Bordetella Pertussis Antibody Levels in DPT/Pentavalent Immunized Preschool Nigerian Children: A Cross-Sectional Study

2019 ◽  
Vol 15 (01) ◽  
pp. 011-015
Author(s):  
Glory Ekpo Bassey ◽  
Emmanuel Eyo Ekanem ◽  
Henry Chima Okpara ◽  
Komomo Ibor Eyong
Keyword(s):  
Pertussis Toxin ◽  
Bordetella Pertussis ◽  
Age Groups ◽  
Booster Vaccination ◽  
Rapid Decline ◽  
Age Group ◽  
Igg Antibodies ◽  
Cross Sectional ◽  
Nigerian Children ◽  
Antibody Levels

AbstractPertussis is a vaccine-preventable disease and antibodies formed are known to decline with time. The aim of this study was to measure Bordetella pertussis/toxin immunoglobulin G (IgG) antibodies in different age groups of Nigerian children and determine the age at which booster dose may be required. A total of 422 children, aged 6 to 60 months, were tested for the presence of B. pertussis/toxin IgG antibodies by ELISA (enzyme-linked immune sorbent assay). The highest positivity rate was in the 6 to 11 months of age group, while the highest negativity rate was in the age group of 24 to 35 months. We conclude that B. Pertussis/toxin IgG antibodies response is weak in Nigerian children after three doses of DPT (diphtheria, pertussis, and tetanus)/pentavalent vaccination, and there is a rapid decline of antibody levels between 12 and 35 months. We recommend that booster vaccination should be given at 12 to 15 months of age.

scholarly journals Seroprevalence of Bordetella pertussis toxin antibodies in children and adolescents in Tunis, Tunisia

2019 ◽  
Vol 147 ◽  
Author(s):  
I. Ben Fraj ◽  
M. Zghal ◽  
M. Hsairi ◽  
A. Kechrid ◽  
H. Smaoui
Keyword(s):  
Children And Adolescents ◽  
Pertussis Toxin ◽  
Bordetella Pertussis ◽  
Disease Transmission ◽  
Booster Vaccination ◽  
Health Concern ◽  
Enzyme Linked Immunosorbent Assay ◽  
Recent Infection ◽  
Cross Sectional ◽  
Recent Exposure

AbstractPertussis remains a public health concern in most countries. This cross-sectional study aims to investigate the distribution of pertussis toxin antibodies (anti-PT IgG) in Tunisian children and adolescents aged 3–18 years, to define optimal age for booster vaccination. Anti-PT IgG concentrations of enrolled participants were measured using commercial enzyme-linked immunosorbent assay. Concentrations were classified as: indicative of current/recent infection if ⩾100 IU/ml, indicative of recent exposure to Bordetella pertussis within the last year if 40–100 IU/ml and less likely revealing a recent exposure to B. pertussis if <40 IU/ml. Between March and June 2018, a total of 304 participants (mean age: 9.3 years) were included in this study. Overall, 12.8% (95% confidence interval (CI) 9.1%–16.6%) were seropositive (IgG levels ⩾40 IU/ml). Among them, 14.7% (95% CI 2.3%–23.3%) had levels indicative of a current/recent infection. The multivariate Poisson regression analysis suggested associations between female gender, as well as age group 13–18 years and 3–5 years and higher anti-PT IgG concentrations. Our results are consistent with the notion that vaccine-induced immunity decline, as well as circulation of pertussis among school children and adolescents enables them to be reservoirs of infection and disease transmission to vulnerable infants. Booster dose of acellular pertussis vaccine for school entrants is therefore recommended.

scholarly journals Enhanced Bordetella pertussis acquisition rate in adolescents during the 2012 epidemic in the Netherlands and evidence for prolonged antibody persistence after infection

2017 ◽  
Vol 22 (47) ◽  
Author(s):  
Saskia van der Lee ◽  
Susanne P. Stoof ◽  
Mariette B. van Ravenhorst ◽  
Pieter G.M. van Gageldonk ◽  
Nicoline A.T. van der Maas ◽  
...  
Keyword(s):  
The Netherlands ◽  
Pertussis Toxin ◽  
Bordetella Pertussis ◽  
Serum Samples ◽  
Recent Infection ◽  
Pertussis Infection ◽  
Cross Sectional ◽  
Acquisition Rate ◽  
Antibody Persistence ◽  
Antibody Levels

Introduction In 2012 a large epidemic of pertussis occurred in the Netherlands. We assessed pertussis toxin (PT) antibody levels in longitudinal serum samples from Dutch 10–18 year-olds, encompassing the epidemic, to investigate pertussis infection incidence. Methods: Blood was sampled in October 2011 (n = 239 adolescents), then 1 year (2012; n = 228) and 3 years (2014; n = 167) later. PT-IgG concentrations were measured by immunoassay and concentrations ≥50 IU/mL (seropositive) assumed indicative of an infection within the preceding year. Results: During the 2012 epidemic, 10% of participants became seropositive, while this was just 3% after the epidemic. The pertussis acquisition rate proved to be sixfold higher during the epidemic (97 per 1,000 person-years) compared with 2012–2014 (16 per 1,000 person-years). In 2012, pertussis notifications among adolescents nationwide were 228/100,000 (0.23%), which is at least 40 times lower than the seropositivity percentage. Remarkably, 17 of the 22 seropositive participants in 2011, were still seropositive in 2012 and nine remained seropositive for at least 3 years. Discussion: Longitudinal studies allow a better estimation of pertussis infections in the population. A PT-IgG concentration ≥50 IU/mL as indication of recent infection may overestimate these numbers in cross-sectional serosurveillance and should be used carefully.

scholarly journals Ten-year trends of hypertension treatment and control rate in Korea

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kwang-il Kim ◽  
Eunjeong Ji ◽  
Jung-yeon Choi ◽  
Sun-wook Kim ◽  
Soyeon Ahn ◽  
...  
Keyword(s):  
Age Groups ◽  
Favorable Effect ◽  
Age Group ◽  
Hypertension Treatment ◽  
Treatment Rate ◽  
Cross Sectional ◽  
The Past ◽  
Nationally Representative ◽  
Multistage Sampling ◽  
And Control

AbstractWe analyzed the Korean National Health and Nutrition Examination Survey (KNHANES) database to determine the trends of hypertension treatment and control rate in Korea over the past 10 years. In addition, we tried to investigate the effect of chronic medical conditions on hypertension management. We investigated the hypertension prevalence, awareness, treatment, and control rate from 2008 to 2017. KNHANES, which uses a stratified multistage sampling design, is a cross-sectional, nationally representative survey conducted by the Korean government. A total of 59,282 adults (≥ 20 years) were included, which was representative of the total population of around 40 million Koreans per year. The mean age was 50.7 ± 16.4 years and 42.6% were male. The prevalence of hypertension, hypercholesterolemia, diabetes mellitus, and obesity significantly increased over the 10 years. During this period, the hypertension treatment and control rate significantly improved. Hypertension treatment rate was significantly lower in the younger age group compared to the older age group, but the control rate among the treated patients was not significantly different between age groups. The treatment and control rates of hypertension were higher in patients with multimorbidity, which implies that it has a favorable effect on the treatment and control of hypertension. Hypertension treatment and control rate have improved over the past 10 years. The higher treatment and control rate in patients with multimorbidity suggest that the more aggressive surveillance might be associated with the improvement of hypertension treatment and control rate in Korea.

scholarly journals Comparison of Prevalence of Periodontitis with Different Indices in Population of District Ghaziabad

2016 ◽  
Vol 04 (01) ◽  
pp. 023-030
Author(s):  
Vimal Kumar ◽  
Pallak Arora ◽  
Manish Khatri ◽  
Shivani Sharma ◽  
Sumit Malhotra ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Total Population ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Sample Population ◽  
Age Group ◽  
Cross Sectional ◽  
Multi Stage ◽  
Younger Age ◽  
Study Population

Abstract Objective: To estimate the prevalence of periodontal disease with different indices. Methods & materials: The study population consisted of multistage stratified random sample of 1300 subjects from total population of district Ghaziabad. A cross-sectional study was conducted with multi stage stratified random sampling techniques to select the sample population. The subjects were divided into different age groups and the periodontal assessment was made on the basis of CPITN index and ESI Index. Results: The CPITN has shown to estimate incorrect periodontal disease prevalence because of its underestimation of the disease severity. A huge difference was noticed in the prevalence rate of periodontitis when subjects were examined with ESI index. Conclusion Periodontal disease was found to be highly prevalent in the study population and severity of disease increased with age. More number of subjects in younger age group were found to be healthy.

scholarly journals Study on factors affecting fertility of Bangladeshi women

2019 ◽  
Vol 1 (Number 2) ◽  
pp. 6-10
Author(s):  
Monowar Ahmad Tarafdar ◽  
Nadia Begum ◽  
Shila Rani Das ◽  
Sultana Begum ◽  
Mehruba Afrin ◽  
...  
Keyword(s):  
Middle Class ◽  
Rural Area ◽  
Age Groups ◽  
Wealth Index ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Age Group ◽  
Cross Sectional ◽  
Lower Middle Class ◽  
Factors Affecting

This is a cross sectional study conducted among Currently Married Women of Reproductive Age (CMWRA) with a sample size of 476 selected purposively using a semi-structured questionnaire in 2018 at Moulvibazar Sadar to explore the factors affecting fertility. The result shows that 55.26% respondents were within 35 years age whereas only 4.28% from age group 46-49 years age group, 33% of the respondents got married at <16 years of age and 18.70% were illiterate, 47.90% had primary education. It is evident that 76% of the respondents were from rural area; 88% were Muslims, 29.41% from lower middle class followed by upper middle class (25.42%) and poorest comprised only 7.56%. The result explored that 73.91% of the respondents were from age group 41-45 got married before 16 years of age followed by 36-40 years (68.24%), 46-49 years (66%), 20-25 and 26-30 years age groups 52.38% and 52.75% respectively; 73.33% of respondents from rural area got married at <16 years of age, 68.42% of the Muslim at <16 years. The study explored that 96.39% from poorer section and 83.33% from poorest section got married at <16 years of age. Current study revealed that 82.91% of the respondents having secondary education got married before 16 years of age followed by illiterate (82.02%). It is explored that the age at marriage is statistically associated with residence, education, wealth index and religion (p= 0.001, 0.03, 0.001, 0.001 respectively). We conclude that the sociodemographic condition contributes mostly to fertility differentials in Bangladesh.

scholarly journals Study of Cervical Length in Bangladeshi Cadaver

2016 ◽  
Vol 5 (2) ◽  
pp. 26-28
Author(s):  
Zubaida Gulshan Ara ◽  
ASM Shafiqul Islam ◽  
Umme Kulsum Sharmin Zaman ◽  
Anjuman Ara ◽  
Reeva Aireen Busreea
Keyword(s):  
Uterine Cervix ◽  
Anatomical Variation ◽  
Age Groups ◽  
Sampling Technique ◽  
Descriptive Study ◽  
Cervical Length ◽  
Age Group ◽  
Cross Sectional ◽  
Medical College ◽  
Female Genital

This cross sectional descriptive study was done to see the length of the cervix in Bangladeshi cadaver to find out the anatomical variation and to compare it with other study findings. 60 post mortem specimens containing female genital organs particularly uterine cervix were collected by purposive sampling technique from cadavers of different age groups. All the collected specimens were fixed in 10% formalin solution. This study was carried out in the department of Anatomy, Mymensingh Medical College from July 2006 to June 2007. Both gross and fine dissections were performed to measure the length of the uterine cervix. We compare our study findings with that of the references. Maximum mean length of the cervix was found in the 13-45 years age group. It was 2.89 cm. CBMJ 2016 July: Vol. 05 No. 02 P: 26-28

scholarly journals Age and sex variation in visceral adipose tissue

2019 ◽  
Vol 6 (1) ◽  
pp. 101
Author(s):  
Pallavi Panchu ◽  
Biju Bahuleyan ◽  
Rose Babu ◽  
Vineetha Vijayan
Keyword(s):  
Adipose Tissue ◽  
Visceral Fat ◽  
Metabolic Disorders ◽  
Age Groups ◽  
Fat Distribution ◽  
Age Group ◽  
Cross Sectional ◽  
Younger Age ◽  
The Difference ◽  
Gender Pattern

Background: Adipose tissue mainly visceral fat is said to be harmful and acts as a harbinger of metabolic disorders. A changing trend is seen in the recent decades with decreasing incidence of metabolic disorders in men even though visceral fat is said to be higher in them. Sex hormones may influence the deposition pattern of adipose tissue. The aim of this study was to observe effects of age on visceral fat and to know if the difference in gender pattern of fat distribution is maintained throughout life or disappears after menopause.Methods: This cross-sectional observational study was conducted in Thrissur on 385 apparently healthy subjects using Omron body composition analyser. Data was analysed using SPSS 20.0 version. The tests employed were NOVA, independent samples t-test.Results: In each age group, men had significantly higher visceral fat than females. As age increased, visceral fat increased significantly in both genders. In each group, except for younger age groups, VF levels were equal in men and women.Conclusions: Visceral fat is higher in men and this difference is seen in all age groups. As age increases, visceral fat levels also increased in men and women. The distribution of visceral fat is such that a greater number of men have high to very high levels at a younger age group, a feature observed in women only in the peri and post-menopausal age. Adoption of an active lifestyle coupled with healthy diet should protect against onset of metabolic disorders.

scholarly journals Sociodemographic Analysis of Neural Tuberculosis in Brazil from 2010 to 2020

2021 ◽  
Author(s):  
Raissa Barreto Lima ◽  
Thaís Machado Belitardo de Carvalho ◽  
Matheus Campos Ribeiro de Souza ◽  
Lara Teixeira de Oliveira ◽  
Ana Carolina Pachêco de Menezes Rios ◽  
...  
Keyword(s):  
Information System ◽  
Extrapulmonary Tuberculosis ◽  
Age Groups ◽  
Severe Form ◽  
Sociodemographic Characteristics ◽  
Age Group ◽  
The South ◽  
Cross Sectional ◽  
Prevention And Health Promotion ◽  
Using Data

Background: Neural tuberculosis is an infection of the central nervous system caused by the bacterium Mycobacterium tuberculosis. Bearing in mind that neural tuberculosis is the most severe form of extrapulmonary tuberculosis and results in significant morbidity and mortality rates, it is important to analyze its sociodemographic characteristics in Brazil. Objectives: To describe the sociodemographic characteristics of neural tuberculosis cases in Brazil in the period from 2010 to 2020. Design and Setting: Cross-sectional, retrospective, and descriptive study, carried out using data collected from the Notifiable Diseases Information System (SINAN) and the Hospital Information System (SIH / SUS) of confirmed cases and hospitalizations for neural tuberculosis. Methods: Variables used: region, sex, age group, color/race and year of service. Results: In the period from 2010 to 2020, the number of notified cases of meningoencephalic tuberculosis was 7.451, with mean cases per year of 677.36. The Southeast region was the most affected with 43.8% of the total cases, followed by the South and Northeast regions, with 24.1% and 20.1%, respectively. There was a wide predominance in individuals aged 30-39 years (42.8%) and in the age group 40-59 years (35.9%). The male sex was the most affected with 63.3% of the total. Conclusions: The study shows a predominance of cases in the South and Southeast regions, with a significant prevalence of males and age groups of 20- 59. This could be an alert for new prevention and health promotion strategies for the most affected groups.

scholarly journals A cross-sectional study on morbidity status among school going adolescents in Thiruvallur district, Tamil Nadu

2019 ◽  
Vol 6 (12) ◽  
pp. 5201
Author(s):  
Sathish Dev D. ◽  
Sugantha Valli M. ◽  
Gnana Sezhian M. ◽  
Suganya E.
Keyword(s):  
Tamil Nadu ◽  
Gastrointestinal Disease ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Health Problems ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Wide Range ◽  
Tract Infections

Background: Adolescents represent about 21.8 percent of India’s population. Various health risks with potentially life-threatening consequences become prominent in this age group. This study was undertaken with the objective to determine the morbidity profile of school going adolescents in Tamil Nadu.Methods: This descriptive, cross sectional study was planned and conducted from January 2016 to August 2017. The study population included 987 adolescent boys and girls aged between 10 to 19 years studying in high and higher secondary Government schools of Thiruvallur district of Tamil Nadu. Semi-structured questionnaire was used as data collection tool.Results: The mean age groups of this school going adolescent are 14.2 yrs. In the present study 583 (59%) of the study participants were affected by one or more morbidity condition. Among them, 395 (67.7%) were in the age group 10-14 years and 188 (32.2%) in the age group 15-19 years. 122 (21%) and 461 (79.1%) of male and female were affected respectively. In the present study, fever (21%) was the commonest reported morbidity followed by acute respiratory infection (15.7%) and acute gastrointestinal disease (13. 4%).Conclusions: This study shows that adolescents are prone to a wide range of morbidity conditions. Apart from respiratory and gastro intestinal diseases, reproductive tract infections and sexual health problems are important morbidities affecting this age group. There is strong need to sensitize health care practitioners at all levels, in both government and private sectors towards health problems in adolescent age groups.

scholarly journals Sex differences in non-communicable disease prevalence in China: a cross-sectional analysis of the China Health and Retirement Longitudinal Study in 2011

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e017450 ◽  
Author(s):  
Yan Liu ◽  
Guofeng Liu ◽  
Hongjiang Wu ◽  
Weiyan Jian ◽  
Sarah H Wild ◽  
...  
Keyword(s):  
Sex Differences ◽  
Heart Disease ◽  
Longitudinal Study ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Communicable Disease ◽  
Age Groups ◽  
Sociodemographic Factors ◽  
Age Group ◽  
Cross Sectional

ObjectivesTo describe the sex differences in the prevalence of non-communicable diseases (NCDs) in adults aged 45 years or older in China.DesignCross-sectional study.SettingNationally representative sample of the Chinese population 2011.Participants8401 men and 8928 women over 45 years of age who participated in the first wave of the China Health and Retirement Longitudinal Study (CHARLS).Outcome measuresSelf-reported data on overall health and diagnosis of hypertension, dyslipidaemia, diabetes, heart disease, stroke, chronic lung disease, cancer or arthritis. Sex differences in NCDs were described using logistic regression to generate odds ratios (OR) with adjustment for sociodemographic factors and health-related behaviours. All analyses were stratified by age group for 45–64-year-old and ≥65-year-old participants.ResultsIn both age groups, men reported better overall health than women. The crude prevalence of heart disease, cancer and arthritis was higher while that of stroke and chronic lung disease was lower in women than in men. After adjustment, ORs (95% CI) for the 45–64 and ≥65 year age groups were 0.70 (0.58 to 0.84) and 0.66 (0.54 to 0.80), respectively, for arthritis for men compared with women. In contrast, ORs were 1.66 (1.09 to 2.52) and 2.12 (1.36 to 3.30) for stroke and 1.51 (1.21 to 1.89) and 1.43 (1.09 to 1.88) for chronic lung disease for men compared with women. ORs for heart disease (0.65 (0.52 to 0.80)) were lower in men than in women only in the 45–64 year age group.ConclusionsOdds of arthritis were lower while those of stroke and chronic lung disease were higher in men than in women in both age groups. However, odds of heart disease were lower in men than in women, but only in the group of individuals aged 45–64 years.

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