A score predicts failure of reperfusion after fibrinolytic therapy for acute myocardial infarction

2003 ◽  
Vol 145 (3) ◽  
pp. 508-514 ◽  
Author(s):  
John K. French ◽  
Krishnan Ramanathan ◽  
James T. Stewart ◽  
Wanzhen Gao ◽  
Pierre Théroux ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fibrinolytic Therapy

scholarly journals Bleeding complications of intracoronary fibrinolytic therapy in acute myocardial infarction. Assessment of risk in a randomised trial.

Heart ◽  
1985 ◽  
Vol 54 (5) ◽  
pp. 455-459 ◽  
Author(s):  
F W Verheugt ◽  
M J van Eenige ◽  
J C Res ◽  
M L Simoons ◽  
P W Serruys ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Randomised Trial ◽  
Fibrinolytic Therapy ◽  
Bleeding Complications

Cardiac troponin T in diagnosis of acute myocardial infarction

1991 ◽  
Vol 37 (6) ◽  
pp. 845-852 ◽  
Author(s):  
Johannes Mair ◽  
Erika Artner-Dworzak ◽  
Peter Lechleitner ◽  
Jörn Smidt ◽  
Ina Wagner ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Striated Muscle ◽  
Troponin T ◽  
Venous Blood ◽  
Reference Interval ◽  
Laboratory Diagnosis ◽  
Fibrinolytic Therapy ◽  
Tissue Type ◽  
Enzyme Linked Immunosorbent Assay

Abstract Troponin T is a structurally bound protein found in striated muscle cells. We tested concentrations of its cardiac-specific isotype in peripheral venous blood samples serially drawn from 72 patients with confirmed myocardial infarction. Fifty-nine patients received thrombolytic treatment with intravenous streptokinase, urokinase, or recombinant tissue-type plasminogen activator; because of contraindications, the remaining 13 patients did not. Concentrations of troponin T in plasma, measured by an enzyme-linked immunosorbent assay, started increasing within a few hours after the onset of symptoms (median, 4 h; range, 1-10 h). The sensitivity of troponin T for detecting myocardial infarction was 100% from 10 to 120 h after the onset of symptoms; sensitivity on the seventh day after admission was 84%. Concentrations were increased for up to three weeks in some patients with late or high peak values. Successful reperfusion in Q-wave infarction obviously influences the release of troponin T into plasma, with all such cases showing peak values less than or equal to 26 h (median, 14 h) after the onset of symptoms. Troponin T concentrations in these patients returned to within the reference interval more rapidly than in nonreperfused subjects. In the 13 patients without fibrinolytic therapy, troponin T tended to peak approximately 48 h (median) after the onset of chest pain. Troponin T concentrations in patients for whom thrombolysis was unsuccessful resembled those in patients without fibrinolytic therapy. The specificity of the assay was 96% as tested in samples of 96 emergency-room patients. The reference interval (less than 0.5 micrograms/L) was established from samples of 100 healthy blood donors. Troponin T measurements are a specific and sensitive method for the early and late diagnosis of acute myocardial infarction and could, therefore, provide a new criterion in laboratory diagnosis of its occurrence.

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