Antibiotic resistance in wastewater, does the context matter? Poland and Portugal as a case study

2021 ◽  
pp. 1-23
Author(s):  
Ivone Vaz-Moreira ◽  
Monika Harnisz ◽  
Joana Abreu-Silva ◽  
Damian Rolbiecki ◽  
Ewa Korzeniewska ◽  
...  
Keyword(s):  
Antibiotic Resistance

Behavior of antibiotics and antibiotic resistance genes in eco-agricultural system: A case study

2016 ◽  
Vol 304 ◽  
pp. 18-25 ◽  
Author(s):  
Weixiao Cheng ◽  
Jianan Li ◽  
Ying Wu ◽  
Like Xu ◽  
Chao Su ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Resistance Genes ◽  
Antibiotic Resistance Genes ◽  
Agricultural System ◽  
System A

scholarly journals Spread of Antibiotic Resistance in Aquatic Environments: E. coli as a Case Study

Proceedings ◽  
2018 ◽  
Vol 2 (11) ◽  
pp. 693 ◽  
Author(s):  
Maria Adamantia Efstratiou ◽  
Marina Bountouni ◽  
Efthimios Kefalas
Keyword(s):  
Escherichia Coli ◽  
Drinking Water ◽  
Antibiotic Resistance ◽  
Rural Communities ◽  
Ground Water ◽  
Aquatic Environments ◽  
Multiple Resistance ◽  
E Coli ◽  
Of Greece

The aim of this study was to gather information on the spread of antibiotic resistance in Escherichia coli isolates from wells, boreholes and untreated drinking water in islands of Greece. We analyzed for antibiotic resistance 235 E. coli strains isolated from untreated drinking water of small rural communities, and ground water from 4 islands. Resistance was tested against Norfloxacin, Ciprofloxacin, Levofloxacin, Amoxicillin and Cefaclor. More than half (54.9%) were resistant to at least one of the antibiotics tested. Of these 26.3% showed multiple resistance (to two or more antibiotics). Strains from drinking water sources were overall more sensitive. Frequent resistance was observed for Amoxicillin (38.3%) and Levofloxacin (28.5%), low for Norfloxacin (5.5%).

scholarly journals Detection of Antimicrobial Resistance Using Proteomics and the Comprehensive Antibiotic Resistance Database: A Case Study

2020 ◽  
Vol 14 (4) ◽  
pp. 1800182 ◽  
Author(s):  
Chih‐yu Chen ◽  
Clifford G. Clark ◽  
Stacie Langner ◽  
David A. Boyd ◽  
Amrita Bharat ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Antimicrobial Resistance

scholarly journals Strategic Approach for Prioritising Local and Regional Sanitation Interventions for Reducing Global Antibiotic Resistance

Water ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 27 ◽  
Author(s):  
David Graham ◽  
Myra Giesen ◽  
Joshua Bunce
Keyword(s):  
Antibiotic Resistance ◽  
Antibiotic Use ◽  
Middle Income ◽  
Middle Income Countries ◽  
National Priority ◽  
Strategic Approach ◽  
Starting Point ◽  
Improved Sanitation ◽  
Intervention Costs

Globally increasing antibiotic resistance (AR) will only be reversed through a suite of multidisciplinary actions (One Health), including more prudent antibiotic use and improved sanitation on international scales. Relative to sanitation, advanced technologies exist that reduce AR in waste releases, but such technologies are expensive, and a strategic approach is needed to prioritize more affordable mitigation options, especially for Low- and Middle-Income Countries (LMICs). Such an approach is proposed here, which overlays the incremental cost of different sanitation options and their relative benefit in reducing AR, ultimately suggesting the “next-most-economic” options for different locations. When considering AR gene fate versus intervention costs, reducing open defecation (OD) and increasing decentralized secondary wastewater treatment, with condominial sewers, will probably have the greatest impact on reducing AR, for the least expense. However, the best option for a given country depends on the existing sewerage infrastructure. Using Southeast Asia as a case study and World Bank/WHO/UNICEF data, the approach suggests that Cambodia and East Timor should target reducing OD as a national priority. In contrast, increasing decentralized secondary treatment is well suited to Thailand, Vietnam and rural Malaysia. Our approach provides a science-informed starting point for decision-makers, for prioritising AR mitigation interventions; an approach that will evolve and refine as more data become available.

Scaling and Subjectification in an ESD Educational Project

2018 ◽  
Vol 12 (1) ◽  
pp. 28-46 ◽  
Author(s):  
Martin Mickelsson ◽  
Anna Danielsson
Keyword(s):  
Climate Change ◽  
Antibiotic Resistance ◽  
Learning Process ◽  
Educational Innovations ◽  
Subject Positions ◽  
Educational Project ◽  
The Subject ◽  
The Way

The aim of the article is to investigate, in the light of the emphasis laid on scaling by UNESCO (UNESCO, 2014a), how subjectification of those involved in educational innovations both enables and constricts scaling understood as a learning process. This is carried out through a case study of the Alforja Educativa, an educational project in Ecuador on antibiotic resistance (ABR). The ABR has been described as a sustainability challenge comparable to climate change. The way in which subjectification enables and constricts scaling as a learning process is analysed by drawing on educational scaling research and the article illustrates how the subject positions of those involved in scaling emerge as scaling subjects in transactional relationships, both with the sites where the educational project is to be scaled, and in relation to that, which will be scaled.

scholarly journals The rising impact of mathematical modelling in epidemiology: antibiotic resistance research as a case study

2007 ◽  
Vol 136 (3) ◽  
pp. 289-298 ◽  
Author(s):  
L. TEMIME ◽  
G. HEJBLUM ◽  
M. SETBON ◽  
A. J. VALLERON
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Mathematical Modelling ◽  
Citation Impact ◽  
Temporal Trends ◽  
Public Health Decision ◽  
Health Decision Making ◽  
Health Decision ◽  
Scientific Fields

SUMMARYMathematical modelling of infectious diseases has gradually become part of public health decision-making in recent years. However, the developing status of modelling in epidemiology and its relationship with other relevant scientific approaches have never been assessed quantitatively. Herein, using antibiotic resistance as a case study, 60 published models were analysed. Their interactions with other scientific fields are reported and their citation impact evaluated, as well as temporal trends. The yearly number of antibiotic resistance modelling publications increased significantly between 1990 and 2006. This rise cannot be explained by the surge of interest in resistance phenomena alone. Moreover, modelling articles are, on average, among the most frequently cited third of articles from the journal in which they were published. The results of this analysis, which might be applicable to other emerging public health problems, demonstrate the growing interest in mathematical modelling approaches to evaluate antibiotic resistance.

scholarly journals Peer-to-peer learning through research: a case study in delivering a healthcare message

2016 ◽  
Author(s):  
Sadaf Ilias ◽  
Jill Barber
Keyword(s):  
Antibiotic Resistance ◽  
Undergraduate Students ◽  
The Body ◽  
The Other ◽  
Learning Activity ◽  
Follow Up Study ◽  
Raising Awareness ◽  
Second Year

This case study describes a recent learning activity involving pharmacy undergraduate students in which a final (fourth) year student trained 21 second year students to administer questionnaires about antibiotic resistance to over 700 student users of a large university building. The aim was to raise awareness of the problem of antibiotic resistance.  The second year students were also trained to correct any misapprehensions held by the questionnaire participants about antibiotic resistance, and to encourage them to become "Antibiotic Guardians". Finally the 22 students analysed the data to give a picture of what the other students understood about antibiotic resistance.  Peer-assisted learning therefore cascaded from a single fourth year student to 21 second year students and then to 700 students from various disciplines and year groups.  The first stage of the cascade was evaluated and the 21 second year students overwhelmingly believed that their knowledge of antibiotic resistance was enhanced.  A follow-up study using the same questionnaire will be used to determine whether the exercise was effective in raising awareness of antibiotic resistance among the body of students surveyed.

Novel discovery of Extended Spectrum β-lactamase (ESBL) Pluralibacter gergoviae in acute urinary tract infection and urolithiasis

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S128-S128
Author(s):  
E Coate ◽  
T Merchen ◽  
R Cybulski ◽  
R Collier ◽  
P Mc Gann ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Antibiotic Resistance ◽  
Platelet Rich Plasma ◽  
American Woman ◽  
Antibiotic Resistance Genes ◽  
Illumina Miseq ◽  
Lessons Learned ◽  
Resistant Organism ◽  
Walter Reed Army Institute

Abstract Introduction/Objective This case study describes the diagnosis, treatment, whole genome sequencing (WGS) and antibiotic resistance characterization from the ESBL-producing Pluralibacter gergoviae, a multi-drug resistant organism (MDRO) with a previously-documented presence in foodstuffs and cosmetics. Methods/Case Report A 39-year-old Hispanic American woman was admitted to the emergency department (ED) for fever, suprapubic tenderness, and pyuria. Three days prior to admission, patient underwent elective bilateral lithotripsy for retained nephrolithiasis. Seven days prior to ED admission, patient had an “Orgasm Shot” (O-Shot) which consists of platelet rich plasma that is drawn from the patient and injected into her vulvar area and around her clitoris to increase stimulation potential during orgasm. The patient was started on broad spectrum antibiotics, receiving Vancomycin and Ceftriaxone 1 gram 1 gram IV every 12 hours, intravenously. Urine cultures yielded two organisms, including a lactose fermenting as well as a non-lactose fermenting Gram negative rod. Mass spectrometry-based identification was successful in identifying the non-lactose fermenting colony as Pseudomonas aeruginosa, which also identified from a blood culture collected from the patient upon presentation to the ED. The lactose fermenting colony resulted in no identification by mass spectrometry but was identified using biochemical methods as Pluralibacter gergoviae, a recently-reclassified taxonomy previously identified as Enterobacter gergoviae. The P. gergoviae isolate was submitted to the Multidrug-Resistant Organism Repository (MRSN) at Walter Reed Army Institute of Research (WARIR) for WGS on Illumina Miseq. Sequencing and phenotypic/ genotypic data on isolate confirmed this as an ESBL P. gergoviae organism. Results (if a Case Study enter NA) NA Conclusion Summary data on possible epidemiological associations, antibiotic susceptibility testing, antibiotic resistance genes identified, and information on the antibiotic resistance plasmids will be presented. These findings from the WGS data, antibiotic susceptibilities will provide a lessons-learned for other clinical microbiology labs on how to identify unusual organisms such as P. gergoviae.

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