Two new eudesmane sesquiterpene glucosides from the aerial parts of Artemisia vulgaris

Essential Oil from wild growing Artemisia vulgaris L. originating in Erie, Pennsylvania was obtained by hydrodistillation of the aerial parts of the plant. Gas chromatographic-mass spectral analysis was used to identify the major volatiles present. Up to 22 components were detected in the essential oils. Germacrene D (25%), Caryophyllene (20%), α-Zingiberene (15%) and Borneol (11%) represent the major components of leaf oil, while the buds were rich in 1,8-Cineole (32%), Camphor (16%), Borneol (9%), and Caryophyllene (5%). trans-2-Hexenal was also detected in the aerial parts of the plant. α-Zingiberene and trans-2-Hexenal have not been previously reported for Artemisia vulgaris L. The major analytes are compared to those from Artemisia vulgaris L, originating outside of the United States.

Download Full-text

Evaluation of antioxidant, antimicrobial and cytotoxic potential in Artemisia vulgaris L.

Revista Romana de Medicina de Laborator ◽

10.2478/rrlm-2018-0020 ◽

2018 ◽

Vol 26 (4) ◽

pp. 431-441 ◽

Cited By ~ 1

Author(s):

Asad Hamad ◽

Muhammad Arfan ◽

Shujaat Ali Khan ◽

Nighat Fatima ◽

Arshad Mehmood Abbasi ◽

...

Keyword(s):

Micrococcus Luteus ◽

Cytotoxic Activities ◽

Artemisia Vulgaris ◽

Bacterial Strains ◽

Survival Percentage ◽

Aerial Parts ◽

Total Antioxidant ◽

Total Flavonoids Content ◽

Ancient Times ◽

Dpph Scavenging

Abstract Artemisia vulgaris L. (Mugwort or Afsantin) has been used to treat various diseases since ancient times by the inhabitants of Himalayan region-Pakistan. Methanolic fractions (HA1-HA9) obtained from the aerial parts of A. vulgaris were evaluated for their antioxidant, antimicrobial and brine shrimp cytotoxic activities. Fraction HA8 showed substantial phenolics content with value of 26.29±1.4μgEQ/mg and DPPH scavenging (82.84±3.01%). Conversely, total flavonoids content of 7.32±0.07μgEQ/mg was determined in HA1 fraction. Fraction HA1 also showed significant cytotoxic effect with the value LD50 of 144.94μg/mL. Fractions HA7 and HA9 depicted maximum total antioxidant activity and ferric ion reduction (96.25±3.29 and AAE/mg and 176.91±8, respectively). All fractions showed encouraging results against bacterial strains Bordetella bronchiseptica and Micrococcus luteus, while HA2 fraction showed the highest percentage inhibition Mucor species with zone of inhibition of 13.25±0.35mm. A total of 7 fractions showed significant antileishmanial activity with survival percentage ranging 0.00 to 19. To sum up, results of the current study indicated that the plant can be further explored for isolation of antileishmanial and antimicrobial compounds, which could be used for drug development.

Download Full-text

Phytochemical Screening, GC-MS Analysis and Biological Activities of Extracts of Artemisia vulgaris Linn.

Amrit Research Journal ◽

10.3126/arj.v2i01.40743 ◽

2021 ◽

Vol 2 (01) ◽

pp. 83-92

Author(s):

Rashma Chaudhary ◽

Binita Maharjan ◽

Samjhana Bharati ◽

Timila Shrestha ◽

Pawan Kumar Mishra ◽

...

Keyword(s):

Biological Activities ◽

Chloroform Extract ◽

Diffusion Method ◽

Artemisia Vulgaris ◽

Dry Extract ◽

Aerial Parts ◽

Ms Analysis ◽

Successive Extraction ◽

Ic50 Value ◽

Gallic Acid Equivalent

The aerial parts of Artemisia vulgaris were subjected for successive extraction in solvents methanol, hexane and chloroform, respectively, and compounds present in extract were analysed by GC-MS analysis 12 diﬀerent compounds were found in chloroform extract in which Germacrene was found most abundantly (33.84%). Chloroform extract showed strong antibacterial activity, which was examined against 6 bacteria using the disc diﬀusion method. The IC50 value of chloroform extract accounted for 1.50 mg/mL. The TPC content of the extract was found to be 87.75 mg gallic acid equivalent/g of dry extract, whereas TFC content was found to be 47.25 mg quercetin equivalent/g of dry extract and exhibited LC50 value of 0.18 mg/mL.

Download Full-text

Anti-inflammatory Activity of Aqueous-Ethanolic Extract of Aerial Parts of Artemisia vulgaris Linn. in Spargue Dawley Rats

Herbal Drugs as Therapeutic Agents ◽

10.1201/b17334-20 ◽

2014 ◽

pp. 165-170

Keyword(s):

Ethanolic Extract ◽

Inflammatory Activity ◽

Artemisia Vulgaris ◽

Aerial Parts ◽

Aqueous Ethanolic Extract ◽

Anti Inflammatory

Download Full-text

Compositional Variability and Toxic Activity of Mugwort (Artemisia vulgaris) Essential Oils

Natural Product Communications ◽

10.1177/1934578x1601100942 ◽

2016 ◽

Vol 11 (9) ◽

pp. 1934578X1601100 ◽

Cited By ~ 2

Author(s):

Asta Judzentiene ◽

Rasa Garjonyte

Keyword(s):

Essential Oils ◽

Brine Shrimp ◽

Artemisia Vulgaris ◽

Wild Populations ◽

Toxic Activity ◽

Aerial Parts ◽

Germacrene D ◽

Compositional Variability ◽

First Time

The compositional variability of the essential oils of aerial parts of mugwort ( Artemisia vulgaris L.), collected from fifteen wild populations in Lithuania is detailed. The most predominant components were davanones (13.8-45.5%, six oils), germacrene D (9.1-30.5%, four oils), 1,8-cineole (16.4%, one oil), camphor (18.9%, one oil), trans-thujone (8.9 and 10.9%, two oils) and cis-chrysanthenyl acetate (10.4%, one oil). To the best of our knowledge, the davanone chemotype for A. vulgaris oils is described for the first time. The toxicity of the mugwort essential oils was determined using brine shrimp ( Artemia sp.) assay. LC50 values (10.3-23.1 μg/mL) obtained for the oils after 24 h of exposure revealed that the oils containing appreciable amounts of germacrene D, 1,8-cineole, camphor and davanone were notably toxic.

Download Full-text