Antiglycation activity of β-glucogallin from Asparagus racemosus

2022 ◽  
pp. 1-7
Author(s):  
Shadab Ahmad ◽  
Alka Raj Pandey ◽  
Suriya Pratap Singh ◽  
Sushmita Singh ◽  
Koneni V. Sashidhara ◽  
...  
Keyword(s):  
Pharmatutor ◽  
2018 ◽  
Vol 6 (12) ◽  
pp. 46
Author(s):  
Ali MS ◽  
Mukherjee S ◽  
Roy D ◽  
Pal G ◽  
Makar S

Author(s):  
Adithya J ◽  
Bhagyalakshmi Nair ◽  
Aishwarya S ◽  
Lekshmi R. Nath

: SARS-CoV 2 is a novel virus strain of Coronavirus, reported in China in late December 2019. Its highly contagious nature in humans has prompted WHO to designate the ongoing pandemic as a Public Health Emergency of International Concern. At this moment, there is no specific treatment and the therapeutic strategies to deal with the infection are only supportive, and prevention aimed at reducing community transmission. A permanent solution for the pandemic, which has brought the world economy to the edge of collapse, is the need of the hour. This situation has brought intense research in traditional systems of medicine. Indian Traditional System, Ayurveda has a clear concept of the cause and treatment of pandemics. Through this review, information on the potential antiviral traditional medicines along with their immunomodulatory pathways is discussed. We have covered the seven most important Indian traditional plants with antiviral properties :Withaniasomnifera (L.) Dunal(family: Solanaceae),Tinosporacordifolia(Thunb.)Miers (family:Menispermaceae),Phyllanthusemblica L.(family:Euphorbiaceae),Asparagus racemosus L.(family:Liliaceae), Glycyrrhizaglabra L.(family:Fabaceae), Ocimum sanctum L.(family:Lamiaceae) and Azadirachta indica A.Juss(family:Meliaceae)in this review. An attempt is also made to bring into limelight the importance of dietary polyphenol, Quercetin which is a potential drug candidate in the making against the SARS-CoV2 virus.


Author(s):  
Maryam Azimi ◽  
Mohammad Javad Zahedi

Introduction: According to Rome IV, functional dyspepsia is diagnosed with presence of dyspepsia in the absence of organic or metabolic causes. FD caused by several factors such as impaired gastric accommodation and hypersensitivity to gastric distention. Several studies have reported effectiveness of herbal medicine on FD. This article, thus, reviews Persian herbal medicine in FD. Method: Electronic databases including Pubmed, Scopus, Cochrain, Embase, Web of science and Ovid were searched so as to find clinical articles related to dyspepsia and herbal medicine by July 2019. Our search strategies were traditional medicine, complementary and alternative medicine, herb, plant, and dyspepsia. We excluded all articles except Persian clinical trials. Results: We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like Asparagus racemosus, Brassica oleracea, Cynara scolymus, Ocimum basilicum, Mentha longifolia, Mentha pulegium, Mentha piperata, Pimpinella anisum, Nigella sativa, Mastic gum, Curcuma longa, Pistatio atlantica, Glycyrrhiza glabra, Solanum tuberosum and Zingiber officinale and compound remedies of Rosa damascene & Crocus sativus, Trachyspermum copticom & Apium graveolence, Carum carvi & Mentha pipperata, Gingiber officinalis & Cynara scolymus are effective in functional dyspepsia. Conclusion: Many people use herbal and traditional remedies for treatment of disorders such as gastrointestinal disordersو , especially in Asian countries. Several studies reported the efficacy of herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD.


2021 ◽  
Vol 145 ◽  
pp. 105013
Author(s):  
Shreyasi Majumdar ◽  
Smriti Gupta ◽  
Santosh Kumar Prajapati ◽  
Sairam Krishnamurthy
Keyword(s):  

2018 ◽  
Vol 8 (1) ◽  
pp. 32-44 ◽  
Author(s):  
Akshay K. Singh ◽  
Anjali Srivastava ◽  
Vivek Kumar ◽  
Karunakar Singh

2014 ◽  
Vol 97 (6) ◽  
pp. 1497-1502 ◽  
Author(s):  
Dada Patil ◽  
Manish Gautam ◽  
Sunil Gairola ◽  
Suresh Jadhav ◽  
Bhushan Patwardhan

Abstract Asparagus racemosus (AR) is a popular botanical present in several Ayurvedic medicines and nutritional and dietary supplements with immunomodulatory, galactogogue, and anticancer activity. A steroidal saponin known as shatavarin IV is one of the active constituents of AR. A new, selective, and rapid HPLC/MS/MS method has been developed and validated for quantitative estimation of shatavarin IV in crude, processed, and marketed samples of AR. The analytes were separated on a Luna C18 column using simple isocratic elution with water (0.1% acetic acid)–acetonitrile (0.1% acetic acid; 70 + 30, v/v) at a flow rate of 0.8 mL/min. The analytes were detected by electrospray ionization (ESI)-MS/MS and quantified using multiple reaction monitoring techniques in the positive ion mode. The method showed excellent linearity (r2 > 0.998) over the concentration range of 7.5 to 254 ng/mL with LOD of 2.5 ng/mL. Precision (RSD) and accuracy (recovery) were found in the ranges of 2.00 to 5.15 and 102 to 110%, respectively. The validated HPLC/ESI-MS/MS method was successfully applied to the quantification of shatavarin IV in crude, processed, and marketed (single or multiherb) AR samples. Therefore, this method could be used for QC and standardization of pharmaceutical or nutritional products containing AR.


Author(s):  
Monika D. Bhalodiya ◽  
Jayant R. Chavda ◽  
Nilesh K Patel ◽  
Ajay I. Patel ◽  
Ravi A. Manek

This study is aimed to evaluate extraction capacity of different solvents through determining total phenolic content, total flavonoid content, total saponin content, and an antioxidant assay of different solvent extracts (toluene, dichloromethane, chloroform, ethyl acetate, ethanol, methanol, water, 60% aqueous methanol, 60% aqueous ethanol and 60% aqueous acetone) of Asparagus racemosus (A. racemosus) root. The 60% aqueous methanol shows the highest extracting yield, in contrast, toluene shows the lowest yield. Highest total phenolic content (220.8±0.74mg GAE/g), total flavonoid content (219.3±0.64mg QCE/g), total tannin content (108.4±0.88mg GAE/g) were found from acetone extract. The methanol extract showed the highest saponin content (579.4±2.85mg ESE/g). Antioxidant potential determines by using various in vitro methodologies such as DPPH, FRAP, and ABTS assay. The lowest IC50 value was found in acetone extract and thus it exhibited the highest antioxidant activity. The highest correlation was found between phenolic content and the antioxidant assay. It seems that phenolic contents are responsible for free radicle scavenging activity. From the observation, it concluded that acetone extract rich with polyphenolic content and methanol extract shows the highest amount of saponin content.


2019 ◽  
Vol 38 (03) ◽  
Author(s):  
Birhanu Tsegaw ◽  
Rita Singh Majumdar

Milk is produced by the mammary gland of mammals to feed their young ones. Milk is an important nutrient-rich beverage that benefits our health. This article aims to study the effect of Asparagus racemosus root powder on milk yield and milk composition. The experiment was performed to determine the milk yield and milk protein, fat, total milk solid, and milk acidity after using Asparagus racemosus as a food supplement. The animals were selected based on purposive sampling to select lactate buffalo to avoid or reduced the error. During the experiment, animals fed in three phases; control, treatment, and the residual phase. In control phase animal diet normal ration, whereas in the treatment phase, a buffalo was diet 120 gram of Asparagus racemosus root powder in addition to its normal diet per buffalo per day. While in the residual phase, the animal was diet only normal ration. Each phase has been 5 days. The Milk collected from lactating buffalo in three phases; control, treatment, and the residual period. Each period has been five day. We also measured milk yield per day per buffalo. About 50 ml of milk was collected from each five buffalo every morning for 15 days. The data was analyzed through one way ANOVA and T-test using the procedure of statistical software. The result indicates that the diet was statistically significant effecting on milk yield at 5% (0.0196), protein at 1% (0.0113) and fat at 1% (0.0007) while the insignificant effect on milk acidity p >30 (0.3909) and total solid p >80 (0.8904). Therefore, feeding Asparagus racemosus, positively affects milk yield and milk protein and milk fat content.


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