Jump Technique versus Seton Method for Anal Fistula Repair: A Randomized Controlled Trial

2022 ◽  
pp. 1-7
Author(s):  
Jalaluddin Khoshnevis ◽  
Roberto Cuomo ◽  
Farzaneh Karami ◽  
Terifeh Dashti ◽  
Alireza Kalantar Motamedi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Anal Fistula ◽  
Controlled Trial ◽  
Fistula Repair ◽  
Randomized Controlled

scholarly journals Effect of Paula exercise method on functional outcomes of women with post fistula repair incontinence: a protocol for randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Saratu Umar Aliyu ◽  
Shmaila M. Hanif ◽  
Isa Usman Lawal
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Randomized Controlled Trial ◽  
Pelvic Floor ◽  
Controlled Trial ◽  
Fistula Repair ◽  
Randomized Controlled ◽  
Urine Leakage ◽  
Pelvic Floor Strength

Abstract Background Post-fistula-repair incontinence (PFRI) is a common complication of vesicovaginal fistula (VVF) surgeries. It entails continuous leakage of urine after successful VVF closure. Pelvic Floor Muscle Training (PFMT) plays a vital role in the management of PFRI, however, an evolving exercise approach is the Paula Exercise Method (PEM) which has shown a promising effect in stopping urinary incontinence, but there is no data on its effect on PFRI. This study therefore, proposes to primarily investigate the effect of PEM on urine leakage and secondarily, pelvic floor strength (PFS), quality of life (QoL), sexual function (SF), and mental health (MH) in women with PFRI. Methods This is a study protocol for a randomized controlled trial. A total of 182 participants are expected to participate in the study after satisfying the inclusion criteria. The participants will be randomized into either PEM or PFMT study groups. The demographic data of all the participants will be recorded. Each participant will be assessed for urine leakage, PFS, QoL, SF, and MH at baseline and subsequently, at four, eight and 12 weeks of intervention. Demographic parameters will be summarized using descriptive statistics. Continuous data will be computed for differences using inferential statistic of Analysis of variance, t-test and Man Whitney U as appropriate. All analyses will be performed using SPSS version 22.0 with probability set at 0.05 alpha level. Discussion It is hoped that the outcome of this study will determine the effect of the Paula exercise method on urine leakage, pelvic floor strength, quality of life, sexual function, and mental health among women with post-fistula-repair incontinence and also provide evidence for the use of the Paula method in urinary incontinence. Trial registration: Pan African Clinical Trials Registry (www.pactr.org), identifier PACTR201906515532827.

A Randomized, Controlled Trial of Fibrin Glue vs. Conventional Treatment for Anal Fistula

2002 ◽  
Vol 45 (12) ◽  
pp. 1608-1615 ◽  
Author(s):  
Ian Lindsey ◽  
M. M. Smilgin-Humphreys ◽  
Chris Cunningham ◽  
Neil J. M. Mortensen ◽  
Bruce D. George
Keyword(s):  
Randomized Controlled Trial ◽  
Fibrin Glue ◽  
Anal Fistula ◽  
Conventional Treatment ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Išangės fistulės kamščio metodo taikymas sudėtingai išangės fistulei gydyti

2010 ◽  
Vol 8 (4) ◽  
pp. 0-0
Author(s):  
Edgaras Palubinskas ◽  
Narimantas Evaldas Samalavičius ◽  
Lina Gudelytė
Keyword(s):  
Randomized Controlled Trial ◽  
Success Rate ◽  
Anal Fistula ◽  
Controlled Trial ◽  
Fistula In Ano ◽  
Randomized Controlled ◽  
Fistula Plug ◽  
Complex Fistula ◽  
Anal Fistula Plug ◽  
Vilnius University

Edgaras Palubinskas1, Narimantas Evaldas Samalavičius2, Lina Gudelytė1 1 Vilniaus universiteto Medicinos fakultetas, M. K. Čiurlionio g. 21, LT-03101 Vilnius2 Vilniaus universiteto Onkologijos instituto Chirurgijos klinika ir Vilniaus universiteto Medicinos fakulteto Vidaus ligų, šeimos medicinos ir onkologijos klinika,Santariškių g. 1, LT-08406 VilniusEl. paštas: [email protected] Tikslas: Tyrimo tikslas buvo įvertinti išangės fistulės kamščio (IFK) efektyvumą, gydant aukštas išangės fistules. Metodai: Į apžvalgą iš viso įtraukta 19 darbų iš 31, išspausdinto 2006–2010 m. Iš įtrauktųjų 8 yra retrospektyvinės studijos, 9 prospektyvinės, viena dvigubai akla randomizuota studija ir viena prospektyvinė nerandomizuota kontrolinė studija. Bendras į šias studijas įtrauktų ligonių, gydytų išangės fistulės kamščio metodu, skaičius yra 551. Rezultatai: Pooperacinio stebėjo laikas buvo nuo 3 iki 24 mėnesių. Gydymo išangės fistulės kamščiu sėkmingumas – nuo 15,6 % iki 88 %. Iš 551 IFK gydytų ligonių 300 (54,4 %) pasveiko. Kriptoglanduliarinės kilmės (K) fistulės buvo sėkmingai išgydytos 55,1 % atvejų, o įvairios kilmės (I) – 54,9 %. Neaptikome patikimo ryšio tarp sėkmingo gydymo rezultatų ir paciento lyties, amžiaus, fistulės ilgio ar kilmės. Išvados: Išangės fistulės kamščio metodas yra patikimas gydyti sudėtingas fistula-in-ano. Ateities tyrimai turėtų padėti aiškiau apibrėžti gydymo išangės fistulės kamščiu metodo vietą išangės fistulių chirurgijoje. Reikšminiai žodžiai: fistula-in-ano, išangės fistulės kamštis, ligos atkrytis, tiesiosios žarnos lopas. Anal fistula plug for the treatment of complex fistula-in-ano Edgaras Palubinskas1, Narimantas Evaldas Samalavičius2, Lina gudelytė1 1 Vilnius University Medical Faculty, M. K. Čiurlionio str. 21, LT-03101 Vilnius, Lithuania2 Vilnius University, Institute of Oncology, Clinic of Surgery,Santariškių str. 1, LT-08406 Vilnius, LithuaniaE-mail: [email protected] Purpose: The aim of the study was to evaluate the efficacy of the anal fistula plug (AFP) for the treatment of fistula-in-ano. Methods: A total of 31 studies, published since 2006 to 2010 were extracted and 19 of them were finally included in this systematic review. 8 were retrospective case series, 9 prospective studies, 1 prospective non-randomized controlled trial and 1 randomized controlled trial. In these 19 studies, a total of 551 patients were included, who were treated with anal fistula plug. Results: The follow-up period ranged from 3–24 months. The AFP procedure had a success rate ranging from 15.6–88 %. From 551 patients treated with AFP, 300 (54.4 %) were cured. The success rate in patients with cryptoglandular origin (K) was 55.1 % and the success rate in patients with fistulas of other origin was 54.9 %. We did not notice difference in success rate between age, gender, fistula anatomy and etiology. Conclusion: The anal fistula plug method is a reliable method in treat of complex fistula-in-ano. Future studies should help to clarify the place of anal fistula plug in anal fistula surgery. Key words: Fistula-in-ano, anal plug, recurrence, advancement flap.

scholarly journals Randomized Controlled Trial: Prophylactic Autologous Fascia Sling for Women at Risk of Urethral Incontinence after Obstetric Fistula Repair

2018 ◽  
Vol 13 (2) ◽  
Author(s):  
Rachel Pope ◽  
Andrew Browning ◽  
Ennet Chipungu ◽  
Jeredine George ◽  
Tammimu Mariatu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Obstetric Fistula ◽  
Controlled Trial ◽  
Safety Analysis ◽  
Fistula Repair ◽  
Symptom Index ◽  
Randomized Controlled ◽  
Continence Rate ◽  
Rectus Fascia

Aims: To compare sling types as anti-incontinence procedure for women with obstetric fistulas at high-risk for residual incontinence. Methods: This is a multiple-site randomized controlled trial comparing autologous fascia slings to pubococcygeal (PC) slings at time of fistula repair. Participants with a Goh type 3 or 4 vesico-vaginal fistula (urethral length <2.5 cm) with no prior repair were randomized to receive either a rectus fascia sling or a PC sling while undergoing fistula repair. Interviews were performed before surgery and at follow up including the Michigan incontinence symptom index (M-ISI) and the Incontinence quality of life tool (I-QOL). Safety analysis was performed after ten participants have been enrolled in each arm. Results: Eleven participants randomized to a PC sling and ten to a rectus sling. There was one repair breakdown in the PC group and three in the rectus group. Pad weights trended lower in the rectus group. QOL and MISI scores improved significantly for both groups. The study was terminated at safety analysis due to the number of breakdowns and difficulty of follow-up at one site. Conclusions: There was no superiority between slings. Randomization proved problematic given the vast heterogeneity between fistula injuries. When compared to slings placed after an initial VVF repair in the literature, continence rate with the prophylactic rectus fascia sling was improved. There is a need for an innovative prophylactic anti-incontinence technique that does not result in repair failure.

Treatment Fidelity Procedures for an Aphasia Intervention Within a Randomized Controlled Trial: Design, Feasibility, and Results

2020 ◽  
Vol 29 (1S) ◽  
pp. 412-424
Author(s):  
Elissa L. Conlon ◽  
Emily J. Braun ◽  
Edna M. Babbitt ◽  
Leora R. Cherney
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Treatment Protocol ◽  
Treatment Fidelity ◽  
Protocol Adherence ◽  
Study Condition ◽  
Randomized Controlled ◽  
Aphasia Therapy ◽  
Percent Accuracy ◽  
Over Time

Purpose This study reports on the treatment fidelity procedures implemented during a 5-year randomized controlled trial comparing intensive and distributed comprehensive aphasia therapy. Specifically, the results of 1 treatment, verb network strengthening treatment (VNeST), are examined. Method Eight participants were recruited for each of 7 consecutive cohorts for a total of 56 participants. Participants completed 60 hr of aphasia therapy, including 15 hr of VNeST. Two experienced speech-language pathologists delivered the treatment. To promote treatment fidelity, the study team developed a detailed manual of procedures and fidelity checklists, completed role plays to standardize treatment administration, and video-recorded all treatment sessions for review. To assess protocol adherence during treatment delivery, trained research assistants not involved in the treatment reviewed video recordings of a subset of randomly selected VNeST treatment sessions and completed the fidelity checklists. This process was completed for 32 participants representing 2 early cohorts and 2 later cohorts, which allowed for measurement of protocol adherence over time. Percent accuracy of protocol adherence was calculated across clinicians, cohorts, and study condition (intensive vs. distributed therapy). Results The fidelity procedures were sufficient to promote and verify a high level of adherence to the treatment protocol across clinicians, cohorts, and study condition. Conclusion Treatment fidelity strategies and monitoring are feasible when incorporated into the study design. Treatment fidelity monitoring should be completed at regular intervals during the course of a study to ensure that high levels of protocol adherence are maintained over time and across conditions.

Phonomotor Versus Semantic Feature Analysis Treatment for Anomia in 58 Persons With Aphasia: A Randomized Controlled Trial

2019 ◽  
Vol 62 (12) ◽  
pp. 4464-4482 ◽  
Author(s):  
Diane L. Kendall ◽  
Megan Oelke Moldestad ◽  
Wesley Allen ◽  
Janaki Torrence ◽  
Stephen E. Nadeau
Keyword(s):  
Randomized Controlled Trial ◽  
Response Latency ◽  
Controlled Trial ◽  
Semantic Knowledge ◽  
Semantic Feature ◽  
Feature Analysis ◽  
Group Differences ◽  
Randomized Controlled ◽  
Confrontation Naming ◽  
Semantic Feature Analysis

Purpose The ultimate goal of anomia treatment should be to achieve gains in exemplars trained in the therapy session, as well as generalization to untrained exemplars and contexts. The purpose of this study was to test the efficacy of phonomotor treatment, a treatment focusing on enhancement of phonological sequence knowledge, against semantic feature analysis (SFA), a lexical-semantic therapy that focuses on enhancement of semantic knowledge and is well known and commonly used to treat anomia in aphasia. Method In a between-groups randomized controlled trial, 58 persons with aphasia characterized by anomia and phonological dysfunction were randomized to receive 56–60 hr of intensively delivered treatment over 6 weeks with testing pretreatment, posttreatment, and 3 months posttreatment termination. Results There was no significant between-groups difference on the primary outcome measure (untrained nouns phonologically and semantically unrelated to each treatment) at 3 months posttreatment. Significant within-group immediately posttreatment acquisition effects for confrontation naming and response latency were observed for both groups. Treatment-specific generalization effects for confrontation naming were observed for both groups immediately and 3 months posttreatment; a significant decrease in response latency was observed at both time points for the SFA group only. Finally, significant within-group differences on the Comprehensive Aphasia Test–Disability Questionnaire ( Swinburn, Porter, & Howard, 2004 ) were observed both immediately and 3 months posttreatment for the SFA group, and significant within-group differences on the Functional Outcome Questionnaire ( Glueckauf et al., 2003 ) were found for both treatment groups 3 months posttreatment. Discussion Our results are consistent with those of prior studies that have shown that SFA treatment and phonomotor treatment generalize to untrained words that share features (semantic or phonological sequence, respectively) with the training set. However, they show that there is no significant generalization to untrained words that do not share semantic features or phonological sequence features.

Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial

2001 ◽  
Vol 26 (1) ◽  
pp. 67-71 ◽  
Author(s):  
S. A. Ahmadi-Abhari ◽  
S. Akhondzadeh ◽  
S. M. Assadi ◽  
O. L. Shabestari ◽  
Z. M. Farzanehgan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled
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