scholarly journals Late Onset Neuropathy with Spontaneous Clinical Remission in Mice Lacking the POZ Domain of the Transcription Factor Myc-interacting Zinc Finger Protein 1 (Miz1) in Schwann Cells

2014 ◽  
Vol 290 (2) ◽  
pp. 727-743 ◽  
Author(s):  
Adrián Sanz-Moreno ◽  
David Fuhrmann ◽  
Armin Zankel ◽  
Herbert Reingruber ◽  
Lara Kern ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Schwann Cells ◽  
Zinc Finger ◽  
Clinical Remission ◽  
Zinc Finger Protein ◽  
Late Onset ◽  
Finger Protein

scholarly journals Late onset neuropathy with spontaneous clinical remission in mice lacking the POZ domain of the transcription factor Myc-interacting zinc finger protein 1 (Miz1) in Schwann cells.

2015 ◽  
Vol 290 (30) ◽  
pp. 18478-18478 ◽  
Author(s):  
Adrián Sanz-Moreno ◽  
David Fuhrmann ◽  
Armin Zankel ◽  
Herbert Reingruber ◽  
Lara Kern ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Schwann Cells ◽  
Zinc Finger ◽  
Clinical Remission ◽  
Zinc Finger Protein ◽  
Late Onset ◽  
Finger Protein

IL-7R–dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1

Blood ◽  
2011 ◽  
Vol 117 (12) ◽  
pp. 3370-3381 ◽  
Author(s):  
Ingrid Saba ◽  
Christian Kosan ◽  
Lothar Vassen ◽  
Tarik Möröy
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
T Cell ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Strong Reduction ◽  
Expression Levels ◽  
Cell Numbers ◽  
Finger Protein

Abstract T cells originate from early T lineage precursors that have entered the thymus and differentiate through well-defined steps. Mice deficient for the BTB/POZ domain of zinc finger protein-1 (Miz-1) almost entirely lack early T lineage precursors and have a CD4−CD8− to CD4+CD8+ block causing a strong reduction in thymic cellularity. Miz-1ΔPOZ pro-T cells cannot differentiate in vitro and are unable to relay signals from the interleukin-7R (IL-7R). Both STAT5 phosphorylation and Bcl-2 up-regulation are perturbed. The high expression levels of SOCS1 found in Miz-1ΔPOZ cells probably cause these alterations. Moreover, Miz-1 can bind to the SOCS1 promoter, suggesting that Miz-1 deficiency causes a deregulation of SOCS1. Transgenic overexpression of Bcl-2 or inhibition of SOCS1 restored pro-T cell numbers and their ability to differentiate, supporting the hypothesis that Miz-1 is required for the regulation of the IL-7/IL-7R/STAT5/Bcl-2 signaling pathway by monitoring the expression levels of SOCS1.

scholarly journals The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver‐Homing Receptors on Human Blood CD56 bright Natural Killer Cells

2020 ◽  
Vol 4 (3) ◽  
pp. 409-424 ◽  
Author(s):  
Leonard U. Hess ◽  
Glòria Martrus ◽  
Annerose E. Ziegler ◽  
Annika E. Langeneckert ◽  
Wilhelm Salzberger ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Zinc Finger ◽  
Human Blood ◽  
Zinc Finger Protein ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Killer Cells ◽  
Finger Protein

scholarly journals FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

Cell ◽  
1997 ◽  
Vol 90 (1) ◽  
pp. 109-119 ◽  
Author(s):  
Alice P Tsang ◽  
Jane E Visvader ◽  
C.Alexander Turner ◽  
Yuko Fujiwara ◽  
Channing Yu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Megakaryocytic Differentiation ◽  
Finger Protein

scholarly journals Transcriptional activation ofBrassica napusβ-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor

2012 ◽  
Vol 10 (7) ◽  
pp. 783-791 ◽  
Author(s):  
Manju Gupta ◽  
Russell C. DeKelver ◽  
Asha Palta ◽  
Carla Clifford ◽  
Sunita Gopalan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Transcriptional Activation ◽  
Zinc Finger Protein ◽  
Finger Protein ◽  
Protein Transcription

An engineered VEGF‐activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced‐age mice

2006 ◽  
Vol 20 (3) ◽  
pp. 479-481 ◽  
Author(s):  
Jun Yu ◽  
Li Lei ◽  
Yuxin Liang ◽  
Linda Hinh ◽  
Reed P. Hickey ◽  
...  
Keyword(s):  
Blood Flow ◽  
Transcription Factor ◽  
Limb Salvage ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Advanced Age ◽  
Finger Protein ◽  
Protein Transcription
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