The Renin Angiotensin System as a potential treatment target for Traumatic Brain Injury

2022 ◽  
Author(s):  
Daniel Hendrik Baron ◽  
Olivia A Skrobot ◽  
Jennifer C Palmer ◽  
Kanchan Sharma ◽  
Patrick Kehoe
Author(s):  
João Luís Vieira Monteiro de Barros ◽  
Maíra Glória Cardoso ◽  
Caroline Amaral Machado ◽  
Érica Leandro Marciano Vieira ◽  
Rodrigo Moreira Faleiro ◽  
...  

2016 ◽  
Vol 130 (4) ◽  
pp. 221-238 ◽  
Author(s):  
Abdelrahman Y. Fouda ◽  
Sandeep Artham ◽  
Azza B. El-Remessy ◽  
Susan C. Fagan

This review examines the published literature on the role of the renin-angiotensin system in neurovascular disorders including stroke, retinopathy, traumatic brain injury and cognitive impairment. The review presents both experimental and clinical studies conducted in the field, and sheds light on the translational gap and clinical underutilization of renin-angiotensin system modulators in neurovascular disorders.


2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Ling Lu ◽  
Xiaomei Liu ◽  
Rong Jin ◽  
Renzheng Guan ◽  
Rongjun Lin ◽  
...  

The spread of pathogenic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a global health emergency. Based on the symptomatic treatment and supporting therapy, prevention of complications is the major treatment option. Therefore, it is necessary to illustrate the potential mechanisms for the pathogenesis of COVID-19. Angiotensin-converting enzyme 2 (ACE2), the major receptor of SARS-CoV-2, is one of the major members of the renin-angiotensin system (RAS). In this review, we aimed to summarize the crucial roles of ACE2 in the pathogenesis of COVID-19, followed by illustrating potential treatment options relating to ACE2 and the RAS.


2004 ◽  
Vol 101 (20) ◽  
pp. 7775-7780 ◽  
Author(s):  
M.-C. Fournie-Zaluski ◽  
C. Fassot ◽  
B. Valentin ◽  
D. Djordjijevic ◽  
A. Reaux-Le Goazigo ◽  
...  

2021 ◽  
Author(s):  
Tiago de Oliveira Furlam ◽  
Ewelin Wasner Machado da Silva ◽  
Isadora Gonçalves Roque ◽  
Pedro Parenti Vianna ◽  
Rafael Arantes de Oliveira ◽  
...  

Background: The Renin-Angiotensin System (RAS) has been associated with several neuropathologies, including traumatic brain injury (TBI). Objectives: Assess the relationship between RAS and mild TBI within 24 hours after trauma. Design and setting: A case-control study developed by the Federal University of Minas Gerais and conducted at the Hospital João XXIII, Belo Horizonte, Minas Gerais, Brazil. Methods: Sociodemographic data and blood samples were collected from 52 individuals, of whom 28 suffered mild TBI in the 24 hours prior to collection and 24 healthy individuals made up the control group. The serum was used to measure the components of the RAS. Results: There were no significant sociodemographic differences between groups regarding to sex and age (p=0.782; p=0.077). Of the experimental group, 15 individuals reported loss of consciousness and 11 reported previous TBI. The experimental group showed significantly higher concentrations of angiotensin II (p=0.0234) and angiotensin-(1-7) (p=0.0225) and significantly lower concentrations of angiotensin converting enzyme (ACE) (p=0.0004) and ACE2 (p=0.0047). Conclusion: RAS seems to be involved in the pathophysiology of the hyperacute phase of mild TBI and the study of its components may contribute to identify prognostic biomarkers and new therapeutic targets for patients victims of TBI.


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