Severe and Life-Threatening Adverse Reactions to Psychotropic Drugs

1988 ◽  
Vol 21 (06) ◽  
pp. 290-292 ◽  
Author(s):  
C. Spieß-Kiefer ◽  
R. Grohmann ◽  
L. Schmidt ◽  
E. Rüther
Keyword(s):  
Psychotropic Drugs ◽  
Adverse Reactions ◽  
Life Threatening

„Atypical Dyskinesia“ – Uncommon Adverse Reactions due to Psychotropic Drugs

2005 ◽  
Vol 38 (01) ◽  
Author(s):  
S Stübner ◽  
R Grohmann ◽  
R Engel ◽  
HJ Möller ◽  
H Hippius ◽  
...  
Keyword(s):  
Psychotropic Drugs ◽  
Adverse Reactions

scholarly journals Case Series of Three Patients with Rifampicin-Induced Thrombocytopenia

2020 ◽  
Author(s):  
Chandramouli M.T
Keyword(s):  
Pulmonary Tuberculosis ◽  
Adverse Reactions ◽  
Rare Complication ◽  
Case Series ◽  
Tuberculosis Treatment ◽  
Effective Drug ◽  
Antitubercular Drugs ◽  
Short Course ◽  
Life Threatening

AbstractLife-threatening adverse reactions of antitubercular drugs are uncommon; however, thrombocytopenia is one such rare complication encountered with rifampicin, isoniazid, ethambutol, and pyrazinamide. Rifampicin is the most effective drug and its use in the tuberculosis treatment led to the emergence of modern and effective short-course regimens. I am reporting case series of three patients with pulmonary tuberculosis presented with rifampicin-induced thrombocytopenia.

scholarly journals Lidocaine: A Local Anesthetic, Its Adverse Effects and Management

Medicina ◽  
2021 ◽  
Vol 57 (8) ◽  
pp. 782
Author(s):  
Entaz Bahar ◽  
Hyonok Yoon
Keyword(s):  
Adverse Effects ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Adverse Reactions ◽  
Rapid Diagnosis ◽  
Diagnosis And Treatment ◽  
Allergic Reactions ◽  
Life Threatening

The most widely used medications in dentistry are local anesthetics (LA), especially lidocaine, and the number of recorded adverse allergic responses, particularly of hazardous responses, is quite low. However, allergic reactions can range from moderate to life-threatening, requiring rapid diagnosis and treatment. This article serves as a review to provide information on LA, their adverse reactions, causes, and management.

scholarly journals Fatal case of toxic epidermal necrolysis induced by ciproflfl oxacin in a child

2021 ◽  
Vol 12 (Supp 1) ◽  
pp. 26-29
Author(s):  
Thomas Schiestel
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Adverse Reactions ◽  
Pediatric Population ◽  
Fatal Case ◽  
Stevens Johnson Syndrome ◽  
Delayed Treatment ◽  
Drug Eruptions ◽  
Johnson Syndrome ◽  
Life Threatening

Bullous drug eruptions such as Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but known adverse reactions of fluoroquinolones. Although uncommon, TEN can be life-threatening for the patient, especially in the context of delayed treatment and in fragile patients such as the pediatric population. In the present case, TEN occurred in a 13-year-old girl with no medical history following initiation of ciprofloxacin treatment for an inguinal cyst. We hope that the case report will make interrogate the practices concerning the use of antibiotics, in particular fluoroquinolones in the context of an use not prescribed by the Marketing Authorization of the drug in children.

Advances in Management of Food Allergy in Children

2020 ◽  
Vol 16 (2) ◽  
pp. 123-128
Author(s):  
Fernanda Chiera ◽  
Lucia Caminiti ◽  
Giuseppe Crisafulli ◽  
Giovanni Battista Pajno
Keyword(s):  
Food Allergy ◽  
Adverse Reactions ◽  
Medical Condition ◽  
Oral Immunotherapy ◽  
Health Concern ◽  
Therapeutic Approaches ◽  
Herbal Supplements ◽  
Significant Public Health Concern ◽  
Significant Public Health ◽  
Life Threatening

Food allergy is a potentially life-threatening medical condition and a significant public health concern worldwide. The current management consists of strict avoidance of the culprit food and treating any adverse reactions from unintended food ingestion. The increasing prevalence of food allergy encouraged research and clinical trials in the field of specific allergen immunotherapy (AIT) which represents an appealing approach, especially in pediatric age. AIT consists of the gradual administration of growing amounts of the offending allergen in order to induce food desensitization, which is an increase in the threshold for reactivity while continuing on regular exposure to the allergen. AIT can be administered through oral, sublingual, epicutaneous, and subcutaneous routes. Reports on oral immunotherapy (OIT) thus far have been more extensive. The desirable goal is to achieve "post desensitization effectiveness", that is the ability to introduce food without reaction even after a period of discontinuation of the offending food. Other therapeutic approaches are being studied alongside immunotherapy such as modified proteins, probiotics, Chinese herbal supplements, biologic therapies, and DNA vaccines.

Adverse reactions to medication

2019 ◽  
pp. 103-114
Author(s):  
Tomasz Bajorek ◽  
Jonathan Hafferty
Keyword(s):  
Adverse Effect ◽  
Adverse Effects ◽  
Adverse Reactions ◽  
Bleeding Risk ◽  
Inpatient Setting ◽  
Extrapyramidal Side Effects ◽  
Inpatient Psychiatry ◽  
Drug Induced ◽  
Threatening Condition ◽  
Life Threatening

Adverse reactions to medication represent a major issue in inpatient psychiatry. This chapter systematically explores the most relevant, concerning, and problematic adverse effects routinely encountered in an inpatient setting. It describes the typical presentation, pathophysiology, incidence, and practical management of these problems. Extrapyramidal side effects including acute dystonia, drug-induced parkinsonism, akathisia, and tardive dyskinesia are considered before the chapter explores the rare but potentially life-threatening condition of neuroleptic malignant syndrome. Other adverse effects common to antipsychotics that are described include hyperprolactinaemia and psychotropic-induced arrhythmias including QTc prolongation. Sexual dysfunction is an under-recognized and undertreated adverse effect common to several classes of psychotropic medication and is also considered. Focusing on antidepressants, the chapter reviews the frequently encountered issue of hyponatraemia as well as serotonin syndrome and selective serotonin reuptake inhibitor-induced bleeding risk. Finally, the chapter addresses perinatal considerations for psychotropic drugs.

Cutaneous Adverse Reactions to Psychotropic Drugs

2009 ◽  
Vol 70 (9) ◽  
pp. 1258-1265 ◽  
Author(s):  
Christian Lange-Asschenfeldt ◽  
Renate Grohmann ◽  
Bernhard Lange-Asschenfeldt ◽  
Rolf R. Engel ◽  
Eckart Rüther ◽  
...  
Keyword(s):  
Psychotropic Drugs ◽  
Adverse Reactions ◽  
Cutaneous Adverse Reactions

scholarly journals Tetracycline Allergy

Pharmacy ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 104 ◽  
Author(s):  
Leslie A. Hamilton ◽  
Anthony J. Guarascio
Keyword(s):  
Adverse Reaction ◽  
Adverse Reactions ◽  
Allergic Reactions ◽  
Hypersensitivity Reactions ◽  
Serious Adverse Events ◽  
Tetracycline Antibiotics ◽  
Reaction Type ◽  
Pubmed Search ◽  
Life Threatening ◽  
Selection Of

Despite the widespread use of tetracycline antibiotics since the late 1940s, tetracycline hypersensitivity reactions have rarely been described in the literature. A comprehensive PubMed search was performed, including allergic and serious adverse reactions attributed to the tetracyclines class of antibiotics. Of the evaluated tetracycline analogs, minocycline was attributed to the greatest overall number and severity of serious adverse events reported in the literature, with notable reactions primarily reported as respiratory and dermatologic in nature. Reactions to tetracycline have also been well described in the literature, and although dermatologic reactions are typically less severe in comparison with minocycline and doxycycline, various reports of anaphylactic reactions exist. Although doxycycline has been noted to have had the fewest reports of severe allergic reactions, rare descriptions of life-threatening reactions are still reported in the literature. Allergic reactions regarding tetracyclines are rare; however, adverse reaction type, severity, and frequency among different tetracycline analogs is somewhat variable. A consideration of hypersensitivity and adverse reaction incidence should be performed prior to the selection of individual tetracycline entities.

scholarly journals P13 Serious adverse reactions and off label and unlicensed drug use in children – decade of pharmacovigilance study in Serbia

2019 ◽  
Vol 104 (6) ◽  
pp. e22.2-e22
Author(s):  
M Bajcetic ◽  
J Joksimovic
Keyword(s):  
Drug Use ◽  
Adverse Reactions ◽  
Drug Formulation ◽  
System Organ Class ◽  
List Type ◽  
Age Group ◽  
Sources Of Information ◽  
Antimicrobial Drugs ◽  
Off Label ◽  
Life Threatening

BackgroundOff label (OL) and unlicensed (UL) drug use in children is a widespread global problem. Previous study showed that only 66% of all available drugs for children is with licence in Serbia.1 Data on safety of medicines in children remain lacking, so the key intervention for the effective use of medicine is safety monitoring. Therefore, the aim of this study is to evaluate safety implication of OL and UL drug use in children up to 12 years old.MethodWe conducted a retrospective study based on reports of suspected adverse reactions (ADRs) collected from 2008. to 2018. by Medicines and Medical Devices Agency of Serbia, using the Medical Dictionary for Regulatory Activities and organized by System Organ Class. Sources of information about medicines including vaccines (license, drug formulation, etc.) are the Summary of Product Characteristics and Serbia´s official drug registry.ResultsWithin 10 years, we observed 1595 ADRs. Vaccines, antineoplastic and antimicrobial drugs were the most frequently pharmacotherapeutic subgroups involved. Out of total number of observed ADRs, 433 (28%) were serious; 189 of them led to hospitalization, 31 to life threatening conditions and 7 were fatal. More than a half (63%) of serious ADRs were detected in children for the age group of 28 days - 23 months, followed by the age group of 2 to 11 years (34%) and finally by age group of 0 to 27 days (3%). Serious ADRs were detected in boys (55%) as well as in girls (45%). Out of total number of registered only 3% (46) of ADRs were associated with off-label use; 18 of them were serious, 7 led to life threatening conditions and 3 were fatal.ConclusionThis research provided new insight on the factors such as OL and UL use, that might increase the risk of serious ADRs in children.ReferencesBo&zbreve;ić B, Stupar S, Stupar D, Babić U, Bajčetić M. Availability of pediatric-evaluated formulations in Serbia. Indian J Pharmacol 2017 Mar-Apr;49(2):189–193Disclosure(s)Nothing to disclose

Efficacy and Clinical Tolerance of a New Combination of Trimethoprim with Sulphonamide

1986 ◽  
Vol 14 (5) ◽  
pp. 236-241 ◽  
Author(s):  
Fabio Celotti ◽  
Franklin Nüdemberg ◽  
Osvaldo Magni ◽  
Francesca Piaia
Keyword(s):  
Clinical Trials ◽  
Side Effects ◽  
General Practitioners ◽  
Antimicrobial Chemotherapy ◽  
Adverse Reactions ◽  
New Combination ◽  
Combination Product ◽  
Cure Rate ◽  
Post Marketing ◽  
Life Threatening

To obtain a direct clinical evaluation of a new sulpha-trimethoprim combination product (Kelfiprim®) from general practitioners or specialist practitioners, an extensive post-marketing survey has been organized in Brazil involving 1,177 doctors and 5,885 patients. These experienced different infections susceptible to oral antimicrobial chemotherapy with a sulpha-trimethoprim combination. The results indicated that the product was very effective (91.2% cure rate) and well tolerated (4% incidence of side-effects). Side-effects were usually mild and transient. No life-threatening adverse reactions were observed. The results obtained support those already published in clinical trials involving 1,119 patients.

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