Salivary Atopy Biomarkers in Patients with Geographic Tongue

Abstract Objectives Geographic tongue is the mucositis of the dorsal surface of the tongue with no definite etiology, although it may be associated with atopic conditions. In this study, the salivary immunoglobulin E (IgE) and eosinophilic cationic protein (ECP) levels were assessed in patients with geographic tongue to examine the relationship between this condition and allergy-related biomarkers. Materials and Methods In this case-control study, unstimulated saliva was collected from 45 geographic tongue patients and 45 controls, and the salivary IgE and ECP levels were assessed. The data were analyzed with SPSS 20.0 using the Mann–Whitney test with a significance level of p < 0.05. Results The salivary IgE level in the case and control groups was 123.76 ± 8.1 and 74.34 ± 6.2 IU/mL, respectively, and the salivary ECP level was 9.4 ± 6.0 and 7.6 ± 3.2 ng/mL, respectively. There was a statistically significant difference between the two groups in terms of salivary IgE (p = 0.007) and ECP (p = 0.001) levels. Conclusion Salivary IgE and ECP levels increase in patients with geographic tongue. They can, therefore, be used for the initial diagnostic workup and to investigate the possible association of geographic tongue with allergic reactions.

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Correlation Between CCND1 Gene Polymorphism and Genetic Susceptibility to Gastric Cancer in Chinese Population

10.21203/rs.3.rs-128247/v1 ◽

2020 ◽

Author(s):

Huiwen Pan ◽

Xuyu Gu ◽

Chen Zou ◽

Keping Chen ◽

Yu Fan

Keyword(s):

Gastric Cancer ◽

Gene Polymorphism ◽

Case Control Study ◽

Control Groups ◽

Ccnd1 Gene ◽

Significant Difference ◽

And Control ◽

The Relationship ◽

Normal Controls ◽

Control Study

Abstract Objective: The relationship between Cyclin D1 gene (CCND1) rs9344 polymorphism and susceptibility to gastric cancer (GC) is investigated.Methods: In a case-control study, we selected 577 cases of GC from The People's Hospital Affiliated to Jiangsu University in China along with 678 normal controls. Blood DNA was extracted and PCR amplified, gene polymorphism was determined using Snapshot method.Results: Analysis reveals significant difference in smoking between GC and control groups (P=0.006), however, not on polymorphism (P＞0.05). Conclusion: Smoking is associated with gastric cancer, whereas CCND1 rs9344 polymorphism does not implicate susceptibility of gastric cancer.

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Dietary diversity score is inversely related to the risk of polycystic ovary syndrome in Tehranian women: a case-control study

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2021-0359 ◽

2021 ◽

pp. 1-6

Author(s):

Sahel Soodi ◽

Seyed Ali Keshavarz ◽

Sedighe Hosseini ◽

Behnood Abbasi

Keyword(s):

Polycystic Ovary Syndrome ◽

Case Control Study ◽

Dietary Diversity ◽

Polycystic Ovary ◽

Case Control ◽

Control Groups ◽

Ovary Syndrome ◽

And Control ◽

The Relationship ◽

Control Study

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age and is affected by various dietary factors. Therefore, this study aimed to investigate the relationship between dietary diversity score (DDS) and the risk of PCOS. Our case-control study was conducted in the summer and autumn of 2019 in Taleghani and Arash hospitals in Tehran, Iran. A total of 494 participants (203 cases and 291 controls) were included in the study. Thereafter, their demographic information, dietary intake, and anthropometric and physical activity assessments were gathered. A validated semi-quantitative food frequency questionnaire was then used to calculate the DDS by scoring 5 food groups. To evaluate the risk of PCOS in association with DDS, the subjects were categorized based on the quartile cut-off points of the DDS. The mean ± SD age of the participants in both the case and control groups was 28.98 ± 5.43 and 30.15 ± 6.21 years, while mean ± SD body mass index was 25.74 ± 5.44 and 23.65 ± 3.90 kg/m2, respectively. The comparison between the case and control groups indicated that total DDS was 5.19 ± 1.19 for the cases and 5.51 ± 1.19 for the controls. The comparison of DDS in the highest versus the lowest quartiles showed a decreased risk of PCOS (p < 0.05). We demonstrated an inverse association between DDS and PCOS compared with the control group. Furthermore, a higher DDS was significantly associated with a lower risk of PCOS (odds ratio = 0.40). Novelty: This is the first investigation on the relationship between DDS and PCOS. Results depicted an inverse relationship between DDS and PCOS.

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Plasma kisspeptin and ghrelin levels in puberty variant cases

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2016-0127 ◽

2017 ◽

Vol 30 (5) ◽

Cited By ~ 2

Author(s):

Erdal Kurnaz ◽

Yaşar Şen ◽

Süleyman Aydın

Keyword(s):

Serum Levels ◽

Control Group ◽

Control Groups ◽

Premature Thelarche ◽

Premature Adrenarche ◽

Significant Difference ◽

And Gender ◽

And Control ◽

Relationship Of ◽

The Relationship

AbstractBackground:The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.Methods:A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.Results:When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.Conclusions:Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.

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Hair nicotine concentration of cats with gastrointestinal lymphoma and unaffected control cases

Veterinary Record ◽

10.1136/vr.105564 ◽

2020 ◽

Vol 186 (13) ◽

pp. 414-414 ◽

Cited By ~ 1

Author(s):

Victoria Smith ◽

Clare Knottenbelt ◽

David Watson ◽

Dominic J Mellor ◽

Alexandra Guillen Martinez ◽

...

Keyword(s):

Case Control Study ◽

Control Group ◽

Gastrointestinal Lymphoma ◽

Control Groups ◽

Nicotine Concentration ◽

Hair Samples ◽

Significant Difference ◽

Unaffected Control ◽

And Control ◽

Control Study

BackgroundA previous study showed an association between owner-reported exposure to environmental tobacco smoke (ETS) and lymphoma in cats. This study aimed to investigate the association between ETS exposure and gastrointestinal lymphoma in cats, using hair nicotine concentration (HNC) as a biomarker.MethodsThis was a prospective, multi-centre, case–control study. Gastrointestinal lymphoma was diagnosed on cytology or histopathology. Hair samples were obtained from 35 cats with gastrointestinal lymphoma and 32 controls. Nicotine was extracted from hair by sonification in methanol followed by hydrophilic interaction chromatography with mass spectrometry. Non-parametric tests were used.ResultsThe median HNC of the gastrointestinal lymphoma and control groups was not significantly different (0.030 ng/mg and 0.029 ng/mg, respectively, p=0.46). When the HNC of all 67 cats was rank ordered and divided into quartiles, there was no significant difference in the proportion of lymphoma cases or controls within these groups (p=0.63). The percentage of cats with an HNC≥0.1 ng/mg was higher for the lymphoma group (22.9%) than the control group (15.6%) but failed to reach significance (p=0.45).ConclusionA significant association was not identified between HNC (a biomarker for ETS) and gastrointestinal lymphoma in cats; however, an association may exist and further studies are therefore required.

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Assesment of Endometrial Vascularization with Immunohistochemical CD34 Assay in Recurrent Pregnancy Loss: A Case Control Study

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2016.664 ◽

2017 ◽

pp. 1

Author(s):

Emine Aydın ◽

Taner Usta

Keyword(s):

Pregnancy Loss ◽

Recurrent Pregnancy Loss ◽

Case Control Study ◽

Transmembrane Protein ◽

Vessel Diameter ◽

Control Group ◽

Control Groups ◽

Significant Difference ◽

And Control ◽

Control Study

Objectives: We compared the endometrial vascularization in hysteroscopic endometrial samplings between recurrent pregnancy loss (RPL) and control group.Study Design: We prospectively evaluated hysteroscopic endometrial samplings from RPL and control groups. CD34 transmembrane protein was used for evaluating endometrial vascularization. The vascularization was assessed based on thickness of vessels, diameter of the largest vessel, and number of vessels per mm2 in CD34-stained slides.Results: There was no significant difference in demographic findings and vascularization, such as largest vessel diameter (p: 0.572), and number of vessels per mm2 (p: 0.982) between the two groups.Conclusion: The cycling endometrium is a highly angiogenic tissue and may play a role in the etiology of RPL. However, we find a weak relationship between endometrial vascularization and RPL.

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Prostate-specific antigen and (free prostate-specific antigen/ prostate-specific antigen) ratio in patients with Benign Prostatic Hyperplasia and Prostate Cancer

Baghdad Journal of Biochemistry and Applied Biological Sciences ◽

10.47419/bjbabs.v1i01.28 ◽

2020 ◽

Vol 1 (01) ◽

pp. 17-25

Author(s):

Amal A. Hussein ◽

Rayah S. Baban ◽

Alaa G. Hussein

Keyword(s):

Prostate Cancer ◽

Prostate Specific Antigen ◽

Case Control Study ◽

Specific Antigen ◽

Control Group ◽

Inverse Association ◽

Control Groups ◽

Significant Difference ◽

And Control ◽

Control Study

Background: Prostate cancer is one of the most common cancers in menworldwide. Many markers are suggested as markers of prostate cancer with differentspecificity and sensitivity.Objective : The present study’s main aim is to examine the possible utility ofprostate-specific antigen indices as markers of prostate cancer.Methods: A case-control study was conducted in the Department of Chemistry andBiochemistry, College of Medicine, Al- Nahrain University, Baghdad, Iraq from July2018 till March 2019, includes 84 subjects divided into three groups:Twenty Four patients with prostate cancer (PCA), thirty patients with benignprostatic hyperplasia (BPH) and thirty healthy subjects as a control group wereexamined in this study.Thirty healthy volunteer subjects were asked to be involved in this study as a controlgroup. Blood samples from these patients were collected before obtaining a prostaticbiopsy. Serum PSA, fPSA levels were quantified by the ELISA technique.Results: PSA cut-off value was found to be more than 9.57 ng/ml for Prostate Cancerpatients, values range between 3.17 - 9.57 ng/ml for BPH patients and cut-off valuefor control was found to be less than 3.17 ng/ml, while serum (fPSA/PSA) % cut-offvalue was less than 11.1% for Prostate Cancer patients, values range between 11.1% -31 % for BPH patients, and cut-off value was greater than 31% for the control group.Conclusion: There is a highly significant difference in serum PSA levels and(fPSA/PSA)% between the prostate cancer and control groups. Body mass indexshowed an inverse association with the risk of prostate cancer.

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Enteral L-Arginine and Glutamine Supplementation for Prevention of NEC in Preterm Neonates

International Journal of Pediatrics ◽

10.1155/2015/856091 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 9

Author(s):

M. S. El-Shimi ◽

H. A. Awad ◽

M. A. Abdelwahed ◽

M. H. Mohamed ◽

S. M. Khafagy ◽

...

Keyword(s):

Oral Intake ◽

Glutamine Supplementation ◽

Preterm Neonates ◽

Control Group ◽

Control Groups ◽

Significant Difference ◽

And Control ◽

Preventive Role ◽

Control Study ◽

Group Serum

Objective. Evaluating the efficacy and safety of arginine and glutamine supplementation in decreasing the incidence of NEC among preterm neonates.Methods.Prospective case-control study done on 75 preterm neonates ≤34 weeks, divided equally into L-arginine group receiving enteral L-arginine, glutamine group receiving enteral glutamine, and control group. Serum L-arginine and glutamine levels were measured at time of enrollment (sample 1), after 14 days of enrollment (sample 2), and at time of diagnosis of NEC (sample 3).Results. The incidence of NEC was 9.3%. There was no difference in the frequency of NEC between L-arginine and control groups (P>0.05). NEC was not detected in glutamine group; L-arginine concentrations were significantly lower in arginine group than control group in both samples while glutamine concentrations were comparable in glutamine and control groups in both samples. No significant difference was found between groups as regards number of septic episodes, duration to reach full oral intake, or duration of hospital stay.Conclusion.Enteral L-arginine supplementation did not seem to reduce the incidence of NEC. Enteral glutamine may have a preventive role against NEC if supplied early to preterm neonates. However, larger studies are needed to confirm these findings. This work is registered in ClinicalTrials.gov (ClinicalTrials.gov Identifier:NCT01263041).

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Effect of a mobile-based educational app on blood pressure of patients with hypertension

BMJ Military Health ◽

10.1136/bmjmilitary-2020-001577 ◽

2020 ◽

pp. e001577

Author(s):

Fereshteh Falah ◽

S A Sajadi ◽

A H Pishgooie

Keyword(s):

Blood Pressure ◽

Military Personnel ◽

Intervention Group ◽

Control Group ◽

Control Groups ◽

Chi Square ◽

Significance Level ◽

Significant Difference ◽

And Control ◽

Paired T Test

BackgroundHypertension is known as one of the most important non-communicable pervasive diseases.ObjectiveThe purpose of the present study was to determine the effect of a mobile-based educational app on the blood pressure (BP) of patients with hypertension.MethodsThis clinical trial was conducted on 66 military personnel who were definitively diagnosed with hypertension by a physician, and then assigned randomly into two groups as intervention (receiving mobile-based educational app) and control (receiving standard medical management but no app). Before the intervention, BP levels of both groups were measured with a calibrated sphygmomanometer. After 6 weeks, the BPs of both groups were remeasured using the same sphygmomanometer. Thereafter, descriptive and inferential statistics, including paired t-test, Mann-Whitney, Chi-square and Wilcoxon tests, were used. The data obtained were analysed using SPSS-21 software at a significance level of p<0.05.ResultsComparison of the intervention and control groups showed no statistically significant difference between the groups in systolic BP (p=0.479) and diastolic BP (p=0.851) in the pre-intervention phase, but after the intervention, systolic and diastolic BP levels were significantly lower in the intervention group than in the control group (p=0.0001).ConclusionThe results suggested that the mobile-based educational app had a significant effect on reducing BP in patients with hypertension. Therefore, using this app is recommended for those military personnel with hypertension.

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Assessment of Regulatory T Cells in Childhood Immune Thrombocytopenic Purpura

ISRN Hematology ◽

10.1155/2013/143687 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Karina L. M. Mazzucco ◽

Lauro M. Junior ◽

Natália E. Lemos ◽

Andréa Wieck ◽

Annelise Pezzi ◽

...

Keyword(s):

T Cells ◽

Case Control Study ◽

Treg Cells ◽

Healthy Controls ◽

Newly Diagnosed ◽

Control Groups ◽

Platelet Counts ◽

Significant Difference ◽

And Control ◽

Control Study

This study had the objective to assess the frequency of Tregs in children newly diagnosed with ITP and ascertain whether an association exists between Tregs and platelet counts, by means of a comparison with healthy controls. This case-control study included 19 patients newly diagnosed with ITP—whose blood samples were collected at four points in time: before any therapy and 1, 3, and 6 months after diagnosis—and 19 healthy controls. Tregs (CD4+ CD25+Foxp3 T cells) were evaluated by flow cytometry. There was a statistically significant difference in platelet count between the case and control groups. There were no significant differences in Treg counts between cases and controls at any point during the course of the study and no difference in Treg counts between the chronic and nonchronic groups and no significant correlation between Tregs and platelet counts in the case and control groups. The findings of this study did not show any statistically significant correlation between Tregs and number of platelets in the case and control groups. Treg cells did not play a role in the regulation of autoimmunity in children with ITP.

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Association Between Serum Cadmium and Arsenic Levels with Bladder Cancer: A Case-control Study

International Journal of Cancer Management ◽

10.5812/ijcm.106642 ◽

2021 ◽

Vol 14 (7) ◽

Author(s):

Vahid Moazed ◽

Elham Jafari ◽

Mohammad Reza Ebadzadeh ◽

Amin Pourzare ◽

Hamid Reza Gharehchahi ◽

...

Keyword(s):

Bladder Cancer ◽

Regression Models ◽

Case Control Study ◽

Case Control ◽

P Value ◽

Control Groups ◽

Significant Difference ◽

The Mean ◽

And Control ◽

Control Study

Background: Bladder cancer is the second most common cancer of the genitourinary system and the eighth cause of cancer death. In addition to known risk factors such as smoking and urinary stones, trace elements are also effective in causing bladder cancer and other cancers. Objectives: This study was conducted to determine the association between bladder cancer and the carcinogens cadmium and arsenic. Methods: This case-control study was conducted on 40 patients with bladder cancer admitted to Shahid Bahonar Hospital and a control group of 40 healthy individuals in Kerman, Iran, in 2018. The serum levels of arsenic and cadmium were measured by atomic absorptiometry. The paired t-test and chi-square tests were employed to assess the difference between cases and controls groups. An unadjusted and 2 multivariable conditional regression models were separately adjusted on sex, family cancer history, residence, occupation, and smoking and were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) to assess the association between arsenic and cadmium levels and bladder cancer. The statistical software SPSS version 26 and R software version 3.6.3 were used to perform the statistical analyses. Results: The mean cadmium level was 2.99 ± 1.45 and 2.59 ± 0.46 in the case and control groups, respectively, with no statistically significant difference between the groups (P = 0.100). The mean arsenic level was 2.12 ± 1.04 and 1.43 ± 0.73 in the case and control groups, respectively, demonstrating a statistically significant difference between the groups (P = 0.001). Unadjusted and adjusted conditional logistic regression models indicated significant association between arsenic levels and bladder cancer (unadjusted: odds ratio (OR) (95% CI): 0.66 (0.46 - 0.94), P-value = 0.022; adjusted: OR (95% CI): 0.64 (0.44 - 0.92), P-value = 0.018). Conclusions: Overall, cadmium and arsenic levels are higher in patients with bladder cancer, with a statistically significant difference for arsenic. However, these elements are not interrelated and are not related to other factors.

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