Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/a

Evidence from previous studies has reported that complex traits, including psychiatric disorders, are moderately to highly heritable. Moreover, it has also been shown that specific personality traits may increase the risk to develop mental illnesses. Therefore the focus of the research shifted towards the identification of the biological mechanisms underpinning these traits by exploring the effects of a constellation of genetic polymorphisms in healthy subjects. Indeed, studying the effect of genetic variants in normal personality provides a unique means for identifying candidate genes which may increase the risk for psychiatric disorders. In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors. The main aims are: (a) to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship; and (b) to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits.

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Influences of ABC transporter and CYP3A4/5 genetic polymorphisms on the pharmacokinetics of lenvatinib in Chinese healthy subjects

European Journal of Clinical Pharmacology ◽

10.1007/s00228-020-02879-z ◽

2020 ◽

Vol 76 (8) ◽

pp. 1125-1133

Author(s):

Jiaming Li ◽

Xiaoqian Wang ◽

Chen Ning ◽

Zhaoyu Wang ◽

Yao Wang ◽

...

Keyword(s):

Genetic Polymorphisms ◽

Abc Transporter ◽

Healthy Subjects

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Effects of ABCB1 , UGT1A1 , and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects

Clinical Pharmacology in Drug Development ◽

10.1002/cpdd.848 ◽

2020 ◽

Author(s):

Lu‐Ning Sun ◽

Guo‐Xian Sun ◽

Yu‐Qing Yang ◽

Ye Shen ◽

Feng‐Ru Huang ◽

...

Keyword(s):

Genetic Polymorphisms ◽

Healthy Subjects

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Determination of NLRP3 (rs4612666) and IL-1B (rs1143634) genetic polymorphisms in periodontally diseased and healthy subjects

Archives of Oral Biology ◽

10.1016/j.archoralbio.2016.01.013 ◽

2016 ◽

Vol 65 ◽

pp. 44-51 ◽

Cited By ~ 13

Author(s):

Diana M. Isaza-Guzmán ◽

Melissa Hernández-Viana ◽

Diego M. Bonilla-León ◽

María C. Hurtado-Cadavid ◽

Sergio I. Tobón-Arroyave

Keyword(s):

Genetic Polymorphisms ◽

Healthy Subjects

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Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of levosulpiride in healthy subjects

Neuroscience ◽

10.1016/j.neuroscience.2010.04.065 ◽

2010 ◽

Vol 169 (1) ◽

pp. 378-387 ◽

Cited By ~ 14

Author(s):

H.Y. Cho ◽

H.D. Yoo ◽

Y.B. Lee

Keyword(s):

Genetic Polymorphisms ◽

Healthy Subjects

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Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of risperidone in healthy subjects with CYP2D6 * 10 /* 10

British Journal of Pharmacology ◽

10.1111/j.1476-5381.2011.01385.x ◽

2011 ◽

Vol 164 (2b) ◽

pp. 433-443 ◽

Cited By ~ 32

Author(s):

Hee‐Doo Yoo ◽

Sang‐No Lee ◽

Hyun‐Ah Kang ◽

Hea‐Young Cho ◽

Il‐Kwon Lee ◽

...

Keyword(s):

Genetic Polymorphisms ◽

Healthy Subjects

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The role of glutathione S-transferase M1 and T1 gene polymorphisms and fruit and vegetable consumption in antioxidant parameters in healthy subjects

British Journal Of Nutrition ◽

10.1017/s0007114511003746 ◽

2011 ◽

Vol 107 (6) ◽

pp. 928-933 ◽

Cited By ~ 10

Author(s):

Lin-Hong Yuan ◽

Li-Ping Meng ◽

Wei-Wei Ma ◽

Sheng Li ◽

Jin-Fang Feng ◽

...

Keyword(s):

Vitamin C ◽

Genetic Polymorphisms ◽

Healthy Subjects ◽

Large Scale ◽

Fruits And Vegetables ◽

Vegetable Consumption ◽

Plasma Vitamin ◽

Mean Values ◽

Antioxidant Parameters ◽

Gst Activity

The correlation of glutathione S-transferase (GST) M1/T1 genetic polymorphisms with oxidative stress-related chronic diseases was proved recently. The aim of the present study was to investigate the association of GSTM1/T1 genetic polymorphisms with antioxidant biomarkers and consumption of fruits and vegetables (F&V) in healthy subjects. In this study, for conducting a 3 d dietary survey, 190 healthy adults were recruited. After DNA extraction, a multiple PCR method was used for GSTM1/T1 genotyping. A spectrophotometer method was applied for the determination of plasma total antioxidant capacity (T-AOC), vitamin C level and erythrocyte GST enzyme activity. A general linear model was used to compare the mean values of antioxidant parameters for different GSTM1/T1 genotypes and consumption of F&V. Polymorphisms of GSTM1/T1 had no effects on plasma T-AOC and vitamin C levels. Deletion of the GSTM1 gene decreased the erythrocyte GST activity. There was correlation between plasma T-AOC and consumption of F&V in the GSTM1− or GSTT1+ subjects. A similar pattern was evident for erythrocyte GST activity in the GSTM1− subjects. No association was found among consumption of F&V and GSTM1/T1 genotypes and plasma vitamin C level. Different consumption of F&V had no impact on plasma T-AOC and vitamin C levels in the GSTM1−/GSTT1+ or GSTM1−/GSTT1− subjects. The erythrocyte GST activity was more sensitive to consumption of F&V in the individuals with the GSTM1−/GSTT1+ genotype. Association was found among GSTM1/T1 genotypes, antioxidant parameters and consumption of F&V. Large-scale and multiple ethnic studies are needed to further evaluate the relationship.

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Serine proteases of the complement lectin pathway and their genetic variations in ischaemic stroke

Journal of Clinical Pathology ◽

10.1136/jclinpath-2017-204403 ◽

2017 ◽

Vol 71 (2) ◽

pp. 141-147 ◽

Cited By ~ 3

Author(s):

Gohar Tsakanova ◽

Ani Stepanyan ◽

Karen Nahapetyan ◽

Robert B Sim ◽

Arsen Arakelyan ◽

...

Keyword(s):

Ischaemic Stroke ◽

Genetic Polymorphisms ◽

Serine Proteases ◽

Healthy Subjects ◽

Lectin Pathway ◽

Nucleotide Polymorphisms ◽

Ischaemic Brain ◽

Proteolytic Activities ◽

Ischaemic Brain Damage ◽

Armenian Population

AimsThe aim of the current study was to assess the proteolytic activities of collectin-bound MASP-1 and MASP-2 in the blood of patients with ischaemic stroke, as well as the association of their six genetic polymorphisms (rs3203210, rs28945070, rs28945073 in MASP1 gene and rs2273343, rs12711521, rs147270785 in MASP2 gene) with this pathology.MethodsIn total, 250 patients and 300 healthy subjects were involved in this study. MBL-associated serine protease (MASP)-1 and MASP-2 activities were measured using in-house developed immunofluorescent and enzyme-linked immunosorbent assays, respectively. Sequence specific primer PCR was used to study the association of MASP1 and MASP2 genetic polymorphisms with ischaemic stroke.ResultsThe results obtained demonstrate that the activities of collectin-bound MASP-1 and MASP-2 in patients with ischaemic stroke are significantly higher than those in healthy subjects (p<0.001). According to the data obtained for genotyping, the rs3203210 polymorphism in the MASP1 gene and the rs147270785 polymorphism in the MASP2 gene are associated with ischaemic stroke (p<0.0001).ConclusionsIn conclusion we suggest that the complement lectin pathway serine proteases, MASP-1 and MASP-2, can be associated with ischaemic stroke development risk and may participate in pathological events leading to post-ischaemic brain damage. Moreover rs3203210 and rs147270785 single nucleotide polymorphisms in the MASP1 and MASP2 genes, respectively, are strongly associated with ischaemic stroke, and the minor rs3203210*C and rs147270785*A alleles of these polymorphisms may be considered as protective factors for ischameic stroke, at least in the Armenian population.

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