scholarly journals 529 Safeguarding Skin Grafts: A 21st Century Algorithm for Fixation Techniques

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
B Patel ◽  
C Asher ◽  
N Bystrzonowski ◽  
C Healy

Abstract Aim Effective skin graft fixation is fundamental in preventing sheering forces, seroma and haematoma from compromising graft take. However, determining the ideal method of graft fixation remains a contentious subject. Currently, there is significant variation in fixation techniques used, based not only on clinical requirement, but also surgeon preference. Evidence-based recommendations are necessary to guide the decision-making process. Method We undertook a PRISMA-based assessment of the literature to define all fixation techniques and analyse their outcomes. Inclusion and exclusion criteria were composed. A search of Medline and Embase was performed, yielding 399 articles. After abstract screening, 96 were included for qualitative data analysis. Results Nine fixation techniques were identified: ‘tie over bolster’, ‘staple fixation’, ‘simple dressings’, ‘quilting sutures’, ‘re-look methods’, ‘foam sponge bolster’, ‘adhesive glues’, ‘negative pressure wound therapy’ and ‘less common techniques. We analyse the available evidence for each technique, identifying 13 studies with level I/II evidence. We summarise the research that underpins these nine categories, proposing an algorithm to facilitate technique selection based on anatomical and patient-specific factors. Conclusions An array of skin graft fixation techniques are used in plastic surgery, without clear guidelines. To our knowledge, this is the first time all fixation techniques have been defined. Our suggested algorithm is intended to aid surgeons in selecting an appropriate fixation technique and should be challenged by future research, particularly randomised control trials.

2021 ◽  
pp. 002205742110164
Author(s):  
Mohammad Zahir Raihan ◽  
Md. Abul Kalam Azad

The outcome-based learning for graduate employability in higher education has been an important research topic among the policymakers, academicians, and researchers over the years. Yet, no bibliometric review on this topic has been published. This study, for the first time, examines bibliometric analysis on this topic examining current research trend and future research agenda. The bibliometrix package in R software and VOSviewer software are used for visualization and interpretation of results. A content analysis is performed to manually examine the bibliometric results.


Author(s):  
Gregory J. H. Biddle ◽  
Joseph Henson ◽  
Stuart J. H. Biddle ◽  
Melanie J. Davies ◽  
Kamlesh Khunti ◽  
...  

Isotemporal substitution modelling (ISM) and compositional isotemporal modelling (CISM) are statistical approaches used in epidemiology to model the associations of replacing time in one physical behaviour with time in another. This study’s aim was to use both ISM and CISM to examine and compare associations of reallocating 60 min of sitting into standing or stepping with markers of cardiometabolic health. Cross-sectional data collected during three randomised control trials (RCTs) were utilised. All participants (n = 1554) were identified as being at high risk of developing type 2 diabetes. Reallocating 60 min from sitting to standing and to stepping was associated with a lower BMI, waist circumference, and triglycerides and higher high-density lipoprotein cholesterol using both ISM and CISM (p < 0.05). The direction and magnitude of significant associations were consistent across methods. No associations were observed for hemoglobin A1c, total cholesterol, or low-density lipoprotein cholesterol for either method. Results of both ISM and CISM were broadly similar, allowing for the interpretation of previous research, and should enable future research in order to make informed methodological, data-driven decisions.


Toxins ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 133 ◽  
Author(s):  
Annika Jagels ◽  
Viktoria Lindemann ◽  
Sebastian Ulrich ◽  
Christoph Gottschalk ◽  
Benedikt Cramer ◽  
...  

The genus Stachybotrys produces a broad diversity of secondary metabolites, including macrocyclic trichothecenes, atranones, and phenylspirodrimanes. Although the class of the phenylspirodrimanes is the major one and consists of a multitude of metabolites bearing various structural modifications, few investigations have been carried out. Thus, the presented study deals with the quantitative determination of several secondary metabolites produced by distinct Stachybotrys species for comparison of their metabolite profiles. For that purpose, 15 of the primarily produced secondary metabolites were isolated from fungal cultures and structurally characterized in order to be used as analytical standards for the development of an LC-MS/MS multimethod. The developed method was applied to the analysis of micro-scale extracts from 5 different Stachybotrys strains, which were cultured on different media. In that process, spontaneous dialdehyde/lactone isomerization was observed for some of the isolated secondary metabolites, and novel stachybotrychromenes were quantitatively investigated for the first time. The metabolite profiles of Stachybotrys species are considerably influenced by time of growth and substrate availability, as well as the individual biosynthetic potential of the respective species. Regarding the reported adverse effects associated with Stachybotrys growth in building environments, combinatory effects of the investigated secondary metabolites should be addressed and the role of the phenylspirodrimanes re-evaluated in future research.


Author(s):  
Piotr Michoń

AbstractThe need for qualitative research of deservingness perception is strongly emphasised in the literature. This article studies the perception of deservingness for a "Family 500 +"—cash benefit in Poland. For the first time, data from online forums was used in the studies of deservingness and welfare attitudes. It allowed to avoid numerous limitations associated with social surveys. The qualitative analysis showed how participants of Internet debates perceive the criteria of deservingness: control, attitude, reciprocity, identity, need, and what are the relations between the criteria. The impurity of all deservingness criteria was indicated and a new criterion “adequacy” was proposed. Moreover due to the fact that the study concerned a concrete, non-abstract family cash benefit addressed the relationship between the perceived deservingness of children and their parents was pointed out. The vast majority of posts on Internet forums referred to deservingness of parents, not children. This is particularly evident in relation to the criteria of control and reciprocity. Presenting the hypothesis of jealousy and scapegoat strategy, the article also shows the direction of future research on deservingness.


1997 ◽  
Vol 99 (2) ◽  
pp. 601-602 ◽  
Author(s):  
Renato Saltz ◽  
Jason B. Bowles
Keyword(s):  

Burns ◽  
2006 ◽  
Vol 32 (3) ◽  
pp. 305-311 ◽  
Author(s):  
Rainer Mittermayr ◽  
Esther Wassermann ◽  
Martin Thurnher ◽  
Manuela Simunek ◽  
Heinz Redl

This book is a ground-breaking study of the phenomenon of migration in and to England over the medieval millennium, between c. AD 500 and c. AD 1500. It reaches across traditional scholarly divides, both disciplinary and chronological, to investigate, for the first time, the different types of data and scholarly methods that reveal evidence of migration and mobility within the medieval kingdom of England. England offers the opportunity for studying migration and migrants over the longue durée, because it has been a recognisable political unit for over a millennium and because a wealth of source material has survived from these centuries. The data vary unevenly in quality and quantity across this period, but become considerably more powerful through multi-disciplinary approaches to data collection and interpretation. Fifteen subject specialists synthesise and extend recent research in a wide range of disciplines, including archaeology, art history, genetics, historical linguistics, history, literature and onomastics. They evaluate the capacity of different genres of evidence for addressing questions around migration and its effects on the identities of groups and individuals within medieval England, as well as methodological parameters and future research potential. The book therefore marks an important contribution to medieval studies, and to modern debates on migration and the free movement of people, arguing that migration in the modern world, and its reverberations, cannot be completely understood without taking a broad historical perspective on the topic.


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