scholarly journals Clinical Features and Outcome of Sickle Cell Disease in a Tertiary Center in Northern Lebanon: A Retrospective Cohort Study in a Local, Hospital-Associated Registry

Hemoglobin ◽  
2021 ◽  
pp. 1-7
Author(s):  
Adlette Inati ◽  
Chadi Al Alam ◽  
Cristel El Ojaimi ◽  
Taghrid Hamad ◽  
Hemanth Kanakamedala ◽  
...  
PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 264A-264A
Author(s):  
Parth J. Bhatt ◽  
Dinesh Singh ◽  
Akingbola Olubenga ◽  
Devraj Chavda ◽  
Achint Patel

2020 ◽  
Vol 13 (2) ◽  
pp. 186-192 ◽  
Author(s):  
Narcisse Elenga ◽  
Donald Celicourt ◽  
Blandine Muanza ◽  
Gisèle Elana ◽  
Sévérine Hocquelet ◽  
...  

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Angela Edna Rankine-Mullings ◽  
Twila Mae Logan ◽  
Lesley-Gaye King ◽  
Colette Andrea Cunningham-Myrie ◽  
Clive Robert Scott ◽  
...  

2020 ◽  
Vol 25 (7) ◽  
pp. 897-904
Author(s):  
Joseph Ssenyondwa ◽  
Paul E. George ◽  
Juan Carlos Bazo‐Alvarez ◽  
Rebecca Mercedes ◽  
Jacqueline B. Kanywa ◽  
...  

2010 ◽  
Vol 3 (3) ◽  
pp. 110-112 ◽  
Author(s):  
A R Chase ◽  
M Sohal ◽  
J Howard ◽  
R Laher ◽  
A McCarthy ◽  
...  

The objective of this retrospective cohort study from two tertiary centres in the UK was to describe the pregnancy outcomes of women with sickle cell disease (SCD) who booked at these centres between 2004 and 2008, and to compare this with historical data. The study population comprised 122 singleton pregnancies in women with SCD: homozygous sickle cell disease 64, sickle cell haemoglobin C disease 45, sickle b plus thalassaemia 11, sickle cell haemoglobin E disease 1 and sickle cell delta disease 1 from 2004 to 2008 managed in the joint haematology/obstetric antenatal clinics in two tertiary teaching hospitals. The main outcome measures were the frequency of sickle cell crises and obstetric complications. Age and gestation at booking were 18–43 years (mean 29.7) and 9–36 weeks gestation (mean 17.3), respectively. Complications of SCD occurred in 25% of pregnancies. Fifty-four percent of women had induction of labour and 39% were delivered by emergency caesarean section. Thirty-three percent had a postpartum haemorrhage. Nineteen percent of women delivered before 37 completed weeks. Birth weight below 2500 g occurred in 20% of singleton pregnancies. Three neonates developed transient complications related to maternal opiate exposure postnatally. Three intrauterine deaths occurred at 24, 29 and 34 weeks. Two of these had congenital defects, and the other severe intrauterine growth restriction. No maternal deaths occurred. Successful pregnancy outcomes can be achieved in SCD. There has been an improvement in fetal and maternal morbidity and mortality compared with historical data. Pregnancy in women with SCD remains high risk. Early access to antenatal care and to expertise in SCD is essential. A matched control population from the same time period and prospective data collection is needed to address confounders such as ethnicity and deprivation.


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