Progesterone elevation on the day of oocyte retrieval and live birth rate after in vitro fertilisation treatment

2021 ◽  
pp. 1-5
Author(s):  
Maria Angeles Roque Fernandez ◽  
Cristina Alvarez Lleo ◽  
Esteban Gonzalez Mirasol ◽  
Maria Resta Serra ◽  
Carmen Garcia Garrido ◽  
...  
Keyword(s):  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Oocyte Retrieval ◽  
In Vitro Fertilisation ◽  
Fertilisation Treatment

scholarly journals Triple-arm trial of pH (Tri-pH) effect on live birth after ICSI in Egyptian IVF facilities: protocol of a randomised controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. e034194
Author(s):  
Mohamed Fawzy ◽  
Mai Emad ◽  
Jack Wilkinson ◽  
Ragaa Mansour ◽  
Ali Mahran ◽  
...  
Keyword(s):  
Live Birth ◽  
Embryo Culture ◽  
Birth Rate ◽  
Randomised Trial ◽  
Live Birth Rate ◽  
Embryo Cryopreservation ◽  
In Vitro Fertilisation ◽  
Safety Committee ◽  
Ph Range

IntroductionOne potential stressor that can affect preimplantation and postimplantation embryonic growth after in vitro fertilisation (IVF) is the pH of the human embryo culture medium, but no evidence exists to indicate which pH level is optimal for IVF. Based on anecdotal evidence or mouse models, culture media manufacturers recommend a pH range of 7.2 to 7.4, and IVF laboratories routinely use a pH range of 7.25 to 7.3. Given the lack of randomised trials evaluating the effect of pH on live birth rate after IVF, this trial examines the effect of three different pH levels on the live birth rate.Methods and analysisThis multicentre randomised trial will involve centres specialised in IVF in Egypt. Eligible couples for intracytoplasmic sperm injection (ICSI) will be randomised for embryo culture at pH 7.2, 7.3 or 7.4. The study is designed to detect 10 percentage points difference in live birth rate between the best and worst performing media with 93% power at a 1% significance level. The primary outcome is the rate of live birth (delivery of one or more viable infants beyond the 20th week of gestation) after ICSI. Secondary clinical outcomes include biochemical pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, preterm births, birth weight, stillbirth, congenital malformation and cumulative live birth (within 1 year from randomisation). Embryo development outcomes include fertilisation, blastocyst formation and quality, and embryo cryopreservation and utilisation.Ethics and disseminationThe study was reviewed and approved by the Ethics Review Boards of the participating centres. Eligible women will sign a written informed consent before enrolment. This study has an independent data monitoring and safety committee comprised international experts in trial design and in vitro culture. No plan exists to disseminate results to participants or health communities, except for the independent monitoring and safety committee of the trial.Trial registration numberNCT02896777.

scholarly journals Vitamin D supplementation prior to in vitro fertilisation in women with polycystic ovary syndrome: a protocol of a multicentre randomised, double-blind, placebo-controlled clinical trial

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e041409
Author(s):  
Kai-Lun Hu ◽  
Kwanghann Gan ◽  
Rui Wang ◽  
Wentao Li ◽  
Qiongfang Wu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Informed Consent ◽  
Live Birth ◽  
Birth Rate ◽  
Polycystic Ovary ◽  
Live Birth Rate ◽  
Vitamin D Supplementation ◽  
In Vitro Fertilisation ◽  
Ovary Syndrome

IntroductionPolycystic ovary syndrome (PCOS) is one of the leading causes of female infertility, affecting around 5% of women of childbearing age in China. Vitamin D insufficiency is common in women with PCOS and is associated with lower live birth rates. However, evidence regarding the effectiveness of vitamin D supplementation in women with PCOS is inconclusive. This multicentre randomised, double-blinded, placebo-controlled trial aims to evaluate the effectiveness of vitamin D supplementation prior to in vitro fertilisation (IVF) on the live birth rate in women with PCOS.Methods and analysisWe plan to enrol women with PCOS scheduled for IVF. After informed consent, eligible participants will be randomised in a 1:1 ratio to receive oral capsules of 4000 IU vitamin D per day or placebo for around 12 weeks until the day of triggering. All IVF procedures will be carried out routinely in each centre. The primary outcome is live birth after the first embryo transfer. The primary analysis will be by intention-to-treat analysis. To demonstrate or refute that treatment with vitamin D results in a 10% higher live birth rate than treatment with placebo, we need to recruit 860 women (48% vs 38% difference, anticipating 10% loss to follow-up and non-compliance, significance level 0.05 and power 80%).Ethics and disseminationThis study has been approved by the Ethics Committee in Women’s Hospital of Zhejiang University on 2 March 2020 (reference number: IRB-20200035-R). All participants will provide written informed consent before randomisation. The results of the study will be submitted to scientific conferences and a peer-reviewed journal.Trial registration numberNCT04082650.

scholarly journals Association between baseline LH/FSH and live-birth rate after fresh-embryo transfer in polycystic ovary syndrome women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nian-jun Su ◽  
Cui-yu Huang ◽  
Jie Liu ◽  
De-ying Kang ◽  
Song-lu Wang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Embryo Transfer ◽  
Live Birth ◽  
Birth Rate ◽  
Polycystic Ovary ◽  
Live Birth Rate ◽  
In Vitro Fertilisation ◽  
Fresh Embryo Transfer ◽  
Ovary Syndrome

AbstractThis study aimed to retrospectively analyse the effect of the baseline luteinising hormone/follicle-stimulating hormone ratio (bLH/FSH) on the live-birth rate per fresh-embryo transfer cycle (LBR/ET) in infertile women with polycystic ovary syndrome (PCOS) who received a fresh-embryo transfer. A total of 424 patients with PCOS who underwent the first cycle of in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) fresh-embryo transfer at our hospital was enrolled. Univariate and multivariate logistic regression analyses, along with curve fitting and a threshold effect analysis, were performed. Baseline LH/FSH levels were a significant (P < 0.05) independent risk factor affecting live birth. In the first IVF/ICSI antagonist treatment cycles, LBR/ET after fresh-embryo transfer was relatively flat, until bLH/FSH was 1.0; thereafter, it started to decrease by 17% for every 0.1-unit bLH/FSH increase. Considering the decline in LBR/ET, it is recommended that PCOS women with bLH/FSH > 1.0 carefully consider fresh-embryo transfer during their first IVF/ICSI.

scholarly journals Cumulative live birth rates over multiple complete cycles of in vitro fertilisation cycles: ten-year cohort study of 20687 women following freeze-all strategy

2020 ◽  
Author(s):  
Qianqian Zhu ◽  
Bian Wang ◽  
Jiaying Lin ◽  
Mingru Yin ◽  
yun Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Live Birth ◽  
Birth Rate ◽  
Prediction Models ◽  
Live Birth Rate ◽  
In Vitro Fertilisation ◽  
Cumulative Live Birth Rate ◽  
Complete Cycle ◽  
Cumulative Live Birth

Abstract Background For patients embarking on in vitro fertilization (IVF) or Intracytoplasmic sperm injection (ICSI), one of the most concerned problems is their chance of a live-birth. The cumulative live birth rate (CLBR) after IVF has been reported in recent years; however these studies were all about conventional IVF strategy, the CLBRs following freeze-all strategy has not been reported. Methods This was a retrospective cohort study. A total of 20687 women undergoing their first and following IVF cycles during the period from January 1, 2007 through March 31, 2016 were included in this study. The primary Outcomes of the present study were presented in three types: the live birth rate per complete cycle, the conservative CLBR and the optimal CLBR. Results The CLBR increased from 50.74% for the first complete cycle to 64.41% after seven complete cycles,and varied by age category. The CLBR after five complete cycles declined from 77.11% for women younger than 31 years, to 8.63% for women older than 40 years. The predictors of live birth over multiple complete cycles for patients embarking on IVF following freeze-all strategy were women’s age and causes of infertility. In the model constructed for patients finishing the first complete cycle, the number of oocyte retrieved at complete cycle one also played an important predictive role. Conclusions Among women undergoing IVF following freeze-all strategy, the CLBR after seven complete IVF cycles was 84.77% if there were no barriers to continue the IVF treatment, with variation by age. Two prediction models were developed to estimate their probability of having a baby over multiple complete IVF cycles with freeze-all strategy among patients before starting IVF and patients after the first complete cycle, which is critical for patients to make treatment decisions and preparations physically, emotionally and financially.

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