scholarly journals Evaluation of Salivary Interleukin-12, Interleukin-23 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

2021 ◽  
Vol 10 (02) ◽  
pp. 91-95
Author(s):  
Tahereh Nosratzehi ◽  
Ebrahim Alijani ◽  
Neda Hassanpoor

Abstract Objectives The present study aimed to evaluate interleukin-12 (IL-12) and IL-23 in the saliva of patients with oral lichen planus (OLP) and oral squamous cell carcinoma (SCC). Materials and Methods Thirty cases with clinical and histopathological OLP (bilateral lesions, papular and reticular lesions, and Wickham lines) (Group A), 30 with oral SCCs (OSCCs) (Group B), and 30 with no history of oral cancer, other lesions, or lichen planus (Group C) were enrolled at the Department of Oral Medicine School of Dentistry, Zahedan, Iran. The whole unstimulated saliva was collected and the salivary concentration of IL-12 and IL-23 was measured using an enzyme-linked immunosorbent assay in the laboratory. Statistical Analysis Data were analyzed using Kruskal–Wallis, Mann–Whitney tests, and Pearson’s correlation coefficients. Results In the present study, salivary IL-12 and IL-23 levels were higher in OSCC patients than in OLP and healthy individuals. Conclusions The results show that although IL-23 and IL-12 cytokines have an important role in the pathogenesis of chronic immunity and inflammatory diseases, further studies are required to assess matrix metalloproteinase links with tumor invasion.

ORL ro ◽  
2020 ◽  
Vol 3 (48) ◽  
pp. 15
Author(s):  
Corina I. Cucu ◽  
Liliana Gabriela Popa ◽  
Călin Giurcăneanu ◽  
Vladimir S. Ibric Cioran ◽  
Cristina Beiu ◽  
...  

Oral Diseases ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Shigeo Ishikawa ◽  
Masahiro Sugimoto ◽  
Kaoru Edamatsu ◽  
Ayako Sugano ◽  
Kenichiro Kitabatake ◽  
...  

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0215055 ◽  
Author(s):  
Christopher G. Németh ◽  
Christoph Röcken ◽  
Reiner Siebert ◽  
Jörg Wiltfang ◽  
Ole Ammerpohl ◽  
...  

2013 ◽  
Vol 169 (1) ◽  
pp. 106-114 ◽  
Author(s):  
S. Segura ◽  
E. Rozas-Muñoz ◽  
A. Toll ◽  
G. Martín-Ezquerra ◽  
E. Masferrer ◽  
...  

2001 ◽  
Vol 18 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Michele D. Mignogna ◽  
Lorenzo Lo Muzio ◽  
Lucio Lo Russo ◽  
Stefano Fedele ◽  
Elvira Ruoppo ◽  
...  

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