scholarly journals Sigma-2 receptor ligand anchored telmisartan loaded nanostructured lipid particles augmented drug delivery, cytotoxicity, apoptosis and cellular uptake in prostate cancer cells

2016 ◽  
Vol 42 (12) ◽  
pp. 2020-2030 ◽  
Author(s):  
Richa Puri ◽  
Richa Kaur Bhatia ◽  
Ravi Shankar Pandey ◽  
Upendra Kumar Jain ◽  
Om Prakash Katare ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Prostate Cancer Cells ◽  
Receptor Ligand ◽  
Lipid Particles

Discovery of peptide drug carrier candidates for targeted multi-drug delivery into prostate cancer cells

2017 ◽  
Vol 408 ◽  
pp. 164-173 ◽  
Author(s):  
O. Bashari ◽  
B. Redko ◽  
A. Cohen ◽  
G. Luboshits ◽  
G. Gellerman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Carrier ◽  
Peptide Drug ◽  
Prostate Cancer Cells

scholarly journals Telomerase Inhibition, Telomere Shortening, and Cellular Uptake of the Perylene Derivatives PM2 and PIPER in Prostate Cancer Cells

2019 ◽  
Vol 42 (6) ◽  
pp. 906-914 ◽  
Author(s):  
Navakoon Kaewtunjai ◽  
Ratasark Summart ◽  
Ariyaphong Wongnoppavich ◽  
Bannakij Lojanapiwat ◽  
T. Randall Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Prostate Cancer Cells ◽  
Telomere Shortening ◽  
Telomerase Inhibition ◽  
Perylene Derivatives

A Resveratrol-Loaded Poly(2-hydroxyethyl methacrylate)-Chitosan Based Nanotherapeutic: Characterization and In Vitro Cytotoxicity Against Prostate Cancer

2021 ◽  
Vol 21 (4) ◽  
pp. 2090-2098
Author(s):  
Erdal Eroglu
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Human Prostate ◽  
Great Promise ◽  
Hydroxyethyl Methacrylate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Delivery Efficiency

The delivery of therapeutic molecules such as drugs, nucleic acids, or other active molecules into the target tissue and cells is limited because of biological and cellular barriers. Recently, many efforts are being made to bypass these barriers using nanosized drug delivery vehicles. For the targeted transfer of anticancer agents into the cancer tissue with higher efficiency and lower cellular toxicity, synthesis of nano-scale smart materials hold great promise due to the enhanced permeability and retention capability. Encapsulation of natural anticancer compounds such as resveratrol displaying low water-solubility and poor chemical stability into nanomaterials are intensely being studied to achieve the enhanced anticancer activity. The aim of this study is to investigate the drug delivery efficiency of the poly(2-hydroxyethyl methacrylate) (pHEMA)-chitosan nanoparticles (PCNPs) against PC-3 human prostate cancer cells In Vitro. To achieve this aim, resveratrol (RES), one of the widely known natural anticancer agent, is encapsulated into pHEMA core and pHEMARES nanospheres were coated with a cationic polymer, chitosan. Then, developed PCNPs-RES complexes were characterized using fourier transformed infrared (FTIR) spectroscopy, ultraviolet (UV) visible spectroscopy, scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential and atomic force microscopy (AFM) analyses. The characterization studies revealed the synthesis of PCNPs nanoparticles and the entrapment of RES into PCNPs. Also, the cytotoxicity and drug delivery efficiency of PCNPs-RES complexes were tested in human prostate cancer cells, PC-3, In Vitro. As a consequence, PCNPs was shown to be a promising candidate as a new generation nanotherapeutic against prostate cancer In Vitro.

scholarly journals Synthesis, characterization and cellular location of cytotoxic constitutional organometallic isomers of rhenium delivered on a cyanocobalmin scaffold

2015 ◽  
Vol 44 (15) ◽  
pp. 6999-7008 ◽  
Author(s):  
Giuseppe Santoro ◽  
Theodora Zlateva ◽  
Albert Ruggi ◽  
Luca Quaroni ◽  
Fabio Zobi
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Vitamin B ◽  
Prostate Cancer Cells ◽  
Cellular Location ◽  
3T3 Fibroblasts

Constitutional isomers based on vitamin B12 and a fluorescent rhenium diimine complex were prepared, characterized, tested against PC-3 prostate cancer cells and investigated via IR spectromicroscopy for cellular uptake by live 3T3 fibroblasts.

scholarly journals Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ezgi Oner ◽  
Mustafa Kotmakci ◽  
Anne-Marie Baird ◽  
Steven G. Gray ◽  
Bilge Debelec Butuner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Transfection Efficiency ◽  
3D Culture ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Great Promise ◽  
Prostate Cancer Cells ◽  
Tumor Spheroids

Abstract Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, and effective carriers are needed. Results Here, we developed cationic solid lipid nanoparticles (cSLNs) to carry siRNAs targeting EphA2 receptor tyrosine kinase (siEphA2), which is overexpressed in many solid tumors including prostate cancer. Using DDAB cationic lipid instead of DOTMA reduced nanoparticle size and enhanced both cellular uptake and gene silencing in prostate cancer cells. DDAB-cSLN showed better cellular uptake efficiency with similar silencing compared to commercial transfection reagent (Dharmafect 2). After verifying the efficacy of siEphA2-loaded nanoparticles, we further evaluated a potential combination with a histone lysine demethylase inhibitor, JIB-04. Silencing EphA2 by siEphA2-loaded DDAB-cSLN did not affect the viability (2D or 3D culture), migration, nor clonogenicity of PC-3 cells alone. However, upon co-administration with JIB-04, there was a decrease in cellular responses. Furthermore, JIB-04 decreased EphA2 expression, and thus, silencing by siEphA2-loaded nanoparticles was further increased with co-treatment. Conclusions We have successfully developed a novel siRNA-loaded lipid nanoparticle for targeting EphA2. Moreover, preliminary results of the effects of JIB-04, alone and in combination with siEphA2, on prostate cancer cells and prostate cancer tumor spheroids were presented for the first time. Our delivery system provides high transfection efficiency and shows great promise for targeting other genes and cancer types in further in vitro and in vivo studies.

scholarly journals Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

2015 ◽  
Vol 220 ◽  
pp. 727-737 ◽  
Author(s):  
Heikki Saari ◽  
Elisa Lázaro-Ibáñez ◽  
Tapani Viitala ◽  
Elina Vuorimaa-Laukkanen ◽  
Pia Siljander ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Prostate Cancer Cells
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