scholarly journals Hepatocyte Growth Factor Inhibits Anoikis in Head and Neck Squamous Cell Carcinoma Cells by Activation of ERK and Akt Signaling Independent of NFκB

2002 ◽  
Vol 277 (28) ◽  
pp. 25203-25208 ◽  
Author(s):  
Qinghua Zeng ◽  
Shaoqiong Chen ◽  
Zongbing You ◽  
Fan Yang ◽  
Thomas E. Carey ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Akt Signaling ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Hepatocyte Growth

scholarly journals Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma

2011 ◽  
Vol 102 (12) ◽  
pp. 2164-2171 ◽  
Author(s):  
Dai Susuki ◽  
Sotai Kimura ◽  
Seiji Naganuma ◽  
Katsuki Tsuchiyama ◽  
Toshiaki Tanaka ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Microrna Expression ◽  
Neck Squamous Cell Carcinoma ◽  
Hepatocyte Growth

Serum hepatocyte growth factor as a marker of tumor activity in head and neck squamous cell carcinoma

Oral Oncology ◽  
2007 ◽  
Vol 43 (10) ◽  
pp. 1021-1025 ◽  
Author(s):  
Chul-Ho Kim ◽  
Jin Seok Lee ◽  
Sung-Ook Kang ◽  
Joon-ho Bae ◽  
Sung Pyo Hong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Hepatocyte Growth

Hepatocyte Growth Factor/Scatter Factor Stimulates Mitogenesis and Migration of a Head and Neck Squamous Cell Carcinoma Cell Line

2002 ◽  
Vol 127 (4) ◽  
pp. 271-278 ◽  
Author(s):  
Jeffery Fleigel ◽  
Jack Sedwick ◽  
Lori J. Kornberg
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Cell Line ◽  
Squamous Cell ◽  
Cultured Cells ◽  
Scatter Factor ◽  
Hepatocyte Growth

OBJECTIVE: We sought to assess the effect of extracellular matrix and hepatocyte growth factor/scatter factor (HGF/SF) on the growth and motility of cultured squamous cell carcinoma of the head and neck (SCCHN) cells. METHODS: Cultured cells were incubated in the presence of HGF/SF. The effect of HFG/SF on cell growth, motility, and phosphorylation of the signaling proteins FAK and Erk was determined. RESULTS: HGF/SF is both mitogenic and motogenic to the human SCCHN cell line FaDu. Incubation of FaDu cells in the presence of HGF/SF led to a rapid increase in phosphorylation of both FAK and the growth-promoting kinase Erk. HGF/SF-induced phosphorylation of FAK and Erk was observed in both detached and attached SCCHN cells. However, phosphorylation was much greater in attached cells. CONCLUSIONS AND SIGNIFICANCE: The mitogenic and motogenic activities of HGF/SF may contribute to the pathogenesis of SCCHN in vivo.

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