Faecal microbial contamination of watercress (Nasturtium officinale) gathered by a Maori protocol in New Zealand streams

2009 ◽  
Vol 43 (4) ◽  
pp. 901-910 ◽  
Author(s):  
A. Donnison ◽  
C. Ross ◽  
L. Dixon
2020 ◽  
Vol 130 (1) ◽  
pp. 302-312 ◽  
Author(s):  
B.J. Phiri ◽  
N.P. French ◽  
P.J. Biggs ◽  
M.A. Stevenson ◽  
A.D. Reynolds ◽  
...  

2021 ◽  
Vol 167 ◽  
pp. 104040
Author(s):  
Maria Jesus Gutierrez-Gines ◽  
Hossein Alizadeh ◽  
Elizabeth Alderton ◽  
Vikki Ambrose ◽  
Alexandra Meister ◽  
...  

1995 ◽  
Vol 73 (02) ◽  
pp. 219-222 ◽  
Author(s):  
Manuel Monreal ◽  
Luis Monreal ◽  
Rafael Ruiz de Gopegui ◽  
Yvonne Espada ◽  
Ana Maria Angles ◽  
...  

SummaryThe APTT has been considered the most suitable candidate to monitor the anticoagulant activity of hirudin. However, its use is hampered by problems of standardization, which make the results heavily dependent on the responsiveness of the reagent used. Our aim was to investigate if this different responsiveness of different reagents when added in vitro is to be confirmed in an ex vivo study.Two different doses of r-hirudin (CGP 39393), 0.3 mg/kg and 1 mg/kg, were administered subcutaneously to 20 New Zealand male rabbits, and the differences in prolongation of APTT 2 and 12 h later were compared, using 8 widely used commercial reagents. All groups exhibited a significant prolongation of APTT 2 h after sc administration of hirudin, both at low and high doses. But this prolongation persisted 12 h later only when the PTTa reagent (Boehringer Mannheim) was used. In general, hirudin prolonged the APTT most with the silica- based reagents.In a further study, we compared the same APTT reagents in an in vitro study in which normal pooled plasma was mixed with increasing amount of hirudin. We failed to confirm a higher sensitivity for silica- containing reagents. Thus, we conclude that subcutaneous administration of hirudin prolongs the APTT most with the silica-based reagents, but this effect is exclusive for the ex vivo model.


2011 ◽  
Vol 27 (1) ◽  
pp. 223-226 ◽  
Author(s):  
Shyam Sankaran ◽  
Dorit Naot ◽  
Andrew Grey ◽  
Tim Cundy

2020 ◽  
Vol 76 (3) ◽  
pp. 444-446
Author(s):  
Shilpanjali Jesudason ◽  
Alyssa Fitzpatrick ◽  
Aarti Gulyani ◽  
Christopher E. Davies ◽  
Erandi Hewawasam ◽  
...  

1984 ◽  
Vol 51 (01) ◽  
pp. 075-078 ◽  
Author(s):  
R G Schaub ◽  
C A Simmons

SummaryTwenty-seven adult male New Zealand rabbits (3–4 kgs) were used in this study. Six rabbits received vehicle, 3 groups of 6 each received doses of 4,5-bis(p-methoxyphenyl)-2-(trifluoromethyl)- thiazole, (U-53,059), at 0.3 mg/kg, 3.0 mg/kg and 30.0 mg/kg/day respectively. Drug and vehicle doses were given orally each day starting 3 days before balloon injury and continuing for the entire 2 week time period. Three rabbits were used as nontreated sham controls. In the vehicle and U-53,059 treated groups aortae were denuded of endothelial cells by balloon catheter injury. Two weeks after injury platelet aggregation to collagen was measured and the aortae removed for analysis of surface characteristics by scanning electron microscopy and lesion size by morphometry. All doses of U-53,059 inhibited platelet aggregation. The 3.0 and 30.0 mg/kg groups had the greatest inhibitory effect. All balloon injured aortae had the same morphologic characteristics. All vessels had similar extent and intensity of Evan’s blue staining, similar areas of leukocyte/platelet adhesion, and a myointimal cell cover of transformed smooth muscle cells. The myointimal proliferative response was not inhibited at any of the drug doses studied.


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