scholarly journals Exposure hazards of oxidative stress in environmental pollutants and application of plant antioxidants

2021 ◽  
Vol 781 (5) ◽  
pp. 052031
Author(s):  
Changlei Li ◽  
Xiaoqing Chen ◽  
Hui Ling Yi ◽  
Baomiao Ma
Keyword(s):  
Oxidative Stress ◽  
Environmental Pollutants ◽  
Plant Antioxidants

scholarly journals Cardiovascular Effects of PCB 126 (3,3’,4,4’,5-Pentachlorobiphenyl) in Zebrafish Embryos and Impact of Co-Exposure to Redox Modulating Chemicals

2019 ◽  
Vol 20 (5) ◽  
pp. 1065 ◽  
Author(s):  
Elisabet Teixidó ◽  
Marta Barenys ◽  
Ester Piqué ◽  
Joan Llobet ◽  
Jesús Gómez-Catalán
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Environmental Pollutants ◽  
Cardiovascular Effects ◽  
Zebrafish Embryos ◽  
Oxidative Potential ◽  
Antioxidant Genes ◽  
Aryl Hydrocarbon ◽  
Low Concentrations ◽  
Pericardial Edema

The developing cardiovascular system of zebrafish is a sensitive target for many environmental pollutants, including dioxin-like compounds and pesticides. Some polychlorinated biphenyls (PCBs) can compromise the cardiovascular endothelial function by activating oxidative stress-sensitive signaling pathways. Therefore, we exposed zebrafish embryos to PCB126 or to several redox-modulating chemicals to study their ability to modulate the dysmorphogenesis produced by PCB126. PCB126 produced a concentration-dependent induction of pericardial edema and circulatory failure, and a concentration-dependent reduction of cardiac output and body length at 80 hours post fertilization (hpf). Among several modulators tested, the effects of PCB126 could be both positively and negatively modulated by different compounds; co-treatment with α-tocopherol (vitamin E liposoluble) prevented the adverse effects of PCB126 in pericardial edema, whereas co-treatment with sodium nitroprusside (a vasodilator compound) significantly worsened PCB126 effects. Gene expression analysis showed an up-regulation of cyp1a, hsp70, and gstp1, indicative of PCB126 interaction with the aryl hydrocarbon receptor (AhR), while the transcription of antioxidant genes (sod1, sod2; cat and gpx1a) was not affected. Further studies are necessary to understand the role of oxidative stress in the developmental toxicity of low concentrations of PCB126 (25 nM). Our results give insights into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of environmental pollutants.

scholarly journals Chromium(VI) Toxicity in Legume Plants: Modulation Effects of Rhizobial Symbiosis

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Uliana Ya. Stambulska ◽  
Maria M. Bayliak ◽  
Volodymyr I. Lushchak
Keyword(s):  
Oxidative Stress ◽  
Plant Biomass ◽  
Environmental Pollutants ◽  
Toxic Effects ◽  
Pigment Synthesis ◽  
Chromium Vi ◽  
Rhizobial Symbiosis ◽  
Promote Plant Growth ◽  
Legume Plants ◽  
Cellular Components

Most legume species have the ability to establish a symbiotic relationship with soil nitrogen-fixing rhizobacteria that promote plant growth and productivity. There is an increasing evidence of reactive oxygen species (ROS) important role in formation of legume-rhizobium symbiosis and nodule functioning. Environmental pollutants such as chromium compounds can cause damage to rhizobia, legumes, and their symbiosis. In plants, toxic effects of chromium(VI) compounds are associated with the increased production of ROS and oxidative stress development as well as with inhibition of pigment synthesis and modification of virtually all cellular components. These metabolic changes result in inhibition of seed germination and seedling development as well as reduction of plant biomass and crop yield. However, if plants establish symbiosis with rhizobia, heavy metals are accumulated preferentially in nodules decreasing the toxicity of metals to the host plant. This review summarizes data on toxic effects of chromium on legume plants and legume-rhizobium symbiosis. In addition, we discussed the role of oxidative stress in both chromium toxicity and formation of rhizobial symbiosis and use of nodule bacteria for minimizing toxic effects of chromium on plants.

scholarly journals The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution

2014 ◽  
Vol 2014 ◽  
pp. 1-22 ◽  
Author(s):  
Borut Poljšak ◽  
Rok Fink
Keyword(s):  
Oxidative Stress ◽  
Nitrosative Stress ◽  
Environmental Pollutants ◽  
Protective Role ◽  
Age Related Macular Degeneration ◽  
Protective Effects ◽  
Age Related ◽  
Dietary Antioxidant ◽  
Polycyclic Aromatic ◽  
Antioxidant Supplements

Overproduction of reactive oxygen and nitrogen species can result from exposure to environmental pollutants, such as ionising and nonionising radiation, ultraviolet radiation, elevated concentrations of ozone, nitrogen oxides, sulphur dioxide, cigarette smoke, asbestos, particulate matter, pesticides, dioxins and furans, polycyclic aromatic hydrocarbons, and many other compounds present in the environment. It appears that increased oxidative/nitrosative stress is often neglected mechanism by which environmental pollutants affect human health. Oxidation of and oxidative damage to cellular components and biomolecules have been suggested to be involved in the aetiology of several chronic diseases, including cancer, cardiovascular disease, cataracts, age-related macular degeneration, and aging. Several studies have demonstrated that the human body can alleviate oxidative stress using exogenous antioxidants. However, not all dietary antioxidant supplements display protective effects, for example,β-carotene for lung cancer prevention in smokers or tocopherols for photooxidative stress. In this review, we explore the increases in oxidative stress caused by exposure to environmental pollutants and the protective effects of antioxidants.

scholarly journals Methanolic Leaves and Arils Extracts of Ackee (Blighia sapida)Plant Ameliorate Mercuric Chloride-Induced Oxidative Stress in Drosophila melanogaster

2020 ◽  
Vol 11 (1) ◽  
pp. 7528-7542
Keyword(s):  
Oxidative Stress ◽  
Mercuric Chloride ◽  
Environmental Pollutants ◽  
Ros Generation ◽  
Glutathione S Transferase ◽  
Negative Geotaxis ◽  
Methanolic Extracts ◽  
Mechanism Of Toxicity ◽  
Antioxidant Effects ◽  
Blighia Sapida

Ackee (Blighia sapida) has been used in traditional medicine for treating oxidative stress-induced diseases; diabetes and cancer. Ameliorative roles of Ackee leaves and arils methanolic extracts were evaluated on mercuric chloride (HgCl2) induced-oxidative stress in D. melanogaster. 1-3 days old D. melanogaster were orally exposed to different concentrations of Ackee leaves (AL), and Ackee arils (AS) extracts as well as HgCl2 in a diet for 7 days. Subsequently, survival and negative geotaxis assays, quantification of reactive oxygen species (ROS) generation, and oxidative biomarker enzymes were determined. 500 µM HgCl2 was selected based on the highest lethality, 0.2 mg/g for AL, and 0.4 mg/g for AS; they gave the highest antioxidant effects. Exposure to AL and AS plant extracts improved negative geotaxis behavior and extracts were able to ameliorate the effect of Hg2+ on catalase positively, acetylcholinesterase, glutathione-S transferase activities, increase total thiol and GSH levels and reverted increased nitric oxide and hydrogen peroxide production (P<0.05) when compared to the control. Our results suggest that the Hg2+ mechanism of toxicity is associated with oxidative damage, as evidenced by the alteration in the oxidative stress-antioxidant imbalance, and that extracts possess essential phytochemicals that could alleviate possibly effects of environmental pollutants such as HgCl2.

scholarly journals BIOMARKERS OF OXIDATIVE STRESS AND ANTIOXIDANT SYSTEM IN EXPERIMENTAL GINGIVITIS AND ITS` CORRECTION WITH PLANT ANTIOXIDANTS

2017 ◽  
Vol 1 (4) ◽  
pp. 28-30
Author(s):  
O. I. Zalyubovska ◽  
T. I. Tiupka ◽  
V. V. Zlenko ◽  
A. O. Minaieva
Keyword(s):  
Oxidative Stress ◽  
Antioxidant System ◽  
Experimental Gingivitis ◽  
Plant Antioxidants ◽  
Biomarkers Of Oxidative Stress

BIOMARKERS OF OXIDATIVE STRESS AND ANTIOXIDANT SYSTEM IN EXPERI- MENTAL GINGIVITIS AND ITS` CORRECTION WITH PLANT ANTIOXIDANTS

scholarly journals Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury via Attenuation of ROS-Mediated Ca2+Overload and Mitochondrial Dysfunction in Human Bronchial Epithelial Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Cai-Xia Liu ◽  
Yu-Rong Tan ◽  
Yang Xiang ◽  
Chi Liu ◽  
Xiao-Ai Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Sulfide ◽  
Cell Injury ◽  
Fluorescence Probe ◽  
Environmental Pollutants ◽  
Cell Counting ◽  
Dependent Manner ◽  
Mitochondria Membrane Potential ◽  
Chemical Hypoxia ◽  
The Impact

Oxidative stress induced by hypoxia/ischemia resulted in the excessive reactive oxygen species (ROS) and the relative inadequate antioxidants. As the initial barrier to environmental pollutants and allergic stimuli, airway epithelial cell is vulnerable to oxidative stress. In recent years, the antioxidant effect of hydrogen sulfide (H2S) has attracted much attention. Therefore, in this study, we explored the impact of H2S on CoCl2-induced cell injury in 16HBE14o- cells. The effect of CoCl2on the cell viability was detected by Cell Counting Kit (CCK-8) and the level of ROS in 16HBE14o- cells in response to varying doses (100–1000μmol/L) of CoCl2(a common chemical mimic of hypoxia) was measured by using fluorescent probe DCFH-DA. It was shown that, in 16HBE14o- cells, CoCl2acutely increased the ROS content in a dose-dependent manner, and the increased ROS was inhibited by the NaHS (as a donor of H2S). Moreover, the calcium ion fluorescence probe Fura-2/AM and fluorescence dye Rh123 were used to investigate the intracellular calcium concentration ([Ca2+]i) and mitochondria membrane potential (MMP) in 16HBE14o- cells, respectively. In addition, we examined apoptosis of 16HBE14o- cells with Hoechst 33342. The results showed that the CoCl2effectively elevated the Ca2+influx, declined the MMP, and aggravated apoptosis, which were abrogated by NaHS. These results demonstrate that H2S could attenuate CoCl2-induced hypoxia injury via reducing ROS to perform an agonistic role for the Ca2+influx and MMP dissipation.

scholarly journals The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells

2019 ◽  
Vol 16 (21) ◽  
pp. 4137 ◽  
Author(s):  
Agata Jabłońska-Trypuć ◽  
Urszula Wydro ◽  
Lluis Serra-Majem ◽  
Elżbieta Wołejko ◽  
Andrzej Butarewicz
Keyword(s):  
Oxidative Stress ◽  
Mammalian Cells ◽  
Human Cancer ◽  
Environmental Pollutants ◽  
Cellular Level ◽  
Human Organism ◽  
Bacterial Strains ◽  
Human Cancer Cells ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Bifenox and Dichlobenil belong to the commonly used in Poland in agriculture group of herbicides and their residues are often detected in the environment. They are poorly known regarding their possible carcinogenic and antibacterial effect at the cellular level. Therefore, we decided to study their activity in bacterial strains Aliivibrio fisheri, E. coli, P. aeruginosa, and C. albicans (yeast) and human cancer ZR-75-1 cells. Compounds under study exhibit stimulatory effect on analyzed bacterial strains. The study performed on mammalian cells better reflects the influence of environmental pollutants on human organism, therefore we evaluated the effect of herbicides on ZR-75-1 cells. Cells viability, apoptosis and selected oxidative stress parameters in ZR-75-1 cells were investigated. Both analyzed substances exhibit stimulatory effects on analyzed parameters, however they do not stimulate apoptosis which correlate positively with the induction of oxidative stress. Bifenox and Dichlobenil enhance oxidative stress parameters by the generation of high levels of ROS, which can lead to their adaptation and resistance to the standard treatment regimen.

scholarly journals Selenium and alpha-tocopherol reduces ϑluoride induced oxidative stress in brain and muscle of mice

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1794-1799
Author(s):  
Chandra Shakar Reddy N ◽  
Pratap Reddy K
Keyword(s):  
Oxidative Stress ◽  
Environmental Pollutants ◽  
Treated Group ◽  
Alpha Tocopherol ◽  
Control Group ◽  
Protective Effects ◽  
Stress Prevention ◽  
Wide Availability ◽  
Markers Of Oxidative Stress ◽  
Ros Formation

Fluoride is one of the common environmental pollutants. Its excessive exposure results in a wide array of toxicity phenotypes including oxidative stress, skeletal and soft tissue damage etc. Antioxidants such as Selenium (Se) and α-tocopherol are attractive agents for oxidative stress prevention because of their safety profile and wide availability. It is known that in combination, Se and alpha-tocopherol act synergistically against ROS formation. This study investigated the protective effects of selenium (05 µg/kg BW) and Alpha-tocopherol (2 mg/kg BW) on markers of oxidative stress in brain and muscle of mice exposed to sodium fluoride (20mg/kg BW) for 15 days. The results showed significant (p<0.05) alterations in markers of oxidative stress includes; an increase in xanthine oxidase activity and lipid peroxidation, a decline in SOD, CAT, GST and GPx activities in fluoride exposure group in comparison with control group indicates oxidative stress induced by fluoride. These changes were reversed modestly in Se and alpha-tocopherol alone treated groups and significantly  (p<0.05) in the combinedly treated group indicating synergistic action in mitigation of fluoride effect.

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