Efficiency comparison of analysis methods for recurrent event and time-to-first event endpoints in presence of terminal events – application to clinical trials in chronic heart failure

2021 ◽  
pp. 1-29
Author(s):  
Arno Fritsch ◽  
Patrick Schlömer ◽  
Franco Mendolia ◽  
Tobias Mütze ◽  
Antje Jahn-Eimermacher ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Chronic Heart Failure ◽  
Recurrent Event ◽  
Analysis Methods ◽  
Terminal Events ◽  
Efficiency Comparison

scholarly journals Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes?

2021 ◽  
Vol 7 ◽  
Author(s):  
Wilson Matthew Raffaello ◽  
Joshua Henrina ◽  
Ian Huang ◽  
Michael Anthonius Lim ◽  
Leonardo Paskah Suciadi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Chronic Heart Failure ◽  
Poor Prognosis ◽  
Clinical Characteristics ◽  
De Novo ◽  
Heart Failure Patients ◽  
Treat Heart Failure ◽  
Patients With Heart Failure ◽  
New Strategies

Heart failure is currently one of the leading causes of morbidity and mortality. Patients with heart failure often present with acute symptoms and may have a poor prognosis. Recent evidence shows differences in clinical characteristics and outcomes between de novo heart failure (DNHF) and acute decompensated chronic heart failure (ADCHF). Based on a better understanding of the distinct pathophysiology of these two conditions, new strategies may be considered to treat heart failure patients and improve outcomes. In this review, the authors elaborate distinctions regarding the clinical characteristics and outcomes of DNHF and ADCHF and their respective pathophysiology. Future clinical trials of therapies should address the potentially different phenotypes between DNHF and ADCHF if meaningful discoveries are to be made.

scholarly journals Erratum to: Beta-Blockers and Ivabradine in Chronic Heart Failure: From Clinical Trials to Clinical Practice

2014 ◽  
Vol 14 (4) ◽  
pp. 333-333
Author(s):  
Antonino Di Franco ◽  
Filippo M. Sarullo ◽  
Ylenia Salerno ◽  
Stefano Figliozzi ◽  
Rossella Parrinello ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Clinical Practice ◽  
Chronic Heart Failure ◽  
Beta Blockers

Recognizing Worsening Chronic Heart Failure as an Entity and an End Point in Clinical Trials

JAMA ◽  
2014 ◽  
Vol 312 (8) ◽  
pp. 789 ◽  
Author(s):  
Javed Butler ◽  
Eugene Braunwald ◽  
Mihai Gheorghiade
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Chronic Heart Failure ◽  
End Point

Heart failure

2010 ◽  
pp. 3-28
Author(s):  
Juan Carlos Kaski
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Chronic Heart Failure ◽  
Systolic Function ◽  
Diastolic Heart Failure ◽  
Systolic Heart Failure ◽  
The Body ◽  
Pharmacological Management ◽  
Reduced Ejection Fraction ◽  
Structural Abnormalities

Introduction 4 Chronic heart failure with reduced LVEF (systolic heart failure) 6 Pharmacological management of chronic heart failure 8 Non-pharmacological management of chronic heart failure 18 Chronic heart failure with preserved LVEF (diastolic heart failure) 20 Acute heart failure 22 Clinical trials 26 Heart failure (HF) is a complex condition that results from cardiac functional and/or structural abnormalities that affect the ability of the heart to pump blood, and is often defined as the inability of the heart to adequately perfuse the organs of the body. Symptoms of HF vary depending on several factors but the most common manifestations of HF are dyspnoea and fatigue. Of importance, HF is not necessarily associated with a reduced ejection fraction (EF) (systolic HF), as up to 50% of cases occur in the presence of a preserved systolic function (diastolic dysfunction)....

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