Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life

Midlife blood pressure is associated with structural brain changes, cognitive decline, and dementia in late life. However, the relationship between early adulthood blood pressure exposure, brain structure and function, and cognitive performance in midlife is not known. A better understanding of these relationships in the preclinical stage may advance our mechanistic understanding of vascular contributions to late-life cognitive decline and dementia and may provide early therapeutic targets. To identify resting-state functional connectivity of executive control networks (ECNs), a group independent components analysis was performed of functional MRI scans of 600 individuals from the Coronary Artery Risk Development in Young Adults longitudinal cohort study, with cumulative systolic blood pressure (cSBP) measured at nine visits over the preceding 30 y. Dual regression analysis investigated performance-related connectivity of ECNs in 578 individuals (mean age 55.5 ± 3.6 y, 323 female, 243 Black) with data from the Stroop color–word task of executive function. Greater connectivity of a left ECN to the bilateral anterior gyrus rectus, right posterior orbitofrontal cortex, and nucleus accumbens was associated with better executive control performance on the Stroop. Mediation analyses showed that while the relationship between cSBP and Stroop performance was mediated by white matter hyperintensities (WMH), resting-state connectivity of the ECN mediated the relationship between WMH and executive function. Increased connectivity of the left ECN to regions involved in reward processing appears to compensate for the deleterious effects of WMH on executive function in individuals across the burden of cumulative systolic blood pressure exposure in midlife.

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Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study

The Journals of Gerontology Series A ◽

10.1093/gerona/glv162 ◽

2015 ◽

Vol 72 (1) ◽

pp. 89-94 ◽

Cited By ~ 15

Author(s):

B. Gwen Windham ◽

Michael E. Griswold ◽

Seth Lirette ◽

Anna Kucharska-Newton ◽

Randi E. Foraker ◽

...

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Functional Status ◽

Late Life ◽

Relationship Of ◽

Aric Study ◽

The Relationship

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Self-Rated Health Status as a Predictor of Executive Function in Older Latinos

Innovation in Aging ◽

10.1093/geroni/igaa057.1063 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 331-332

Author(s):

Jacqueline Guzman ◽

Yuliana Soto ◽

David Marquez ◽

Susan Aguinaga

Keyword(s):

Executive Function ◽

High Risk ◽

Cognitive Decline ◽

Behavioral Interventions ◽

Controlled Trial ◽

Self Rated Health ◽

Excellent Health ◽

Trail Making ◽

Fair Poor ◽

The Relationship

Abstract Latinos have high risk of Alzheimer’s disease and related dementias (ADRD). Self-rated health (SRH) has been used to predict cognitive decline. Early detection of executive function changes may help identify those at higher risk of cognitive decline. The purpose of this study was to examine the relationship between SRH and executive function in Latinos. Latinos (N=333, 84.4% female, Mage= 64.9 ± 7.08) from the BAILA randomized controlled trial self-rated their health as 1) poor/fair, 2) good, and 3) very good/excellent. Executive function was assessed by the Trail-making B, Verbal Fluency, Stroop C & CW, and the Digit Modality tests and stratified by SRH. One-way analysis of variance showed that the effect of SRH was significant for Trails B, F(2,298)=4.01, p=.019 and Stroop CW, F(2,298)=3.07, p=.048. Tukey’s test indicated that participants who rated their health as fair/poor took longer to complete Trails B (M=196.78±83.0 seconds) compared to those who rated their health as good (M=185.25 ± 85.1 seconds) and very good/excellent (M=149.25±95.3 seconds). Stroop CW results demonstrated that those in the fair/poor health category scored lower (M=17.22±6.6) than those in good (M=19.70±8.5 words/minutes) and very good/excellent health categories (M=18.73±8.2 words/minute). In sum, the results suggest SRH is related to executive function such that lower categories of SRH are indicative of poorer executive function. SRH might be used as a proxy for executive function and as a tool that community leaders can use to identify individuals at high risk of ADRD in need of behavioral interventions.

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Lower functional hippocampal redundancy in mild cognitive impairment

Translational Psychiatry ◽

10.1038/s41398-020-01166-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Stephanie Langella ◽

◽

Muhammad Usman Sadiq ◽

Peter J. Mucha ◽

Kelly S. Giovanello ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Decline ◽

Resting State ◽

Memory Performance ◽

Potential Mechanism ◽

Network Efficiency ◽

Cognitively Normal ◽

Normal Individuals ◽

The Relationship

AbstractWith an increasing prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in response to an aging population, it is critical to identify and understand neuroprotective mechanisms against cognitive decline. One potential mechanism is redundancy: the existence of duplicate elements within a system that provide alternative functionality in case of failure. As the hippocampus is one of the earliest sites affected by AD pathology, we hypothesized that functional hippocampal redundancy is protective against cognitive decline. We compared hippocampal functional redundancy derived from resting-state functional MRI networks in cognitively normal older adults, with individuals with early and late MCI, as well as the relationship between redundancy and cognition. Posterior hippocampal redundancy was reduced between cognitively normal and MCI groups, plateauing across early and late MCI. Higher hippocampal redundancy was related to better memory performance only for cognitively normal individuals. Critically, functional hippocampal redundancy did not come at the expense of network efficiency. Our results provide support that hippocampal redundancy protects against cognitive decline in aging.

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O1-03-02: Blood pressure, memory, and executive function changes in late-life

Alzheimer s & Dementia ◽

10.1016/j.jalz.2012.05.215 ◽

2012 ◽

Vol 8 (4S_Part_3) ◽

pp. P88-P88 ◽

Cited By ~ 1

Author(s):

Shahram Oveisgharan ◽

Alina Solomon ◽

Miia Kivipelto ◽

Vladimir Hachinski

Keyword(s):

Blood Pressure ◽

Executive Function ◽

Late Life

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Resting-State Functional Connectivity in Late-Life Depression: Higher Global Connectivity and More Long Distance Connections

Frontiers in Psychiatry ◽

10.3389/fpsyt.2012.00116 ◽

2013 ◽

Vol 3 ◽

Cited By ~ 22

Author(s):

Iwo Jerzy Bohr ◽

Eva Kenny ◽

Andrew Blamire ◽

John T. O’Brien ◽

Alan J. Thomas ◽

...

Keyword(s):

Functional Connectivity ◽

Resting State ◽

Late Life ◽

Late Life Depression ◽

Resting State Functional Connectivity ◽

Long Distance ◽

Global Connectivity

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The Relationship Between Visit-to-Visit Variability in Systolic Blood Pressure and All-Cause Mortality in the General Population

Hypertension ◽

10.1161/hypertensionaha.110.162255 ◽

2011 ◽

Vol 57 (2) ◽

pp. 160-166 ◽

Cited By ~ 307

Author(s):

Paul Muntner ◽

Daichi Shimbo ◽

Marcello Tonelli ◽

Kristi Reynolds ◽

Donna K. Arnett ◽

...

Keyword(s):

Blood Pressure ◽

General Population ◽

Systolic Blood Pressure ◽

All Cause Mortality ◽

The Relationship

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HUBUNGAN INDEKSMASSA TUBUH DAN LINGKAR PINGGANG DENGAN TEKANAN DARAH LAKI-LAKI DEWASA

JURNAL MEDIA KESEHATAN ◽

10.33088/jmk.v9i2.314 ◽

2018 ◽

Vol 9 (2) ◽

pp. 193-199

Author(s):

Tamariani Manullang

Keyword(s):

Blood Pressure ◽

Waist Circumference ◽

Systolic Blood Pressure ◽

Study Design ◽

Computer Software ◽

Adult Males ◽

Cross Sectional ◽

Relationship Of ◽

The Relationship

Prevalence of hypertension in adult males was highest in PuskesmasBasuki Rahmat (16.2%) as many as 648 cases of hypertension patients which hasincreased compared to 2012 by 12% in cases of hypertension totaled 482 patients((Dinkes Kota, 2013). This study aims to determine the relationship of body massindex (BMI) and waist circumference (WC) with systolic blood pressure (BP) in adultmales in Puskesmas Basuki Rahmat Bengkulu City in 2015. The study design wasdescriptive analytic with cross sectional approach. Study location was in PuskesmasBasuki Rahmat City of Bengkulu. Samples were selected using purposive samplingtotalling 68 people. Criterias sample were being adult males who occupied inPuskesmas Basuki Rahmat City of Bengkulu, aged ≥ 18 years, agreed to beinterviewed,and able to communicate actively. Data were obtained include BMI, WCand systolic BP adult males and processed using computer software with pearsoncorrelation analysis.The results showed that there was relationship between BMI andsystolic BP (p = 0.0005; r = 0.395); between WC and systolic BP (p = 0.004 and r =0.347) in adult males. This study concluded that there was relationship between BMIand WC with systolic BP in adult males in Puskesmas Basuki Rahmat Bengkulu Cityin 2015.

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A within-individual investigation on the relationship between day level workaholism and systolic blood pressure

Work & Stress ◽

10.1080/02678373.2021.1976883 ◽

2021 ◽

pp. 1-18

Author(s):

Cristian Balducci ◽

Paola Spagnoli ◽

Stefano Toderi ◽

Malissa A. Clark

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

The Relationship

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Abstract 17973: Biomass Fuel Use is Associated With Elevated Blood Pressure and Hypertension Status in Puno, Peru

Circulation ◽

10.1161/circ.130.suppl_2.17973 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Melissa S Burroughs Pena ◽

Karina Romero ◽

Antonio Bernabe Ortiz ◽

Eric J Velazquez ◽

J. Jaime Miranda ◽

...

Keyword(s):

Blood Pressure ◽

Air Pollution ◽

Systolic Blood Pressure ◽

Self Report ◽

Biomass Fuel ◽

Household Air Pollution ◽

Biomass Fuels ◽

Fuel Use ◽

The Impact ◽

The Relationship

Background: Household air pollution from biomass fuel use affects 3 billion people worldwide. There are few studies that examine the relationship between biomass fuel use and blood pressure. We sought to determine if daily biomass fuel use was associated with higher blood pressure and increased hypertension in Peru. Methods: We analyzed baseline information from an age- and sex-matched, population-based study in Puno, Peru. Daily biomass fuel use was self-reported. Hypertension was defined as a systolic blood pressure (SBP) ≥140 mmHg; diastolic blood pressure (DBP) ≥90 mmHg; or self-report of diagnosis and anti-hypertensive medications. We used linear and logistic multivariable regressions, adjusting for age, sex, daily cigarette use and body mass index, to examine the relationship between daily biomass fuel use with blood pressure and hypertension, respectively. Results: Data from 1004 individuals (mean age 55.3 years, 51.7% female) were included. There was evidence of an association between daily biomass fuel use and hypertension (adjusted OR = 2.1, 95%CI 1.2 to 3.5). Subjects who reported daily use of biomass fuels had 6.0 mmHg (95% CI 4.1 to 8.0) higher SBP and 4.8 mmHg (95%CI 3.5 to 6.0) higher DBP compared to those who did not use biomass fuels daily. In a secondary analysis, we used rural residence (vs. urban) as a proxy of biomass daily use and the relationship with hypertension and systolic blood pressure was similar: a higher odds of hypertension (adjusted OR = 2.1, 95%CI 1.3 to 3.6), and higher SBP (6.7mmHg, 95% CI 4.8 to 8.6) and DBP (5.5 mmHg, 95% CI 4.3 to 6.8) in rural vs. urban participants. Conclusion: Biomass fuel use is associated with increased odds of hypertension and higher blood pressure in Puno, Peru. Reducing exposure to air pollution from biomass fuel use represents a potential opportunity for cardiovascular prevention in rural communities worldwide. Longitudinal studies to evaluate the impact of reducing household air pollution are needed.

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