MicroRNA-30a Targets Notch1 to Alleviate Podocyte Injury in Lupus Nephritis

2022 ◽  
pp. 1-13
Author(s):  
Aoyang Guo ◽  
Yadi Sun ◽  
Xiaona Xu ◽  
Qian Xing
2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii109-iii110
Author(s):  
Francisco V Veronese ◽  
Mariane dos Santos ◽  
Rafael N Bringhenti ◽  
Patrícia G Rodrigues ◽  
Jonathan F do Nascimento ◽  
...  

2019 ◽  
Vol 234 (9) ◽  
pp. 16191-16204 ◽  
Author(s):  
Ling Sun ◽  
Lu‐Xi Zou ◽  
Yu‐Chen Han ◽  
Ling Wu ◽  
Ting Chen ◽  
...  

2019 ◽  
Vol 8 (9) ◽  
pp. 1340 ◽  
Author(s):  
Hamza Sakhi ◽  
Anissa Moktefi ◽  
Khedidja Bouachi ◽  
Vincent Audard ◽  
Carole Hénique ◽  
...  

Systemic lupus erythematosus (SLE) is characterized by a broad spectrum of renal lesions. In lupus glomerulonephritis, histological classifications are based on immune-complex (IC) deposits and hypercellularity lesions (mesangial and/or endocapillary) in the glomeruli. However, there is compelling evidence to suggest that glomerular epithelial cells, and podocytes in particular, are also involved in glomerular injury in patients with SLE. Podocytes now appear to be not only subject to collateral damage due to glomerular capillary lesions secondary to IC and inflammatory processes, but they are also a potential direct target in lupus nephritis. Improvements in our understanding of podocyte injury could improve the classification of lupus glomerulonephritis. Indeed, podocyte injury may be prominent in two major presentations: lupus podocytopathy and glomerular crescent formation, in which glomerular parietal epithelial cells play also a key role. We review here the contribution of podocyte impairment to different presentations of lupus nephritis, focusing on the podocyte signaling pathways involved in these lesions.


Lupus ◽  
2013 ◽  
Vol 23 (3) ◽  
pp. 255-262 ◽  
Author(s):  
GM Rezende ◽  
VS Viana ◽  
DMAC Malheiros ◽  
EF Borba ◽  
NAS Silva ◽  
...  

2021 ◽  
Vol 46 (3) ◽  
pp. 305-313
Author(s):  
Yunxia Yu ◽  
Caixia Zhu ◽  
Nan Yu ◽  
Lijuan Yang

Lupus ◽  
2016 ◽  
Vol 25 (14) ◽  
pp. 1577-1586 ◽  
Author(s):  
R Ma ◽  
W Jiang ◽  
Z Li ◽  
Y Sun ◽  
Z Wei

Proteinuria is the hallmark of clinical manifestation of disease activity in lupus nephritis (LN) patients, which arises from direct or indirect podocyte injury. This study is to explore the relationship between intrarenal T cell infiltration and podocyte injury in lupus nephritis (LN), and to understand the potential mechanisms of podocyte injury induced by intrarenal T cells. Sixty renal biopsies from patients diagnosed with LN were included in the present study. Histological changes in LN patients were detected by light and electron microscopy. Podocyte-specific nephrin expression in renal tissues was detected by immunofluorescence. Infiltration of T cells (CD3+ cells), infiltration of macrophages (CD68+ cells) and the expression of osteopontin (OPN) in renal tissues were examined by immunohistochemical staining. Pearson or Spearman’s tests were used to perform correlation analysis. Morphologic lesions of podocytes were more severe in LN patients than in normal control subjects. Compared with normal control subjects, nephrin expression was significantly decreased in LN patients. The expression level of nephrin was significantly lower in active LN patients than in the inactive group of patients ( P < 0.05). Compared with normal control subjects, the number of infiltrated intrarenal T cells and macrophages was significantly increased in LN patients. T cells were mainly distributed in renal interstitium, with very few being in glomeruli, while macrophages were mainly located in glomeruli. The number of intrarenal infiltrated T cells and macrophages in active LN patients was more than that in the inactive group ( P < 0.05). Compared with normal control subjects, OPN expression in LN patients was increased significantly. The expression level of OPN in active LN patients was significantly higher than that in the inactive group ( P < 0.05). Podocyte-specific nephrin was negatively correlated with 24-hour proteinuria, intrarenal T cells infiltration and intrarenal OPN expression in LN patients ( P < 0.001). Intrarenal macrophages had significantly positive correlation with intrarenal OPN expression ( P < 0.001). The present study provides possible links between intrarenal T cells, OPN, macrophages with reduced podocyte-nephrin and podocytopathy in systemic lupus erythematosus. In addition, infiltration of macrophages in glomeruli induced by OPN that is induced by T cells may be a crucial mechanism for podocyte injury.


2017 ◽  
Vol 46 (5) ◽  
pp. 632-641 ◽  
Author(s):  
Mariane dos Santos ◽  
Priscila Tamar Poletti ◽  
Patrícia Milhoransa ◽  
Odirlei André Monticielo ◽  
Francisco Veríssimo Veronese

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