The small molecule Zaractin activates ZAR1-mediated immunity in Arabidopsis
2021 ◽
Vol 118
(47)
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pp. e2116570118
Keyword(s):
Pathogenic effector proteins use a variety of enzymatic activities to manipulate host cellular proteins and favor the infection process. However, these perturbations can be sensed by nucleotide-binding leucine-rich-repeat (NLR) proteins to activate effector-triggered immunity (ETI). Here we have identified a small molecule (Zaractin) that mimics the immune eliciting activity of the Pseudomonas syringae type III secreted effector (T3SE) HopF1r and show that both HopF1r and Zaractin activate the same NLR-mediated immune pathway in Arabidopsis. Our results demonstrate that the ETI-inducing action of pathogenic effectors can be harnessed to identify synthetic activators of the eukaryotic immune system.
2017 ◽
Vol 114
(10)
◽
pp. E2053-E2062
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2010 ◽
Vol 107
(5)
◽
pp. 2349-2354
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