A systematic appraisal on catalytic synthesis of 1,3-oxazole derivatives: A mechanistic review on metal dependent synthesis

A catalytic synthesis of cyclic guanidines, which are found in many biologically active compounds and natu-ral products, was developed, wherein transition-metal hydrogen atom transfer and radical-polar crossover were employed. This mild and functional-group tolerant process enabled the cyclization of alkenyl guanidines bearing common protective groups, such as Cbz and Boc. This powerful method not only provided the common 5- and 6-membered rings but also an unusual 7-membered ring. The derivatization of the products afforded various heterocycles. We also investigated the se-lective cyclization of mono-protected or hetero-protected (TFA and Boc) alkenyl guanidines and their further derivatiza-tions.

Download Full-text

Structure and Function of Angiopoietin-like Protein 3 (ANGPTL3) in Atherosclerosis

Current Medicinal Chemistry ◽

10.2174/0929867326666190621120523 ◽

2020 ◽

Vol 27 (31) ◽

pp. 5159-5174 ◽

Cited By ~ 4

Author(s):

Xinjie Lu

Keyword(s):

Low Density Lipoprotein ◽

Lipoprotein Metabolism ◽

Density Lipoprotein ◽

Structure And Function ◽

Biological Functions ◽

Pharmacological Management ◽

Vascular Growth ◽

Promising Target ◽

And Function ◽

Systematic Appraisal

Background:Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and cancer. Among them, ANGPTL3 has been shown to regulate the levels of Very Low-Density Lipoprotein (VLDL) made by the liver and play a crucial role in human lipoprotein metabolism.Method:A systematic appraisal of ANGPTLs was conducted, focusing on the main features of ANGPTL3 that has a significant role in atherosclerosis.Results:Angiopoietins including ANGPTL3 are vascular growth factors that are highly specific for endothelial cells, perform a variety of other regulatory activities to influence inflammation, and have been shown to possess both pro-atherosclerotic and atheroprotective effects.Conclusion:ANGPTL3 has been demonstrated as a promising target in the pharmacological management of atherosclerosis. However, many questions remain about its biological functions.

Download Full-text

Recent Developments in the Catalytic Synthesis of 2-Substituted Benzoxazoles

Current Organic Chemistry ◽

10.2174/1385272821666170623080714 ◽

2017 ◽

Vol 21 (19) ◽

Cited By ~ 6

Author(s):

Jian He

Keyword(s):

Catalytic Synthesis ◽

Recent Developments

Download Full-text

Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using Activated Montmorillonite as Catalyst

Letters in Organic Chemistry ◽

10.2174/1570178615666180627113617 ◽

2018 ◽

Vol 16 (1) ◽

pp. 59-65

Author(s):

Sofiane Mekki ◽

Lahcen Krabia ◽

Saleh Mahmoud Saleh Mohamed ◽

Salima Saidi-Besbes

Keyword(s):

Catalytic Synthesis ◽

Montmorillonite Clays

An efficient catalytic synthesis of 4-aryl-3,4-dihydropyrimidine-2(1H)-one derivatives using copper (II), iron (III) and zinc (II) exchanged montmorillonite clays as a catalyst is described. The desired products were obtained in good yields.

Download Full-text