Characterizing Signals Within Lesions and Mapping Brain Network Connectivity After Traumatic Axonal Injury: A 7 Tesla Resting-State FMRI Study

Background: Predicting epilepsy following a first seizure is difficult. Network abnormalities are observed in patients with epilepsy using resting-state functional MRI (rs-fMRI), which worsen with duration of epilepsy. We use rs-fMRI to identify network abnormalities in patients after a first seizure that can be used as a biomarker to predict development of epilepsy. Methods: Patients after a single, unprovoked seizure and age/sex matched healthy controls underwent 7 Tesla structural and resting-state functional MRI. Data were analyzed using graph theory measures. Patients were followed for development of epilepsy. Results: Nine patients and nine control subjects were analyzed. There were no differences in baseline characteristics. No patients developed epilepsy (average follow-up 3 months). No differences between groups occurred on a whole-brain network level. At a 20% threshold, significant differences occurred in the default mode network (DMN). Patients demonstrated an increased local efficiency (p=0.02) and clustering coefficient (p=0.04), and decreased path length (p=0.02) and betweenness centrality (p=0.02). Conclusions: No whole-brain network changes occur after a single unprovoked seizure. No patient has developed epilepsy suggesting this group does not have network alterations after a single seizure. In the DMN, the alterations noted indicate increased segregation of network function.

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Childhood Trauma Associated With Abnormal Resting-State Brain Network Connectivity in First-Episode Schizophrenia Patients

10.21203/rs.3.rs-73545/v1 ◽

2020 ◽

Author(s):

Xiangyun Long ◽

Jiaxin Wu ◽

Fei Liu ◽

Ansi Qi ◽

Nan Huang ◽

...

Keyword(s):

Childhood Trauma ◽

Resting State ◽

Network Connectivity ◽

Brain Network ◽

Traumatic Experiences ◽

First Episode ◽

Resting State Networks ◽

Attention Network ◽

Brain Network Connectivity ◽

First Episode Schizophrenia

Abstract Childhood trauma is a central risk factor for schizophrenia. We explored the correlation between early traumatic experiences and the functional connectivity of resting-state networks. This fMRI study included 28 first-episode schizophrenia patients and 27 healthy controls. In first-episode schizophrenia patients, higher levels of childhood trauma associated with abnormal connections of resting-state networks, and these anomalies distributed among task-positive networks (i.e., ventral attention network, dorsal-ventral attention network and frontal-parietal network), and sensory networks (i.e., visual network and auditory network). These findings mentioned that childhood traumatic experiences may impact resting-state network connectivity in adulthood, mainly involving systems related to attention and execution control.

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Resting-state neural network disturbances that underpin the emergence of emotional symptoms in adolescent girls: resting-state fMRI study

The British Journal of Psychiatry ◽

10.1192/bjp.2019.10 ◽

2019 ◽

Vol 215 (3) ◽

pp. 545-551 ◽

Cited By ~ 3

Author(s):

Gin S. Malhi ◽

Pritha Das ◽

Tim Outhred ◽

Richard A. Bryant ◽

Vince Calhoun

Keyword(s):

Emotional Disorders ◽

Adolescent Girls ◽

Resting State ◽

Early Adulthood ◽

Network Connectivity ◽

Resting State Fmri ◽

Imaging Data ◽

Emotional Symptoms ◽

Fmri Study ◽

The Right

BackgroundSubsyndromal emotional symptoms in adolescence may represent precursors for full-blown emotional disorders in early adulthood. Understanding the neurobiological mechanisms that drive this development is essential for prevention.AimsSelf-referential processing and emotion regulation are remodelled substantively during adolescence, therefore this study examined integration of key neural networks involved in these processes.MethodAt baseline, clinical and resting-state functional magnetic resonance imaging data were collected for 88 adolescent girls (mean age 15 years), and 71 of these girls underwent repeat clinical assessment after 2 years. These 71 girls were then partitioned into two groups depending on the presence (ES+) or absence (ES−) of emotional symptoms, and differences in dynamic functional network connectivity were determined and correlated with clinical variables.ResultsThe two groups displayed a differential pattern of functional connectivity involving the left lateral prefrontal network (LPFN). Specifically, in the ES+ group this network displayed positive coupling with the right LPFN but negative coupling with the default mode network, and the inverse of this pattern was found in the ES− group. Furthermore, the coupling strengths between left and right LPFN at the irst time point predicted follow-up depression and state anxiety scores.ConclusionsOur findings suggest that in adolescent girls, emotional symptoms may emerge as a result of impaired integration between networks involved in self-referential information processing and approach-avoidance behaviours. These impairments can compromise the pursuit of important goals and have an impact on emotion processing and finally may lead to the development of emotional disorders, such as anxiety and depression in adulthood.Declaration of interestNone.

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GAIT VARIABILITY CORRELATES WITH RESTING-STATE BRAIN NETWORK CONNECTIVITY IN AGING AND DISEASE

Innovation in Aging ◽

10.1093/geroni/igy023.1919 ◽

2018 ◽

Vol 2 (suppl_1) ◽

pp. 518-518

Author(s):

O Lo ◽

M Halko ◽

J Zhou ◽

W Cheong ◽

R Harrison ◽

...

Keyword(s):

Resting State ◽

Network Connectivity ◽

Brain Network ◽

Gait Variability ◽

Brain Network Connectivity

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Disrupted brain network topology in pediatric posttraumatic stress disorder: A resting-state fMRI study

Human Brain Mapping ◽

10.1002/hbm.22871 ◽

2015 ◽

Vol 36 (9) ◽

pp. 3677-3686 ◽

Cited By ~ 55

Author(s):

Xueling Suo ◽

Du Lei ◽

Kaiming Li ◽

Fuqin Chen ◽

Fei Li ◽

...

Keyword(s):

Posttraumatic Stress Disorder ◽

Posttraumatic Stress ◽

Network Topology ◽

Resting State ◽

Stress Disorder ◽

Resting State Fmri ◽

Brain Network ◽

Fmri Study

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Advanced Meditation Alters Resting-State Brain Network Connectivity Correlating With Improved Mindfulness

Frontiers in Psychology ◽

10.3389/fpsyg.2021.745344 ◽

2021 ◽

Vol 12 ◽

Author(s):

Ramana V. Vishnubhotla ◽

Rupa Radhakrishnan ◽

Kestas Kveraga ◽

Rachael Deardorff ◽

Chithra Ram ◽

...

Keyword(s):

Functional Connectivity ◽

Resting State ◽

Network Connectivity ◽

Blood Oxygen Level Dependent ◽

Brain Network ◽

Resting State Functional Connectivity ◽

Blood Oxygen Level ◽

Default Mode ◽

Before And After ◽

Brain Network Connectivity

Purpose: The purpose of this study was to investigate the effect of an intensive 8-day Samyama meditation program on the brain functional connectivity using resting-state functional MRI (rs-fMRI).Methods: Thirteen Samyama program participants (meditators) and 4 controls underwent fMRI brain scans before and after the 8-day residential meditation program. Subjects underwent fMRI with a blood oxygen level dependent (BOLD) contrast at rest and during focused breathing. Changes in network connectivity before and after Samyama program were evaluated. In addition, validated psychological metrics were correlated with changes in functional connectivity.Results: Meditators showed significantly increased network connectivity between the salience network (SN) and default mode network (DMN) after the Samyama program (p < 0.01). Increased connectivity within the SN correlated with an improvement in self-reported mindfulness scores (p < 0.01).Conclusion: Samyama, an intensive silent meditation program, favorably increased the resting-state functional connectivity between the salience and default mode networks. During focused breath watching, meditators had lower intra-network connectivity in specific networks. Furthermore, increased intra-network connectivity correlated with improved self-reported mindfulness after Samyama.Clinical Trials Registration: [https://clinicaltrials.gov], Identifier: [NCT04366544]. Registered on 4/17/2020.

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Altered electroencephalography resting state network coherence in remitted MDD

10.31234/osf.io/ywqvx ◽

2021 ◽

Author(s):

Kimberly L Ray ◽

Nicholas Griffin ◽

Jason Shumake ◽

Alexandra Alario ◽

John B. Allen ◽

...

Keyword(s):

Resting State ◽

Network Connectivity ◽

Brain Network ◽

Healthy Adults ◽

Average Reference ◽

Brain Network Connectivity ◽

Eeg Connectivity ◽

Eeg Power ◽

Remitted Depression ◽

Power Analyses

Individuals with remitted depression are at greater risk for subsequent depression and therefore may provide a unique opportunity to understand the neurophysiological correlates underlying the risk of depression. Research has identified abnormal resting-state electroencephalography (EEG) power metrics and functional connectivity patterns associated with major depression, however little is known about these neural signatures in individuals with remitted depression. We investigate the spectral dynamics of 64-channel EEG surface power and source-estimated network connectivity during resting states in 37 individuals with depression, 56 with remitted depression, and 49 healthy adults that did not differ on age, education, and cognitive ability across theta, alpha, and beta frequencies. Average reference spectral EEG surface power analyses identified greater left and midfrontal theta in remitted depression compared to healthy adults. Using Network Based Statistics, we also demonstrate within and between network alterations in LORETA transformed EEG source-space coherence across the default mode, fronto-parietal, and salience networks where individuals with remitted depression exhibited enhanced coherence compared to those with depression, and healthy adults. This work builds upon our currently limited understanding of resting EEG connectivity in depression, and helps bridge the gap between aberrant EEG power and brain network connectivity dynamics in this disorder. Further, our unique examination of remitted depression relative to both healthy and depressed adults may be key to identifying brain-based biomarkers for those at high risk for future, or subsequent depression.

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