Laterotrusion (Side to Side) and Protrusion/Retraction Difficulty of Tongue in Two Children with Wilson's Disease

2021 ◽  
Author(s):  
Roshan Koul ◽  
Arjun Maria ◽  
Seema Alam
Keyword(s):  
Wilson’S Disease ◽  
Neuromuscular Diseases ◽  
Wilson's Disease ◽  
Second Child ◽  
First Child ◽  
Tongue Movements ◽  
Neurological Features ◽  
Extrapyramidal Features ◽  
Treatable Condition ◽  
Rule Out

AbstractInvolvement of tongue is uncommon in Wilson's disease (WD) in early stages. This is usually seen late when the patient has an established neurological WD associated with dyskinesia, dystonia, and tremors. In this article, we presented two children with tongue involvement in which there were slow laterotrusion (side to side) and protrusion and retraction movements. In the first child this was the early and only manifestation without any other neurological features while in the second child this was seen in a previously diagnosed WD. Slow tongue movements in any child with or without extrapyramidal features should be investigated to rule out a treatable condition like WD. Tongue involvement is common in children with different neurological/neuromuscular diseases, drugs, and other unknown conditions.

scholarly journals Isolated lingual involvement in Wilson’s disease

2015 ◽  
Vol 6 (03) ◽  
pp. 431-433 ◽  
Author(s):  
Neera Choudhary ◽  
Laxmikant Joshi ◽  
Ashish Duggal ◽  
Vinod Puri ◽  
Geeta Anjum Khwaja
Keyword(s):  
Motor Neuron ◽  
Clinical Diagnosis ◽  
Neurological Disorders ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Lower Motor Neuron ◽  
Clinical Variability ◽  
Tongue Movements

ABSTRACTLingual involvement can occur in a variety of neurological disorders including pyramidal, extrapyramidal and lower motor neuron disorders. It can be seen in the form of tremor, bradykinesia, dystonia, atrophy and weakness of tongue movements and can clinically present as difficulty in swallowing and dysarthria which can be a source of great discomfort to the patient. We describe a patient who presented with isolated lingual involvement and was diagnosed to have Wilsons’s disease. This case emphasizes the clinical variability in presentation of Wilson’s disease and importance of early clinical diagnosis.

Mania as a presenting symptom of Wilson's disease

2006 ◽  
Vol 18 (1) ◽  
pp. 47-49 ◽  
Author(s):  
Prabhat Kumar Chand ◽  
Pratima Murthy
Keyword(s):  
Wilson’S Disease ◽  
Psychiatric Symptoms ◽  
Lithium Carbonate ◽  
Wilson's Disease ◽  
Extrapyramidal Symptoms ◽  
Psychiatric Clinic ◽  
Initial Examination ◽  
High Propensity ◽  
Neuroleptic Withdrawal ◽  
Rule Out

Objective:Wilson's disease commonly presents with neurological or hepatic manifestations. When it presents with only psychiatric symptoms, or with extrapyramidal symptoms secondary to neuroleptic exposure, the diagnosis of underlying Wilson's disease may be missed.Methods:An 18-year-old boy presented to the psychiatric clinic with a manic syndrome and high propensity for extrapyramidal symptoms to neuroleptic. Initial examination revealed splenomegaly and pancytopenia. Subsequent detection of Kayser–Fleischer ring and typical biochemical findings confirmed the diagnosis of Wilson's disease.Results:While the psychiatric symptoms came under control with lithium carbonate, extrapyramidal symptoms continue to persist even after neuroleptic withdrawal. Pancytopenia thought to be due to hypersplenism persists, and patient has developed features of liver cirrhosis. Treatment with zinc and folic acid has been started, and the patient is under evaluation for treatment with penicillamine.Conclusion:The psychiatrist needs to recognize that Wilson's disease can uncommonly present with isolated psychiatric symptoms, including mania. Early and severe extrapyramidal symptoms secondary to neuroleptic exposure in an adolescent age group warrants a detailed evaluation to rule out underlying neuropsychiatric conditions.

scholarly journals ATYPICAL MANIFESTATIONS OF ACUTE HEPATITIS IN ADOLESCENT AGE GROUP: MANDATORY TO RULE OUT WILSON’S DISEASE

2020 ◽  
Vol 06 (05) ◽  
pp. 227-228
Author(s):  
Fehmida Najmuddin ◽  
Keya Rani Lahiri ◽  
Anand Sude ◽  
Anshita Bansal ◽  
Manisha Reddy ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Age Group ◽  
Atypical Manifestations ◽  
Rule Out

scholarly journals Catatonic Disorder due to Wilson’s disease - A rare presentation

2015 ◽  
pp. 17-20
Author(s):  
Tanushree Bhattacharya ◽  
Asish Debnath ◽  
Sharmila Sarkar
Keyword(s):  
Wilson Disease ◽  
Autosomal Recessive ◽  
Wilson’S Disease ◽  
Autosomal Recessive Disorder ◽  
Wilson's Disease ◽  
The Body ◽  
Rare Presentation ◽  
Neurological Features ◽  
Copper Chelators ◽  
Psychiatric Manifestations

Wilson disease (WD) is a relatively rare autosomal recessive disorder caused by the mutation of ATP7B gene, resulting in impaired transportation of copper in the body which is then deposited in various organs such as liver, brain and kidney. Catatonia at first presentation in WD has rarely been reported. Here we report a case of a 14 year old boy who presented with catatonia among other neuropsychiatric features and who was later diagnosed with Wilson's disease. He responded well to treatment with Copper chelators, olanzapine and lorazepam. Though uncommon, a diagnosis of Wilson's disease should be considered in the evaluation of adolescents and young adults presenting with psychiatric manifestations &/or neurological features.

scholarly journals Generalized hyperpigmentation in Wilson’s disease: An unusual association

2013 ◽  
Vol 04 (01) ◽  
pp. 70-72 ◽  
Author(s):  
Madhumita Nandi ◽  
Sumantra Sarkar ◽  
Rakesh Mondal
Keyword(s):  
Autosomal Recessive ◽  
Wilson’S Disease ◽  
Copper Metabolism ◽  
Autosomal Recessive Disorder ◽  
Wilson's Disease ◽  
Unusual Association ◽  
Diagnostic Difficulties ◽  
The Central Nervous System ◽  
Neurological Features ◽  
Atypical Presentations

ABSTRACTWilson’s disease, an autosomal recessive disorder of copper metabolism, most commonly presents either with hepatic or neurological features. But, it may sometimes have certain atypical presentations posing diagnostic difficulties. We report here a case of Wilson’s disease presenting with generalized hyperpigmentation of skin who also developed neurological manifestations subsequently. We aim to highlight the importance of keeping Wilson’s disease as one of the differentials in patients who present with hyperpigmentation and neurological symptoms compatible with copper deposits in the central nervous system and proceed for investigations accordingly.

Neurological features and outcomes of Wilson’s disease: a single-center experience

2021 ◽  
Author(s):  
Bedia Samanci ◽  
Erdi Sahin ◽  
Basar Bilgic ◽  
Zeynep Tufekcioglu ◽  
Hakan Gurvit ◽  
...  
Keyword(s):  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Single Center ◽  
Single Center Experience ◽  
Neurological Features

Massive hepatic haemosiderosis in Wilson's disease

2000 ◽  
Vol 37 (2) ◽  
pp. 187-189 ◽  
Author(s):  
P Luca ◽  
L Demelia ◽  
S Lecca ◽  
R Ambu ◽  
G Faa
Keyword(s):  
Wilson’S Disease ◽  
Wilson's Disease
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