Concentration of vaginal and systemic cytokines obtained early in pregnancy and their impact on preterm birth

Background: This systematic review and meta-analysis summarizes the evidence for the association between endometriosis and adverse pregnancy outcome, including gestational hypertension, pre-eclampsia, low birth weight, and small for gestational age, preterm birth, placenta previa, placental abruption, cesarean section, stillbirth, postpartum hemorrhage, spontaneous hemoperitoneum in pregnancy, and spontaneous bowel perforation in pregnancy. Methods: We performed the literature review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), by searches in PubMed and EMBASE, until 1 November 2020 (PROSPERO ID CRD42020213999). We included peer-reviewed observational cohort studies and case-control studies and scored them according to the Newcastle–Ottawa Scale, to assess the risk of bias and confounding. Results: 39 studies were included. Women with endometriosis had an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth, compared to women without endometriosis. These results remained unchanged in sub-analyses, including studies on spontaneous pregnancies only. Spontaneous hemoperitoneum in pregnancy and bowel perforation seemed to be associated with endometriosis; however, the studies were few and did not meet the inclusion criteria. Conclusions: The literature shows that endometriosis is associated with an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth.

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Article Commentary: Activity in Pregnancy for Patients with a History of Preterm Birth

Clinical Medicine Insights Women s Health ◽

10.4137/cmwh.s34684 ◽

2016 ◽

Vol 9s1 ◽

pp. CMWH.S34684 ◽

Cited By ~ 1

Author(s):

Nichelle Satterfield ◽

Edward R. Newton ◽

Linda E. May

Keyword(s):

Preterm Birth ◽

History Of ◽

In Pregnancy

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Microbial pathogens in urogenital infection in pregnant women

Journal of microbiology epidemiology immunobiology ◽

10.36233/0372-9311-2019-6-13-20 ◽

2019 ◽

pp. 13-20

Author(s):

A. V. Karaulov ◽

M. S. Afanasiev ◽

Yu. V. Nesvizhsky ◽

S. S. Afanasiev ◽

E. A. Voropaeva ◽

...

Keyword(s):

Preterm Birth ◽

Pregnant Women ◽

Pregnancy Termination ◽

Clinical Manifestations ◽

Microbial Pathogens ◽

Enzyme Linked Immunosorbent Assay ◽

Cervical Canal ◽

Type I ◽

Urogenital Infection ◽

In Pregnancy

Introduction. Chronic and latent infections are often activated during pregnancy.Aim - to asses the pathogenetic role of microbial pathogens in urogenital tract infection (UTI) in pregnant women.Materials and methods. 89 pregnant women underwent general clinical examination, examination of smears from urethra, vagina, cervical canal; bacteriological analysis of vaginal contents; enzyme-linked immunosorbent assay, polymerase chain reaction and determination of specific antibodies for verification of herpes simplex virus (HSV) type I and II, cytomegalovirus (CMV), Epstein-Barr (EBV) and UTI pathogens in pregnant women in blood and mucosal scrapes.Results. Prevalence of Herpesviridae was revealed (90-100% -EBV, HSV type I and II, CMV); in 41% of cases - bacterial pathogens, in 57% of cases - Mycoplasma, Ureaplasma.Discussion. In preterm birth and pregnancy termination mycoplasma and ureaplasma were more often revealed, and in pregnancy termination - association of HSV type I and II in comparison with urgent birth; in the last equally often - HSV type I and association of HSV type I and II; in urgent birth (infection) more often - HSV type I, than association of HSV type I and II; in preterm birth more often - HSV type I, than the association of HSV types I and II, and less often than combination of HSV type I and association of HSV types I and II in pregnancy termination; in the last, the association of HSV types I and II is more common than HSV type I. Increase of TLRs genes expression levels depends on HSV type I less than from association of HSV types I and II, less than from combination of HSV type I and association of HSV types I and II (it determines the clinical manifestations of genital herpes).Conclusion. Microbial pathogens determine the character of pregnancy course, and HSV types I and II- are the triggers of the infectious process, prognosing its course.

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PENINGKATAN KESEHATAN PERIODONTAL IBU HAMIL DALAM UPAYA MENGURANGI RESIKO BAYI DENGAN BERAT BADAN LAHIR RENDAH

Jurnal Layanan Masyarakat (Journal of Public Services) ◽

10.20473/jlm.v4i2.2020.275-281 ◽

2020 ◽

Vol 4 (2) ◽

pp. 275

Author(s):

I KOMANG EVAN WIJAKSANA ◽

Lambang Bargowo ◽

Shafira Kurnia Supandi

Keyword(s):

Preterm Birth ◽

Pregnant Women ◽

Community Service ◽

Periodontal Diseases ◽

Oral Care ◽

Pregnancy Rates ◽

Dental Visit ◽

Periodontal Tissue ◽

Knowledge And Skills ◽

In Pregnancy

During the Covid-19 pandemic, there was an increase in pregnancy rates in East Java. Besides efforts to suppress pregnancy rates, it is also necessary to ensure the health of the mother and fetus in order to be born healthy. The prevalence of periodontal diseases in pregnant women is high, while the dental visit of pregnant women is low. Periodontal disease is one of the risk factors of preterm birth as well as low-birth-weight (LBW) infants. In this community service, socialization held through lecture methods, QnA, discussion and self-practice procedures to maintain oral health procedures. The goal is to improve pregnant women's knowledge of the importance of dental and oral care, especially periodontal tissue during pregnancy and enhance skills of pregnant women in detecting early symptoms of periodontal diseases and to perform oral dental care independently at home. The knowledge and skills of pregnant women can be improved during this community service. By healthy periodontal tissue and teeth, it is expected that the risk of LBW infants and also preterm birth can be decreased.abstrakSelama masa pandemi Covid-19, terjadi peningkatan tingkat kehamilan di Jawa Timur. Selain usaha menekan tingkat kehamilan, perlu juga dipastikan kesehatan ibu dan janin agar lahir dengan sehat. Prevalensi kelainan periodontal pada ibu hamil tinggi sementara kunjungan ibu hamil ke dokter gigi rendah. Penyakit periodontal merupakan salah satu faktor resiko bayi lahir prematur dan juga berat badan lahir rendah (BBLR). Dalam pengabdian masyarakat ini dilakukan sosialisasi melalui metode ceramah, tanya jawab, diskusi dan praktek mandiri prosedur menjaga kesehatan rongga mulut. Tujuannya adalah meningkatkan pengetahuan ibu hamil mengenai pentingnya perawatan gigi dan mulut khususnya jaringan periodontal selama kehamilan dan meningkatnya ketrampilan ibu hamil dalam mendeteksi gejala awal kelainan periodontal dan cara melakukan perawatan gigi mulut mandiri di rumah. Pada pengabdian masyarakat ini pengetahuan dan ketrampilan ibu hamil dapat ditingkatkan. dengan jaringan periodontal dan gigi serta rongga mulut yang sehat, diharapkan resiko BBLR maupun kelahiran prematur dapat diturunkan.

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RELATIONSHIP OF MATERNAL VITAMIN B12 STATUS IN PREGNANCY WITH PRETERM BIRTH AND MATERNAL HEALTH RISKS

International Medical Journal ◽

10.37436/2308-5274-2020-2-7 ◽

2020 ◽

pp. 32-38

Author(s):

VICTORIA LAZAROVA SPASOVA ◽

LILIA IVANOVA KOLEVA ◽

MARIETA ANTONOVA POPOVA ◽

VALENTINA BOYANOVA PETKOVA ◽

MILEN VENTZISLAVOV DIMITROV

Keyword(s):

Preterm Birth ◽

Vitamin B12 ◽

Pregnant Women ◽

Serum Vitamin ◽

Vitamin B12 Deficiency ◽

Inverse Association ◽

Maternal Vitamin ◽

B12 Deficiency ◽

The Impact ◽

In Pregnancy

Vitamin B12 is known to be vital for cell growth and population during pregnancy. This retrospective and prospective case−control study was aimed to disclose a health risk for pregnant women with vitamin B12 deficiency, as well as the one of the preterm birth. The main tasks set and performed in this research were as follows: to compare the obstetrics anamnesis between the women who gave birth on term and women who gave birth before term; to find the prevalence of vitamin B12 insufficiency in pregnancy; to determine its association with preterm birth and low birth weight; to examine its association with spontaneous abortions, and to investigate its relationship with obesity and hemoglobin levels in pregnant women. The conducted investigation involved 107 women who gave birth before the 37th week of gestation and 101 women who gave birth after the 37th week of gestation at the outpatient clinic of the University Hospital "Maichin Dom" in Bulgaria. Our study revealed a correlation between maternal vitamin B12 deficiency, overweight and low hemoglobin level. Our results showed no significant correlation between serum vitamin B12 level and the risk of preterm birth. However, we found an inverse association between vitamin B12 level and overweight before pregnancy and at the time of giving birth. As well there was confirmed the strong connection between meat consumption and vitamin B12 level. The paper emphasizes that the deficiency of the vitamin occurs most likely in the women with inadequate diets. Such a deficiency is actually confirmed to have serious health consequences for pregnant women and their offspring. Therefore further profound and numerous studies should be performed to properly assess the correlation between vitamin B12 and preterm birth, as well as to understand better the impact of vitamin B12 over pregnant women. Key words: vitamin B12, preterm birth, pregnancy, overweight, hemoglobin.

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