Synthesis and biological evaluation of novel biphenyl-furocoumarin derivatives as vasodilator agents

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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Synthesis and biological evaluation of Schiff bases and pyrazole derivatives derive from chalcones, (2E)1-(4-aminophenyl)-3-(2-furyl)prop-2-en-1-one

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.01.138 ◽

2020 ◽

Vol 12 (1) ◽

Keyword(s):

Schiff Bases ◽

Biological Evaluation ◽

Pyrazole Derivatives ◽

Synthesis And Biological Evaluation

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Faculty Opinions recommendation of Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1064759.517678 ◽

2007 ◽

Author(s):

Hugh Rosen

Keyword(s):

Biological Evaluation ◽

Receptor Agonists ◽

Sphingosine 1 Phosphate ◽

Subtype Selective ◽

Synthesis And Biological Evaluation ◽

Receptor Agonists And Antagonists

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Faculty Opinions recommendation of Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726271231.793520213 ◽

2016 ◽

Author(s):

Miles Congreve ◽

Mark Pickworth

Keyword(s):

G Protein ◽

Biological Evaluation ◽

Receptor Kinase ◽

G Protein Coupled Receptor ◽

Design Synthesis ◽

G Protein Coupled ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of Various New Substituted 1,3,4-oxadiazole-2-thiols

Revista de Chimie ◽

10.37358/rc.08.4.1795 ◽

2008 ◽

Vol 59 (4) ◽

Author(s):

Gabriela Laura Almajan ◽

Stefania Felicia Barbuceanu ◽

Ioana Saramet ◽

Mihaela Dinu ◽

Cristian Vasile Doicin ◽

...

Keyword(s):

Biological Activity ◽

Plant Growth ◽

1H Nmr ◽

Elemental Analysis ◽

13C Nmr ◽

Biological Evaluation ◽

Ethyl Chloroacetate ◽

Low Concentrations ◽

Synthesis And Biological Evaluation

5-[4-(4X-phenylsulfonyl)phenyl]-1,3,4-oxadiazole-2-thiols, X=H, Cl, Br, reacted with ethyl chloroacetate to give S-alkylated compounds. Aminomethylation of the thione form of oxadiazoles yielded N(3)-derivatives. All the products have been characterized by elemental analysis, IR, 1H-NMR and 13C-NMR. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak stimulatory activities at low concentrations.

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