Metabolic Syndrome Components and Leukocyte Telomere Length in Patients with Major Depressive Disorder

Author(s):  
Yu-Chi Huang ◽  
Pao-Yen Lin ◽  
Yu Lee ◽  
Chun-Yi Lee ◽  
Yi-Ching Lo ◽  
...  
Author(s):  
Petra Hoen ◽  
Peter de Jonge ◽  
Beeya Na ◽  
Ramin Farzaneh-Far ◽  
Elissa Epel ◽  
...  

Background Shortened telomere length has been associated with mortality in patients with coronary heart disease (CHD) and is considered an emerging marker of biological age. Whether short telomere length is associated with depression in patients with CHD has not been evaluated. Methods In a cross-sectional study of 952 outpatients with stable CHD, we ascertained the presence of major depressive disorder using the Computerized Diagnostic Interview Schedule. Relative mean telomere length was measured from leukocyte DNA using a quantitative polymerase chain reaction assay. We examined the association between depression and leukocyte telomere length using linear and logistic regression models. Results Of the 952 participants, 206 (22%) had current (past month) depression. Patients with depression had lower mean ± SE telomere length than those without depression ( Table ). Likewise, patients with MDD had a 70% greater odds of having telomere length in the lowest vs. highest quartile (adjusted OR 1.70. 95% CI, 1.05-2.76; p=0.03). Conclusion Major depressive disorder is associated with reduced leukocyte telomere length in patients with stable CHD. The potential mechanisms underlying this association deserve further study. Mean +/- SE telomere length by presence of major depressive disorder Adjusted for Current major depression N=206 No current major depression N=746 P value age, sex 0.86±0.02 0.90±0.1 .02 age, sex, diabetes, BMI, smoking 0.86±0.02 0.89±0.01 .04 age, sex, diabetes, BMI, smoking, LVEF, statin use 0.85±0.02 0.89±0.01 .03


2019 ◽  
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Claudia Pisanu ◽  
Evangelia Eirini Tsermpini ◽  
Maria Skokou ◽  
Zoe Kordou ◽  
Philippos Gourzis ◽  
...  

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F. Saverio Bersani ◽  
Synthia H. Mellon ◽  
Elissa S. Epel ◽  
Victor I. Reus ◽  
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Vol 90 ◽  
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Eric Bui ◽  
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Vol 92 ◽  
pp. 119-123 ◽  
Author(s):  
Fernanda Pedrotti Moreira ◽  
Karen Jansen ◽  
Taiane de Azevedo Cardoso ◽  
Thaíse Campos Mondin ◽  
Pedro Vieira da Silva Magalhães ◽  
...  

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Vol 58 ◽  
pp. 9-22 ◽  
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Zandra E. Walton ◽  
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