The Validity of Social Control Critiques: Psychiatric Medication, Side Effects and Outpatient Commitment

As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus. Here, we describe two cases of patients with cutaneous side effects from Notch inhibitor treatment for adenoid cyst carcinoma (ACC) and review the role of Notch signaling in skin disease. By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.

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The impact on functioning of second-generation antipsychotic medication side effects for patients with schizophrenia: a worldwide, cross-sectional, web-based survey

Annals of General Psychiatry ◽

10.1186/s12991-020-00292-5 ◽

2020 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Rajiv Tandon ◽

William R. Lenderking ◽

Catherine Weiss ◽

Huda Shalhoub ◽

Carla Dias Barbosa ◽

...

Keyword(s):

Side Effects ◽

Antipsychotic Medication ◽

Second Generation ◽

Cross Sectional ◽

Web Based ◽

Medication Side Effects ◽

Medication Side ◽

Second Generation Antipsychotic ◽

The Impact

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Beliefs about medications predict adherence to antidepressants in older adults

International Psychogeriatrics ◽

10.1017/s1041610211001049 ◽

2011 ◽

Vol 24 (1) ◽

pp. 159-169 ◽

Cited By ~ 21

Author(s):

Waleed Fawzi ◽

Mohamed Yousry Abdel Mohsen ◽

Abdel Hamid Hashem ◽

Suaad Moussa ◽

Elizabeth Coker ◽

...

Keyword(s):

Side Effects ◽

Rating Scale ◽

Poor Response ◽

Self Report ◽

Poor Adherence ◽

Response To Treatment ◽

Medication Side Effects ◽

Beliefs About Medicines ◽

Medication Side ◽

Highly Correlated

ABSTRACTBackground: Adherence to treatment is a complex and poorly understood phenomenon. This study investigates the relationship between older depressed patients’ adherence to antidepressants and their beliefs about and knowledge of the medication.Methods: Assessment was undertaken of 108 outpatients over the age of 55 years diagnosed with depressive disorder and treated for at least four weeks with antidepressants. Adherence was assessed using two self-report measures: the Medication Adherence Rating Scale (MARS) and a Global Adherence Measure (GAM). Potential predictors of adherence investigated included sociodemographic, medication and illness variables. In addition, 33 carers were interviewed regarding general medication beliefs.Results: 56% of patients reported 80% or higher adherence on the GAM. Sociodemographic variables were not associated with adherence on the MARS. Specific beliefs about medicines, such as “my health depends on antidepressants” (necessity) and being less worried about becoming dependant on antidepressants (concern) were highly correlated with adherence. General beliefs about medicines causing harm or being overprescribed, experiencing medication side-effects and severity of depression also correlated with poor adherence. Linear regression with the MARS as the dependent variable explained 44.3% of the variance and showed adherence to be higher in subjects with healthy specific beliefs who received more information about antidepressants and worse with depression severity and autonomic side-effects.Conclusions: Our findings strongly support a role for specific beliefs about medicines in adherence. Challenging patients’ beliefs, providing information about treatment and discussing side-effects could improve adherence. Poor response to treatment and medication side-effects can indicate poor adherence and should be considered before switching medications.

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