Infraorbital Hyaluronic Acid Filler: Common Aesthetic Side Effects with Treatment and Prevention Options

Aesthetic Surgery Journal Open Forum ◽

10.1093/asjof/ojac001 ◽

2022 ◽

Author(s):

Robyn Siperstein

Keyword(s):

Hyaluronic Acid ◽

Side Effects ◽

Treatment Decision ◽

Treatment And Prevention ◽

Complex Anatomy ◽

Blue Discoloration ◽

Thin Skin ◽

Injection Techniques ◽

Short And Long Term

Abstract Background Infraorbital hollows can give a fatigued or aged appearance which can be treated by volumizing the segmented transition from the tear trough to the cheek with hyaluronic acid filler. Due to thin skin and the complex anatomy of the infraorbital area, both short- and long-term side effects from this treatment are very common. While some patients are clear surgical candidates vs. filler candidates, in real-world practice, many, if not most patients are on a continuum where either procedure is appropriate, and the treatment decision is individualized based on each person’s risk vs. benefit profile. Objectives Common aesthetic side effects from hyaluronic acid filler treatment in the infraorbital area will be reviewed, including their etiology, prevention, detection, and treatment. Method The authors’ experience from injecting the infraorbital areas of more than 800 patients in private clinical practice and observations from both short and long-term follow ups over eight years is leveraged to provide detailed guidance. Results Recommendations on injection techniques, patient selection, and patient education are presented along with algorithms for the prevention and management of bruising, short- and long-term swelling, bumps, and blue discoloration (which is usually secondary to swelling from the filler rather than just the filler alone placed or migrating too superficially). Conclusion For nearly all patients, complete dissolution of filler with hyaluronidase is not required to address the issue, and the guidelines provided here will assist clinicians in management of side effects to increase patient satisfaction with their treatment and aesthetic outcome.

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903 poster External radiotherapy (RT) for prostate carcinoma (PC) in older patients — Analysis of short and long-term side effects

Radiotherapy and Oncology ◽

10.1016/s0167-8140(04)82770-1 ◽

2004 ◽

Vol 73 ◽

pp. S383

Keyword(s):

Side Effects ◽

Prostate Carcinoma ◽

Older Patients ◽

External Radiotherapy ◽

Short And Long Term

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Influences on Attitudes Regarding Potential COVID-19 Vaccination in the United States

Vaccines ◽

10.3390/vaccines8040582 ◽

2020 ◽

Vol 8 (4) ◽

pp. 582 ◽

Cited By ~ 6

Author(s):

Kendall Pogue ◽

Jamie L. Jensen ◽

Carter K. Stancil ◽

Daniel G. Ferguson ◽

Savannah J. Hughes ◽

...

Keyword(s):

United States ◽

Structural Equation Modeling ◽

Side Effects ◽

Structural Equation ◽

The United States ◽

Equation Modeling ◽

Vaccine Acceptance ◽

The World ◽

Short And Long Term

The COVID-19 pandemic continues to ravage the world, with the United States being highly affected. A vaccine provides the best hope for a permanent solution to controlling the pandemic. However, to be effective, a vaccine must be accepted and used by a large majority of the population. The aim of this study was to understand the attitudes towards and obstacles facing vaccination with a potential COVID-19 vaccine. To measure these attitudes a survey was administered to 316 respondents across the United States by a survey corporation. Structural equation modeling was used to analyze the relationships of several factors with attitudes toward potential COVID-19 vaccination. Prior vaccine usage and attitudes predicted attitudes towards COVID-19 vaccination. Assessment of the severity of COVID-19 for the United States was also predictive. Approximately 68% of all respondents were supportive of being vaccinated for COVID-19, but side effects, efficacy and length of testing remained concerns. Longer testing, increased efficacy and development in the United States were significantly associated with increased vaccine acceptance. Messages promoting COVID-19 vaccination should seek to alleviate the concerns of those who are already vaccine-hesitant. Messaging directed at the benefits of vaccination for the United States as a country would address the second predictive factor. Enough time should be taken to allay concerns about both short- and long-term side effects before a vaccine is released.

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THE SHORT AND LONG TERM INCIDENCE OF SIDE EFFECTS OF PHENELZINE

InPharma ◽

10.1007/bf03297449 ◽

1982 ◽

Vol 354 (1) ◽

pp. 5-5

Keyword(s):

Side Effects ◽

Short And Long Term

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SPECIAL REQUIREMENTS FOR TOXICITY TESTING OF ORAL COMPOUNDS ADMINISTERED CONTINUOUSLY OR CYCLICALLY

Acta Endocrinologica ◽

10.1530/acta.0.075s387 ◽

1974 ◽

Vol 77 (1_Suppla) ◽

pp. S387-S408 ◽

Cited By ~ 2

Author(s):

G. A. Overbeek ◽

H. W. Hornstra ◽

E. B. van Julsingha ◽

J. P. Mumford ◽

I. Zayed

Keyword(s):

Side Effects ◽

Oral Contraceptives ◽

Predictive Value ◽

Animal Studies ◽

Toxicity Testing ◽

Prolonged Treatment ◽

Safety Studies ◽

Short And Long Term ◽

Dose Levels

ABSTRACT The authors feel that several reasons exist for considering contraceptives as a special class of drugs, which therefore require special safety studies. Apart from the usual short and long term studies, particular attention should be paid to the reversibility of the induced infertility, and to its possible consequences for subsequent offspring. A possible risk of damage to the foetus is partially outweighed by the low risk of pregnancy during the treatment periods with oral contraceptives. The procedures used in the Organon laboratories are briefly described. Principles on which we base the choice of dose levels and the duration of the various studies are discussed. The paucity of available data from toxicity studies in animals has prevented the presentation of a summary allowing an appraisal of the predictive value of the current methods in toxicology. Nevertheless, a few examples are given which demonstrate the need for more predictive methods. The present lack of knowledge on side effects in humans after prolonged treatment with oral contraceptives has created a feeling of uneasiness. This in its turn has resulted in some excessive regulatory requirements for very long term animal studies. In our opinion, the predictive value of these studies is extremely low because of the inadequacy of the available animal models. More value can be attached to the monitoring of side effects in humans and efforts in this direction should be increased. The Organon system of monitoring the side effects of its marketed preparations is briefly described. It is not considered feasible to standardize regulatory toxicity requirements for the time being, which should not prevent us from aiming at reasonable, more generally accepted methods of study.

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Influences on Attitudes regarding Potential COVID-19 Vaccination in the United States

10.20944/preprints202009.0338.v1 ◽

2020 ◽

Author(s):

Kendall Pogue ◽

Jamie Jensen ◽

Carter Stancil ◽

Daniel Ferguson ◽

Savannah Hughes ◽

...

Keyword(s):

United States ◽

Side Effects ◽

Predictive Factor ◽

Structural Equation ◽

The United States ◽

Vaccine Acceptance ◽

Equation Modelling ◽

The World ◽

Short And Long Term

The COVID-19 pandemic continues to ravage the world, with the United States being highly affected. A vaccine provides the best hope for a permanent solution to controlling the pandemic. However, to be effective, a vaccine must be accepted and used by a large majority of the population. Structural equation modelling was used to analyze the relationships of several factors with attitudes toward potential COVID-19 vaccination. The survey was administered to 316 respondents across the United States by a survey corporation. Prior vaccine usage and attitudes predicted attitudes towards COVID-19 vaccination. Assessment of the severity of COVID-19 for the United States was also predictive. Approximately 68% of all respondents were supportive of being vaccinated for COVID-19, but side effects, efficacy, and length of testing remained concerns. Longer testing, increased efficacy and development in the United States were significantly associated with increased vaccine acceptance. Messages promoting COVID-19 vaccination should seek to alleviate the concerns of those who are already vaccine-hesitant. Messaging directed at the benefits of vaccination for the United States as a country would address the second predictive factor. Enough time should be taken to allay concerns about both short and long-term side effects before a vaccine is released.

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Single Donor Plasma in Therapeutic Plasma Exchange for Myasthenia Gravis

The International Journal of Artificial Organs ◽

10.1177/039139888701000509 ◽

1987 ◽

Vol 10 (5) ◽

pp. 315-318 ◽

Cited By ~ 7

Author(s):

R. Mantegazza ◽

E. Bruzzone ◽

B. Regi ◽

D. Peluchetti ◽

M. Marconi ◽

...

Keyword(s):

Side Effects ◽

Myasthenia Gravis ◽

Plasma Exchange ◽

Optimal Schedule ◽

Therapeutic Plasma Exchange ◽

Single Donor ◽

Short And Long Term ◽

Donor Plasma

Thirty-seven myasthenic patients were treated with therapeutic plasma exchange (TPE) on different performance schedules using either random or single donor plasma. The two schedules had the same effects in terms of efficacy but single donor replacement gave significantly less side effects in the short and long term. A two exchange procedure on alternate days associated with immunosuppression seems to be an optimal schedule for the treatment of myasthenic patients. A single donor two-exchange on alternate days procedure appears to be safe, useful and can be repeated in patients who need frequent TPE.

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Efektivitas Dan Keamanan Vaksin Covid-19 : Studi Refrensi

Jurnal Keperawatan Profesional ◽

10.33650/jkp.v9i2.2767 ◽

2021 ◽

Vol 9 (2) ◽

pp. 61-107

Author(s):

Setiyo Adi Nugroho ◽

Indra Nur Hidayat

Keyword(s):

Clinical Trials ◽

Side Effects ◽

Public Confidence ◽

Study Approach ◽

A Value ◽

Study Results ◽

Approach Method ◽

Short And Long Term ◽

Protective Effectiveness

Various strategies and development of the Covid-19 vaccine have been carried out for the control of the Covid-19 pandemic. Various vaccines have undergone clinical trials with promising results in various countries. The effectiveness and safety and short- and long-term side effects of vaccines are a major concern in clinical trials in these strategies and developments. Purpose: The purpose of this study is to find out the effectiveness and safety of the Covid-19 vaccine so that it can inform and increase public confidence in the Covid-19 vaccine through a reference study approach. Method: The research method we use here is a reference study using electronic databases through journals from international and national. Google Scholar, science direx, elsiver, Pubmed are used as the main Journal database for this reference study. Results: From the results of reference studies found that all vaccines in clinical trials have promising effectiveness and safety. The Pfizer-BiONTech vaccine is a vaccine that has a good level of effectiveness and safety with a value of 94.6% and does not cause serious side effects. Double-dose vaccination further improves the immune response in younger and older adults. Conclusion: The Covid-19 vaccine in clinical trials all demonstrates promising immunogenicity with varying levels of protective effectiveness and an acceptable safety profile.

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