Synthesis of Chitosan graft amoxilline as drug natural polymer for medical use

Cancer is assemblage diseases involving abnormal cell growth amid the potential of spread to other parts of the body due to tobacco use are the cause of about of cancer deaths. Another 10% is due to obesity, poor diet & drinking alcohol. In 2012 about 14.1 million new cases of cancer occurred globally. In females, the most common type is breast cancer. Cisplatin also known as cytophosphane is a nitrogen mustard alkylating agent from the oxazophosphinans groups were used to treat cancers & autoimmune disorders. Based on the above reasons I will fix the aim Preparation characterization of Cisplatin- nano particles & its anticancer activity. Solid tumor volume examination report showed that the assessment of different day indication 15,20,25 & 30th variations of different groups of tumor volumes were decreased CPG Nanoparticles (100 mg/kg)+ DAL(15th day 4.97±0.24↓), (20th day 0.6±0.13↓), (25th day 1.35±0.30↓) & (30th day 1.89±0.13↓).

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Plantago Ovata and Locust Bean Gum as a Natural Polymer in Hydrodynamically Balanced Systems: A Review

Journal of Biomedical and Allied Research ◽

10.37191/mapsci-2582-4937-2(1)-015 ◽

2020 ◽

Author(s):

Ghildiyal s

Keyword(s):

Drug Delivery ◽

Locust Bean Gum ◽

Main Role ◽

Natural Polymer ◽

Release Formulation ◽

Sustained Drug Delivery ◽

Modern Drug ◽

Buccal Drug Delivery ◽

Locust Bean ◽

Ceratonia Siliqua L

Hydrodynamically Balanced systems have wide development as they have achieved the parameters of modern drug delivery system, it is a type of system which owes very tremendous and curative benefits for the delivery of oral controlled release dosage forms and have wide properties in many aspects such as its main role is to maintain the effective concentration in the system for longer period of time. To reduce the gastric mucosal irritation due to the presence of synthetic polymers, being a natural polymer incorporation of Plantago ovate (Psyllium Husk) could ease out the mucosal irritation in the gastric region. Due to its properties such as a rate-controlling polymer possessing a very good quality of swelling and good gelling nature, and also incorporated as a matrix-forming agent basically in the modified release formulation. Locust bean gum can be used as sustained-release carriers and release modifiers for the delivery of drugs. It is a neutral plant galactomannan extracted from the seeds (kernels) of the carob tree Ceratonia siliqua L fabaceae. Nowadays it is focussing polymer and a lot of researchers are focussing on exploring the potential in topical drug delivery, colonic drug delivery, oral sustained drug delivery, ocular drug delivery, buccal drug delivery.

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Natural polymer-based hydrogels as prospective tissue equivalent materials for radiation therapy and dosimetry

Physical and Engineering Sciences in Medicine ◽

10.1007/s13246-021-01047-6 ◽

2021 ◽

Author(s):

Srilakshmi Prabhu ◽

Dhanya Y. Bharadwaj ◽

Rachaita Podder ◽

S. G. Bubbly ◽

S. B. Gudennavar

Keyword(s):

Radiation Therapy ◽

Natural Polymer ◽

Tissue Equivalent

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Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

Nanomaterials ◽

10.3390/nano11010021 ◽

2020 ◽

Vol 11 (1) ◽

pp. 21

Author(s):

Mina Keshvardoostchokami ◽

Sara Seidelin Majidi ◽

Peipei Huo ◽

Rajan Ramachandran ◽

Menglin Chen ◽

...

Keyword(s):

Extracellular Matrix ◽

Polymer Composite ◽

Electrospun Nanofibers ◽

Synthetic Polymer ◽

Inorganic Materials ◽

Host Cells ◽

Natural Polymer ◽

Reinforced Polymers ◽

Nanofibrous Scaffolds ◽

Artificial Extracellular Matrix

Many types of polymer nanofibers have been introduced as artificial extracellular matrices. Their controllable properties, such as wettability, surface charge, transparency, elasticity, porosity and surface to volume proportion, have attracted much attention. Moreover, functionalizing polymers with other bioactive components could enable the engineering of microenvironments to host cells for regenerative medical applications. In the current brief review, we focus on the most recently cited electrospun nanofibrous polymeric scaffolds and divide them into five main categories: natural polymer-natural polymer composite, natural polymer-synthetic polymer composite, synthetic polymer-synthetic polymer composite, crosslinked polymers and reinforced polymers with inorganic materials. Then, we focus on their physiochemical, biological and mechanical features and discussed the capability and efficiency of the nanofibrous scaffolds to function as the extracellular matrix to support cellular function.

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Study of the effect of band gap and photoluminescence on biological properties of polyaniline/CdS QD nanocomposites based on natural polymer

Scientific Reports ◽

10.1038/s41598-020-80038-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Azita Alipour ◽

Moslem Mansour Lakouraj ◽

Hamed Tashakkorian

Keyword(s):

Band Gap ◽

Emission Intensity ◽

Energy Gap ◽

Conductive Polymer ◽

Biological Properties ◽

Synergy Effect ◽

Natural Polymer ◽

Toxicity Effect ◽

Heterogeneous Chemical ◽

Cell Tissue

AbstractIn this work, band gap, photoluminescence and biological properties of new bionanocomposites based on polyaniline (PANi)/hydrolyzed pectin (HPEc)/cadmium sulfide (CdS) QD nanoparticles (NPs) were studied. In order to improve the morphology and properties, CdS NPs were modified with epichlorohydrin to obtain the modified CdS (mCdS). The CdS@HPEc-g-PANi and mCdS@HPEc-g-PANi samples were synthesized via heterogeneous chemical polymerization and characterized by FTIR, 1HNMR, SEM/XRD, EDX/TEM/EDX-mapping and TGA analyses. The objective of this work is the study of physical, optical and cytotoxicity properties of the nanocomposites and comparison between them. The SEM, XRD and TGA images showed that the modification of NPs resulted in homogeneous morphology, increase of crystalline structure and high thermal stability which influenced on physical and biological property. According to UV-DRS analysis, the mCdS@HPEc-g-PANi indicated lower energy gap compared to the CdS@HPEc-g-PANi nancomposite. The presence of conductive polymer and synergy effect between the PANi and CdS caused higher PL intensity in the CdS@HPEc-g-PANi nanocomposite compared to pure CdS. The emission intensity in the mCdS@HPEc-g-PANi nanocomposite was reduced since the organic modifying agent cause reducing emission intensity. The mCdS@HPEc-g-PANi nanocomposite, due to more compatibility of organic agent with cellular walls of biological cells that help to the diffusion of metal CdS NPs into cell tissue indicated more toxicity effect on cell growth.

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