Distribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb/c mice

2022 ◽  
pp. 1-17
Author(s):  
Omer Burak Ericek ◽  
Kübra Akillioglu ◽  
Dilek Saker ◽  
Ibrahim Cevik ◽  
Meltem Donmez Kutlu ◽  
...  
Keyword(s):  
IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S199
Author(s):  
Omer Burak Ericek ◽  
Dervis Mansuri Yilmaz ◽  
Ibrahim Cevik ◽  
Dilek Saker ◽  
Meltem Donmez Kutlu ◽  
...  
Keyword(s):  

2020 ◽  
Vol 23 (7) ◽  
pp. 459-468 ◽  
Author(s):  
Xuejiao Wang ◽  
Yingzhuo Li ◽  
Jingyu Chen ◽  
Zijie Li ◽  
Jinhong Li ◽  
...  

Abstract Background Systemic administration of noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists such as MK-801 is widely used to model psychosis of schizophrenia (SZ). Acute systemic MK-801 in rodents caused an increase of the auditory steady-state responses (ASSRs), the oscillatory neural responses to periodic auditory stimulation, while most studies in patients with SZ reported a decrease of ASSRs. This inconsistency may be attributable to the comprehensive effects of systemic administration of MK-801. Here, we examined how the ASSR is affected by selectively blocking NMDAR in the thalamus. Methods We implanted multiple electrodes in the auditory cortex (AC) and prefrontal cortex to simultaneously record the local field potential and spike activity (SA) of multiple sites from awake mice. Click-trains at a 40-Hz repetition rate were used to evoke the ASSR. We compared the mean trial power and phase-locking factor and the firing rate of SA before and after microinjection of MK-801 (1.5 µg) into the medial geniculate body (MGB). Results We found that both the AC and prefrontal cortex showed a transient local field potential response at the onset of click-train stimulus, which was less affected by the application of MK-801 in the MGB. Following the onset response, the AC also showed a response continuing throughout the stimulus period, corresponding to the ASSR, which was suppressed by the application of MK-801. Conclusion Our data suggest that the MGB is one of the generators of ASSR, and NMDAR hypofunction in the thalamocortical projection may account for the ASSR deficits in SZ.


2006 ◽  
Vol 16 ◽  
pp. S46-S47
Author(s):  
X. López-Gil ◽  
Z. Babot ◽  
M. Amargós-Bosch ◽  
C. Suñol ◽  
F. Artigas ◽  
...  
Keyword(s):  

2012 ◽  
Vol 63 (4) ◽  
pp. 575-581 ◽  
Author(s):  
Nicole L. Roenker ◽  
Gary A. Gudelsky ◽  
Rebecca Ahlbrand ◽  
Paul S. Horn ◽  
Neil M. Richtand

2013 ◽  
Vol 25 (5) ◽  
pp. 1348-1361 ◽  
Author(s):  
K. Blot ◽  
S.-i. Kimura ◽  
J. Bai ◽  
A. Kemp ◽  
D. Manahan-Vaughan ◽  
...  

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