scholarly journals Rate of Anti-NMDA Receptor Encephalitis in Ovarian Teratomas

2021 ◽  
Author(s):  
Jennifer H. Li ◽  
Sarah S. Milla ◽  
Grace Y. Gombolay
Keyword(s):  
Cohort Study ◽  
Nmda Receptor ◽  
Retrospective Cohort ◽  
Multiple Linear Regression Model ◽  
Ovarian Teratoma ◽  
Histopathological Diagnosis ◽  
Nmda Receptor Encephalitis ◽  
Aspartate Receptor ◽  
Receptor Antibodies ◽  
Ovarian Teratomas

Abstract Background The rate of anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) in ovarian teratomas is unknown. We aim to identify the prevalence of NMDARE as well as volumetric and histopathologic characteristics of ovarian teratomas in patients with versus without. Methods We performed a retrospective cohort study to identify patients with confirmed ovarian teratomas and the characteristics of teratomas in NMDARE compared with non-NMDARE patients. Patients aged between 0 and 21 years with confirmed histopathological diagnosis of ovarian teratoma after resection were included. The rate of NMDARE in ovarian teratomas was identified. Moreover, volumes of ovarian teratomas and the frequency of neuronal glial elements on histopathology in NMDARE versus non-NMDARE patients were assessed. Results Five out of one-hundred-and-sixty-three (3.07%) patients with histopathology confirmed ovarian teratomas were diagnosed with NMDARE. Age was not different between the NMDARE (mean: 13.8 years, standard deviation: 3.9) and non-NMDARE groups (median: 14, interquartile range [IQR]: 5). Teratoma volumes from NMDARE patients were smaller than those of non-NMDARE patients (median 28.3 cm3 with IQR of 431.2 and median 182.8 with IQR of 635.0, respectively). Both age and NMDARE diagnosis were statistically significant variables in the analysis of variance on a multiple linear regression model. Age (p = 0.013) had a positive correlation with teratoma size, whereas presence of NMDARE had a negative correlation (p = 0.008). Conclusion The rate of NMDARE in ovarian teratomas is low and NMDARE patients have smaller teratomas than non-NMDARE. Further studies are needed to understand the timing of anti-NMDA receptor antibodies in teratomas and the development of NMDARE.

scholarly journals A Case of Anti-NMDA Receptor Encephalitis with a History of Removal of Ovarian Teratoma

2013 ◽  
Vol 102 (11) ◽  
pp. 2972-2975
Author(s):  
Miho Kawabe ◽  
Yukifusa Igeta ◽  
Taro Bannai ◽  
Hideyuki Matsumoto ◽  
Hideji Hashida
Keyword(s):  
Nmda Receptor ◽  
Ovarian Teratoma ◽  
Nmda Receptor Encephalitis ◽  
History Of

Anti-N-methyl-D-aspartate receptor encephalitis and ovarian teratomas: is there any association?

2020 ◽  
Vol 19 (5) ◽  
pp. 124-131
Author(s):  
N.M. Podzolkova ◽  
◽  
V.V. Korennaya ◽  
O.S. Levin ◽  
E.E. Vasenina ◽  
...  
Keyword(s):  
Pathological Condition ◽  
Rare Complication ◽  
Autoimmune Encephalitis ◽  
Neurological Deficits ◽  
Ovarian Teratoma ◽  
Aspartate Receptor ◽  
Nmdar Encephalitis ◽  
Life Threatening ◽  
Causal Treatment ◽  
Ovarian Teratomas

This article aims to explore the problem of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis and also describes our own experience in treating anti-NMDAR encephalitis in patients with ovarian teratomas. This pathological condition is a rare complication of cancer. Practicing gynecologists are often unfamiliar with it, although its consequences can be life-threatening. Early diagnosis and causal treatment, particularly teratoma removal, are critical for the outcome and can prevent death or the development of neurological deficits in patients. Key words: anti-NMDAR, autoimmune encephalitis, ovarian cysts, complications, ovarian teratoma, encephalitis, encephalitis in women

Anti-NMDA receptor encephalitis: two case reports associated with ovarian teratoma and a literature review

2019 ◽  
Vol 39 (6) ◽  
pp. 864-865
Author(s):  
Javier Sancho-Saúco ◽  
Virginia Corraliza-Galán ◽  
Jesus Lázaro-Carrasco de la Fuente ◽  
Concepcion Sánchez-Martínez ◽  
Irene Pelayo-Delgado ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Literature Review ◽  
Case Reports ◽  
Ovarian Teratoma ◽  
Nmda Receptor Encephalitis

scholarly journals The Association of Ovarian Teratoma and Anti-N-Methyl-D-Aspartate Receptor Encephalitis: An Updated Integrative Review

2021 ◽  
Vol 22 (20) ◽  
pp. 10911
Author(s):  
Cheng-Yang Wu ◽  
Jiann-Der Wu ◽  
Chien-Chin Chen
Keyword(s):  
Cerebral Spinal Fluid ◽  
Treatment Strategies ◽  
Paraneoplastic Neurological Syndrome ◽  
Cell Tumor ◽  
Ovarian Teratoma ◽  
Cell Populations ◽  
Aspartate Receptor ◽  
Nmdar Encephalitis ◽  
Somatic Transformation ◽  
Ovarian Teratomas

Ovarian teratomas are by far the most common ovarian germ cell tumor. Most teratomas are benign unless a somatic transformation occurs. The designation of teratoma refers to a neoplasm that differentiates toward somatic-type cell populations. Recent research shows a striking association between ovarian teratomas and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, a rare and understudied paraneoplastic neurological syndrome (PNS). Among teratomas, mature teratomas are thought to have a greater relevance with those neurological impairments. PNS is described as a neurologic deficit triggered by an underlying remote tumor, whereas anti-NMDAR encephalitis is characterized by a complex neuropsychiatric syndrome and the presence of autoantibodies in cerebral spinal fluid against the GluN1 subunit of the NMDAR. This review aims to summarize recent reports on the association between anti-NMDAR encephalitis and ovarian teratoma. In particular, the molecular pathway of pathogenesis and the updated mechanism and disease models would be discussed. We hope to provide an in-depth review of this issue and, therefore, to better understand its epidemiology, diagnostic approach, and treatment strategies.

scholarly journals The Association Between Age and Prognosis in Patients Under 45 Years of Age With Anti-NMDA Receptor Encephalitis

2020 ◽  
Vol 11 ◽  
Author(s):  
Yueqian Sun ◽  
Guoping Ren ◽  
Jiechuan Ren ◽  
Wei Shan ◽  
Xiong Han ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Retrospective Study ◽  
Nmda Receptor ◽  
Confidence Interval ◽  
Modified Rankin Scale ◽  
Odds Ratios ◽  
Nmda Receptor Encephalitis ◽  
Aspartate Receptor ◽  
Multivariable Logistic Regression ◽  
Neurological Prognosis

This study aims to evaluate the association between age and prognosis in patients with anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) under the age of 45 years. A retrospective study was conducted in patients younger than 45 years diagnosed as anti-NMDARE in four hospitals in China. Age at admission was divided into four categories: <15, 15–24, 25–34, 35–45 years. Neurological prognosis was evaluated using modified Rankin Scale. Adjusted multivariable logistic regression was used to analyze the association. The multivariable-adjusted odds ratios (95% confidence interval) of prognosis in anti-NMDARE across the categories of age were as follows: in males, 1.00 (reference), 4.76 (0.39–58.76), 13.50 (0.79–230.40), and 8.81 (0.36–218.39) (P for trend = 0.171); in females, 1.00 (reference), 7.27 (0.36–146.19), 20.08 (1.09–370.39), and 54.41 (1.60–1,849.10) (P for trend = 0.01). We concluded that the increasing age was associated with a poorer prognosis of anti-NMDARE in females but not males.

scholarly journals NATURAL PRODUCTS IN TREATMENT OF ENCEPHALITIS: A REVIEW

2021 ◽  
Vol 21 (no 1) ◽  
Author(s):  
Danishpreet Kaur Takhar ◽  
Mukta Gupta
Keyword(s):  
Natural Products ◽  
Nmda Receptor ◽  
Plasma Exchange ◽  
Intravenous Immunoglobulin ◽  
Psychotic Disorders ◽  
Treatment Options ◽  
Therapeutic Approaches ◽  
Nmda Receptor Encephalitis ◽  
Aspartate Receptor

Brain on fire, an unusual phrase used for the deadliest autoimmune ailment, called anti-NMDA (N-methyl-D-aspartate) receptor encephalitis, characterizing extreme psychiatric and neurotic signs. Though being the deadliest one, still it can be treated with the help of various therapeutic approaches such as Corticosteroids, Intravenous immunoglobulin (IVIG) and plasmapheresis or plasma exchange. Although the prevalence of encephalitis can be observed in both the sexes, however the majority of ailment (95%) is seen in women with teratoma ovaries or different neoplasms. Recognition of nti-NMDA receptor encephalitis could be very essential to avoid any misconception regarding incorrect interpretation of various psychotic disorders. However, various treatment options are available still further investigation should be required to carried out to find out other clinically beneficial drugs.

scholarly journals Psychotic Symptoms Related Anti NMDA Receptor in Ovarian Teratoma

2020 ◽  
Vol 1 (2) ◽  
pp. 1-8
Author(s):  
Ester G Panserga ◽  
Patricia Wulandari ◽  
Rachmat Hidayat
Keyword(s):  
Nmda Receptor ◽  
Neuropsychiatric Symptoms ◽  
Ovarian Teratoma ◽  
Psychotic Symptoms ◽  
Cellular Mechanisms ◽  
Delayed Treatment ◽  
Neurological Outcomes ◽  
Nmda Receptor Encephalitis ◽  
The Impact

Abstract Psychotic symptoms related ovarian teratoma are uncommon but has been well known in previous medical literature. Psychotic problems experienced by patients are often mistaken for psychological causes without organic causes, because commonly patients do not show symptoms associated with teratomas. Diagnosis of teratoma-related psychotic illnesses is often delayed due to the nature of the symptoms, that is leading to delayed treatment and worsen long-term neurological outcomes. Neuropsychiatric symptoms in teratoma can occur if it contains brain tissue inside and antibody anti-NMDA (N-methyl-D-Aspartate) receptor. The occurrence of psychotic symptoms in ovarian teratomas is based on cellular mechanisms. Antibodies bind to the NMDA receptor, which leads to the internalization of the cell surface and the relative state of the NMDA receptor hypofunction. While the impact of specific regions and circuit circuits of anti-NMDA receptor antibodies remains to be explored, the mechanism of anti-NMDA receptor encephalitis strengthens the hypothesis that NMDA receptor hypofunction may have a role in schizophrenia and psychosis.

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