41-year-old male convict with a 27-year history of cannabis abuse who suddenly died in the bed of his cell after having smoked buscopan® tablets. Since both abuse of substances and recent physical assaults had been reported, we opted for a comprehensive approach (post-mortem computed tomography CT (PMCT), full forensic autopsy, and toxicology testing) to determine which was the cause of the death. Virtopsy found significant cerebral edema and lungs edema that were confirmed at the autopsy and at the histopathological examination. Scopolamine was detected in peripheral blood at the toxic concentration of 14 ng/mL in blood and at 263 ng/mL in urine, and scopolamine butyl bromide at 17 ng/mL in blood and 90 ng/mL in urine. Quetiapine, mirtazapine, lorazepam, diazepam, and metabolites and valproate were also detected (at therapeutic concentrations). Inmates, especially when they have a history of drug abuse, are at risk to use any substance they can find for recreational purposes. In prisons, active surveillance on the management and assumption of prescribed drugs could avoid fatal acute intoxication.

scholarly journals POEMS-syndrome: diagnostic difficulties

2020 ◽  
Vol 92 (7) ◽  
pp. 104-108
Author(s):  
P. A. Lebedev ◽  
E. V. Paranina ◽  
V. A. Rossiyev ◽  
E. Y. Fedorova ◽  
A. S. Nikolaeva
Keyword(s):  
Paraneoplastic Syndrome ◽  
Early Onset ◽  
Clinical Case ◽  
Specific Treatment ◽  
Poems Syndrome ◽  
Skin Changes ◽  
Monoclonal Protein ◽  
Diagnostic Difficulties

POEMS syndrome is a rare paraneoplastic syndrome whose name is an acronym formed from the initial letters of the names of the symptoms originally used to determine it: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes. Due to the rarity of the disease and the small number of cases described in the literature, its diagnosis is difficult. The average time from onset of symptoms to diagnosis is 18 months. Moreover, the prognosis of the disease depends on the early onset of specific treatment. The article describes a clinical case of POEMS-syndrome in a 53-year-old man, which illustrates the difficulties associated with the timely recognition of this unusual disease.

scholarly journals The Confusion between Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis as a Cause of Exfoliative Dermatitis: A Case Report

2021 ◽  
Vol 33 (3) ◽  
pp. 224
Author(s):  
Desiana Widityaning Sari ◽  
Cita Rosita Sigit Prakoeswa ◽  
Damayanti Damayanti ◽  
Sylvia Anggraeni ◽  
Menul Ayu Umborowati ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Clinical Manifestations ◽  
Clinical Findings ◽  
Pustular Psoriasis ◽  
History Taking ◽  
Exfoliative Dermatitis ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Physical Examinations ◽  
Erythematous Skin ◽  
Exanthematous Pustulosis

Background: Pustular psoriasis and Acute Generalized Exanthematous Pustulosis (AGEP) are grouped under pustular diseases, in which their clinical manifestations are similar. Those diseases can lead to exfoliative dermatitis. Purpose:To evaluate a specific histopathological examination in differentiating Pustular Psoriasis and AGEP. Case: A 55-year-old woman presented with sudden redness and diffused scaly skin with multiple pustules and also fever. She had taken Cefadroxil 2 days before the scales and pustules appeared. Leukocytosis and histopathological examination results from biopsy supported the diagnosis of AGEP. The patient was then hospitalized and received steroid therapy. Within the first week of tapering off, the scales disappeared but the pustules increased. After such clinical findings, the histopathological examination results were revisited and reassessed. Thus, we considered changing the diagnosis to Pustular Psoriasis, and the therapy was switched to Methotrexate. The patient had a better outcome, and the pustules slowly disappeared entirely. Discussion: It is often difficult to differentiate between the pustules in pustular psoriasis and AGEP unless by thorough history-taking and physical examinations. AGEP is characterized by a widespread of pustules with an acute febrile onset; while pustular psoriasis is an acute variant of psoriasis where pustules are spread over erythematous skin and accompanied by high fever and leukocytosis. Conclusion: Histopathological examination is the gold standard for the establishment of pustular psoriasis diagnosis. The histopathological characteristics of pustular psoriasis and AGEP are difficult to differentiate. Therefore, we need detailed history-taking and physical examination to establish the diagnosis.

Lucio Phenomenon: A Rare Manifestation of Leprosy in Selangor, Malaysia

2021 ◽  
Vol 5 (0-2) ◽  
pp. 20
Author(s):  
Shahrizan Majid Binti Allapitchai
Keyword(s):  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Skin Condition ◽  
Lepromatous Leprosy ◽  
Lower Limbs ◽  
Who Guidelines ◽  
Rare Manifestation ◽  
Hands And Feet ◽  
Multiple Ulcers ◽  
Made In

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, predominantly affecting the skin and peripheral nerves. Lucio phenomenon is a rare reactional state presenting in patient with lepromatous leprosy and described as acute cutaneous necrotising vasculitis. We discussed the case of a 38-year-old male patient presenting with oedematous and dusky discolouration of bilateral hands and feet associated with diffuse facial involvement. His skin condition gradually worsened to form multiple ulcers with bizarre shaped purpuric lesion over bilateral upper and lower limbs, trunk, and face. Histopathological examination of the skin biopsy showed multiple acid-fast bacilli and diagnosis of Lucio’s phenomenon was made in the background of lepromatous leprosy. He was treated with multi drug therapy (MDT) as recommended by the WHO guidelines. A better understanding of rarer manifestation of this illness is important for early diagnosis and to prevent significant morbidity associated with it.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S20

scholarly journals Concurrent primary and secondary myiasis on basal cell carcinoma

2012 ◽  
Vol 87 (2) ◽  
pp. 292-295 ◽  
Author(s):  
Adriana Andrade Raposo ◽  
Antônio Pedro Mendes Schettini ◽  
Cesare Massone
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histopathological Examination ◽  
Traumatic Injury ◽  
Skin Condition ◽  
Healthy Patient ◽  
Dorsal Region ◽  
Skin Cancers ◽  
Fly Larvae

Myiasis is a disease caused by infestation of fly larvae in human and other vertebrate tissues. It is a skin condition common in tropical and subtropical countries and its predisposing factors are: chronic diseases, immunodeficiency, poor hygiene, senility, psychiatric disorders, skin cancers and ulcerated mucosae. We report the case of a healthy patient who after traumatic injury of a preexisting lesion showed a tumor on the dorsal region parasitized by fly larvae. The histopathological examination performed for the diagnosis of skin neoplasm surprisingly revealed the presence of a partially degenerated larva with characteristics of Dermatobia hominis, suggesting an association of primary and secondary myiasis on basal cell carcinoma.

Spectrometric evaluation of post-mortem optical skin changes

2013 ◽  
Vol 128 (2) ◽  
pp. 361-367 ◽  
Author(s):  
Vera Sterzik ◽  
Lioudmila Belenkaia ◽  
Andreas W. Liehr ◽  
Michael Bohnert
Keyword(s):  
Post Mortem ◽  
Skin Changes

scholarly journals A Rare Case of Radicular Dens in Dente diagnosed by Clinical, Radiographic, Tomographic, and Histopathological Examinations

2017 ◽  
Vol 6 (1) ◽  
pp. 39-43
Author(s):  
Fabricio K de Carvalho ◽  
Ana PD Moreno ◽  
Jorge E León ◽  
Eduardo P Zanella ◽  
Alexandra M de Queiroz ◽  
...  
Keyword(s):  
Rare Case ◽  
Histopathological Examination ◽  
Treatment Plan ◽  
Final Diagnosis ◽  
Radiographic Examination ◽  
Supernumerary Tooth ◽  
Dental Anomaly ◽  
Dens In Dente ◽  
Tomography Scan ◽  
Dens Invaginatus

ABSTRACT Dens invaginatus is a dental anomaly caused by an invagination of enamel that affects in most of the cases the crown of the tooth. The treatment depends on the degree of invagination and morphological involvement. This report describes a dental anomaly affecting the permanent lower lateral incisor of a 13-year-old patient, which resulted in swelling, pain, and dental impaction. The initial radiographic examination suggested a gemination, a fusion with a supernumerary tooth or a dens invaginatus extending to the root. For more accurate diagnosis and treatment plan of this anomaly, computed tomography scan was performed, which revealed the presence of enamel in the root. Due to pain and the impossibility of performing an orthodontic traction, the treatment of choice in this case was dental extraction. The final diagnosis was confirmed by histopathological examination and revealed the rare occurrence of a radicular dens invaginatus. How to cite this article Moreno APD, de Carvalho FK, de Queiroz AM, León JE, Zanella EP, De Rossi A. A Rare Case of Radicular Dens in Dente diagnosed by Clinical, Radiographic, Tomographic, and Histopathological Examinations. Int J Experiment Dent Sci 2017;6(1):39-43.

scholarly journals Exfoliative dermatitis due to dermatophytosis

2021 ◽  
Vol 15 (02) ◽  
pp. 306-309
Author(s):  
Risa Miliawati Nurul Hidayah ◽  
Andini Dwikenia Anjani ◽  
Lies Marlysa Ramali ◽  
Oki Suwarsa ◽  
Hendra Gunawan
Keyword(s):  
Histopathological Examination ◽  
Case Reports ◽  
Skin Surface ◽  
Entire Body ◽  
Fungal Culture ◽  
Exfoliative Dermatitis ◽  
Keratinized Tissue ◽  
Direct Microscopic Examination ◽  
History Of ◽  
Total Body

Exfoliative dermatitis (ED) or erythroderma is defined as diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface, which can be caused by variety of systemic and cutaneous diseases, such as infection, including dermatophytosis. Dermatophytosis is a superficial fungal infection of keratinized tissue caused by dermatophytes. There are only few case reports of ED due to dermatophytosis in literature. A 39-year-old male present with history of diffuse erythematous macules and scales almost on entire body due to dermatophytosis was reported. The diagnosis of dermatophytosis was confirmed by direct microscopic examination, fungal culture, and histopathological examination. Patient was treated with 2% ketoconazole shampoo and two pulses of 1-week of 200 mg itraconazole twice a day for each month. Clinical improvement was showed on the 7th day of observation characterized by decreasing of erythematous macules and scales. Mycological and clinical improvements were obtained on the 29th day of observation. The etiology of ED should be determined in order to give an appropiate treatment.

scholarly journals An Unusual Case of Ameloblastoma observed in the Left Anterior Mandible

2014 ◽  
Vol 15 (6) ◽  
pp. 775-778
Author(s):  
Omer Gunhan ◽  
Emin Murat Canger ◽  
Peruze Çelenk ◽  
Emel Bulut
Keyword(s):  
Unusual Case ◽  
Panoramic Radiography ◽  
Histopathological Examination ◽  
Small Dimension ◽  
Chief Complaint ◽  
Radiographic Examination ◽  
Radiolucent Lesion ◽  
Odontogenic Neoplasm ◽  
Anterior Mandible ◽  
Slow Growing

ABSTRACT Aim To report a small intaalveolar ameloblastoma which resembled cystic lesion, and to emphasize the value of Computed tomography (CT) in radiographic examination. Background Ameloblastoma is a slow-growing, locally invasive odontogenic neoplasm that accounts for approximately 10% of all tumors detected in the jaws. Radiographically, those tumors are usually well-defined. Computerized tomography is highly recommended to confirm the diagnosis. Case description A 48-year-old female attended with a chief complaint of painless swelling in the left anterior of mandible, 1 month duration. In intraoral examination, non-fluctuant, immobile, approximately 1 × 1 cm in dimension, painless, swelling which had a bone-like hardness and located in the mandibular canine region was detected. Panoramic radiography revealed a well circumscribed unilocular radiolucent lesion located in the inter-radicular area of left mandibular lateral and canine teeth. In CT examination it was realized that the lesion was multilocular. Histopathological examination of the biopsy specimen was reported as ameloblastoma. Clinical significance It is extremely difficult to find such an ameloblastoma in small dimension in alvolar bone. How to cite this article Canger EM, Çelenk P, Bulut E, Günhan Ö. An Unusual Case of Ameloblastoma observed in the Left Anterior Mandible. J Contemp Dent Pract 2014;15(6):775-778.

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