scholarly journals Comparison of Label Claims, Measured Curcuminoid Content and Dosage Form Performance Quality With Industry Standards for Turmeric Dietary Supplements

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 296-296
Author(s):  
Karen Andrews ◽  
Pavel Gusev ◽  
Sushma Savarala ◽  
Phuong-Tan Tey ◽  
Laura Oh ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Certified Reference Materials ◽  
Curcuma Longa ◽  
Quality Of Results ◽  
Funding Sources ◽  
Performance Quality ◽  
Industry Standards ◽  
Labeling Requirements ◽  
Soft Gels

Abstract Objectives Turmeric (Curcuma longa) is a popular ingredient in dietary supplements (DS), promoted for a variety of health effects. FDA label regulations require information on the total weight of each botanical or extract present in a botanical DS, unless it is part of a proprietary blend. Information on the concentration of phytochemicals in extracts is voluntary. DS with turmeric rhizome powders and/or extracts were tested for curcuminoid content and the results compared to label claims and industry standards as part of the Dietary Supplement Ingredient Database (DSID) research program. The performance quality of the dosage forms was also evaluated. Methods Commonly consumed DS (n = 54 × 2 lots) with turmeric as the only or primary ingredient were analyzed for curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Certified reference materials, in-house controls and blind sample duplicates were measured to ensure the quality of results from three laboratories. Percentages of total curcuminoids (TC) and ratios of the three curcuminoids were compared to published standards. Voluntary content claims were categorized as “complete” (all listed turmeric ingredients had a TC claim) or “partial” (only one of two had a TC claim). Tablets/caplets (n = 9) and capsules (n = 39) were also tested for disintegration and soft gels (n = 4) for rupture. Results Measured TC amounts varied widely among products. At the most common labeled level of 500 mg of turmeric per day, measured TC results ranged from 16 to 554 mg (n = 12). DS with voluntary claims for TC (n = 41) had analytical content averaging 6.2% above label, and 63% within ± 10% of claims. DS with complete TC claims had significantly higher levels in mg per day than those with partial or no claims (735 ± 87, 137 ± 37, 196 ± 57; mean ± SE, respectively). The curcuminoid ratios and/or the percentages of TC differed significantly from United States Pharmacopeial (USP) standards for at least 10 DS. Most (87.5%) DS passed disintegration tests and all soft gels passed the rupture test. Conclusions Current labeling requirements for turmeric DS may be insufficient to inform researchers and consumers about the actual content of TC in DS because the extract concentrations vary widely. Voluntary claims for TC amounts were reasonably accurate. Most turmeric DS met USP disintegration and composition standards. Funding Sources NIH-ODS and USDA-ARS.

scholarly journals Development of Genistein Synthesis for Use as a Certified Reference Material

2021 ◽  
Vol 10 (4) ◽  
pp. 20-31
Author(s):  
A. A. Zhigalina ◽  
V. G. Dudarev ◽  
V. V. Tikhonova ◽  
O. Yu. Strelova
Keyword(s):  
Dietary Supplements ◽  
Certified Reference Materials ◽  
Wide Spectrum ◽  
Metrological Traceability ◽  
Pharmacological Action ◽  
Biochanin A ◽  
Pharmaceutical Chemistry ◽  
Mass Selective Detector ◽  
Spectrum Characteristics

Introduction. The use of certified reference materials (CRMs) ensures metrological traceability and comparability of analysis results performed in different laboratories, by different analysts, at different times. Genistein is a promising substance with a wide spectrum of pharmacological action. genistein is widely used in dietary supplements. Development of regulatory documents for CRM of genistein will ensure the quality of drugs and dietary supplements.Aim. Aim of our study is to improve of the ways of synthesis and determination of spectrum characteristics of genistein for the certification of CRM.Materials and methods. We used synthetic genistein, (Ph.D. V. Yu. Kovtun SPC "Pharmzashchita") (sample № 1) and genistein synthesized and studied at the departments of pharmaceutical chemistry and chemical technology of medicinal substances SPCPU (sample № 2). Infrared spectra of genistein samples were collected on an FSM 1201 infrared Fourier spectrometer (OOO Infraspek, Russia) via KBr pellets technique. All the spectra were collected in the 4000–500 cm−1 range. The NMR (1H and 13C) measurements were performed with a BrukerAvance III NMR spectrometer (400 and 100 MHz) (Bruker, Germany) in DMSO-d6 solvent. Raman spectra were recorded by an ORTES-785TRS-2700 analytical Raman scattering system at a laser power of 100 mW (OPTEC JSC, Russia). Laser interaction time was 5, 10, 20 and 60 seconds. The results were processed using the software "BWSpec 4.10_4", USA. GC-MS was performed on an Agilent Technologies 7890A gas chromatograph (Agilent Technologies, USA) with a 7693 autoinjector and a Hewlett Packard 5975C mass selective detector.Results and discussion. The synthesis was carried out according to the developer's method. The stage "removal of the alkyl protection" has been improved. The spectra of the synthesis intermediate of genistein (biochanin A) correspond to the literature data. Samples of genistein were investigated by methods: MC and NMR 13С, 1Н. The structure of the investigated substance was confirmed; Raman and IR spectroscopy showed that the spectra of the samples do not differ from each other and there are no additional signals.Conclusion. The spectrum characteristics of samples of genistein were obtained by NMR, IR and Raman spectroscopy, which will be used in the regulatory documentation for CRM of genistein. All of this will make it possible to control the quality of medicines based on it and to identify substandard dietary supplements.

Resistance Monitor and Control for Vacuum Evaporation of Metals and Carbon

1976 ◽  
Vol 34 ◽  
pp. 572-573
Author(s):  
Russell L. Steere ◽  
Eric F. Erbe ◽  
J. Michael Moseley
Keyword(s):  
Electronic Device ◽  
Point Sources ◽  
High Contrast ◽  
Variable Resistor ◽  
Quality Of Results ◽  
Low Contrast ◽  
Evaporation Source ◽  
And Control ◽  
At Will

We have designed and built an electronic device which compares the resistance of a defined area of vacuum evaporated material with a variable resistor. When the two resistances are matched, the device automatically disconnects the primary side of the substrate transformer and stops further evaporation.This approach to controlled evaporation in conjunction with the modified guns and evaporation source permits reliably reproducible multiple Pt shadow films from a single Pt wrapped carbon point source. The reproducibility from consecutive C point sources is also reliable. Furthermore, the device we have developed permits us to select a predetermined resistance so that low contrast high-resolution shadows, heavy high contrast shadows, or any grade in between can be selected at will. The reproducibility and quality of results are demonstrated in Figures 1-4 which represent evaporations at various settings of the variable resistor.

Ways of increasing performance quality of mowers and headers

2017 ◽  
pp. 7-13
Author(s):  
Nikolai V. Aldoshin ◽  
◽  
Aleksandr A. Zolotov ◽  
Nikolai A. Lylin
Keyword(s):  
Performance Quality

Managament of Bhagandara (Fistula-in-Ano) by Palasha Ksharasutra prepared with Arkaksheera - A Case Report.

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Ganapathi Rao ◽  
Vijay Kumar ◽  
Ashok Naikar ◽  
Chandrakanth Halli
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Success Rate ◽  
Spinal Anesthesia ◽  
Curcuma Longa ◽  
Weekly Interval ◽  
Butea Monosperma ◽  
Fistula In Ano

A standard Ksharasutra is practiced in treatment of Bhagandara (fistula-in-ano) with high success rate and minimum recurrence rate. In previous research it was noted that Pittaja Prakruti patients sometime might cause more perianal irritation due to Apamarga Ksharasutra. So in this study Palasha Ksharasutra prepared in Arkaksheera was prepared by Palasha Kshara (Ash of Butea monosperma), Arka Ksheera (Calotropis gigantic) and turmeric powder (Curcuma longa). This Ksharasutra was prepared as per the API guidelines and preserved in air tight tube. A patient of Pittaja predominant Prakruti with fistula-in ano having two external opening at 6 and 7 O’ clock position of anus was treated with application of Ksharasutra. The Palasha Ksharasutra prepared in Arkaksheera was applied in these two opening under spinal anesthesia. Then Ksharasutra was changed by weekly interval under local xylocaine jelly 2%. The length of thread was measured weekly and noted in the case to assess the unit cutting time (UCT). The unit cutting time (UCT) of first thread was 7.5 days/cm and second one had UCT 6.8 days/cm. During the treatment patient was doing his job regularly without hampering the quality of life. After 2 months patient was free from all symptoms of fistula with normal scar and without any complications. This case study demonstrated the utility of Palasha Ksharasutra prepared in Arkaksheera in multiple fistula-in ano.

scholarly journals The Influence of Different Plasma Cell Discharges on the Performance Quality of Surgical Gown Samples

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4329
Author(s):  
Atif H. Asghar ◽  
Ahmed Rida Galaly
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Exposure Time ◽  
Electrical Characteristics ◽  
Cathode Fall ◽  
Treatment Efficiency ◽  
Performance Quality ◽  
Surgical Gown ◽  
The One

An experimental study was performed on a low-density plasma discharge using two different configurations of the plasma cell cathode, namely, the one mesh system electrodes (OMSE) and the one mesh and three system electrodes (OMTSE), to determine the electrical characteristics of the plasma such as current–voltage characteristics, breakdown voltage (VB), Paschen curves, current density (J), cathode fall thickness (dc), and electron density of the treated sample. The influence of the electrical characteristics of the plasma fluid in the cathode fall region for different cathode configuration cells (OMSE and OMTSE) on the performance quality of a surgical gown was studied to determine surface modification, treatment efficiency, exposure time, wettability property, and mechanical properties. Over a very short exposure time, the treatment efficiency for the surgical gown surface of plasma over the mesh cathode at a distance equivalent to the cathode fall distance dc values of the OMTSE and for OMSE reached a maximum. The wettability property decreased from 90 to 40% for OMTSE over a 180 s exposure time and decreased from 90 to 10% for OMSE over a 160 s exposure time. The mechanisms of each stage of surgical gown treatment by plasma are described. In this study, the mechanical properties of the untreated and treated surgical gown samples such as the tensile strength and elongation percentage, ultimate tensile strength, yield strength, strain hardening, resilience, toughness, and fracture (breaking) point were studied. Plasma had a more positive effect on the mechanical properties of the OMSE reactor than those of the OMTSE reactor.

scholarly journals Monitoring and Debugging the Quality of Results in Approximate Programs

2015 ◽  
Vol 43 (1) ◽  
pp. 399-411 ◽  
Author(s):  
Michael Ringenburg ◽  
Adrian Sampson ◽  
Isaac Ackerman ◽  
Luis Ceze ◽  
Dan Grossman
Keyword(s):  
Quality Of Results

scholarly journals Curcumin: Modern Applications for a Versatile Additive

Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 519
Author(s):  
Florentina Monica Raduly ◽  
Valentin Raditoiu ◽  
Alina Raditoiu ◽  
Violeta Purcar
Keyword(s):  
Bacterial Infections ◽  
Natural Compound ◽  
Review Paper ◽  
Curcuma Longa ◽  
Antibacterial Properties ◽  
Point Of View ◽  
Nano Particles ◽  
Synergistic Activity ◽  
Quality Of Food

The recent development of several methods for extracting curcumin from the root of the plant Curcuma longa has led to intensified research on the properties of curcumin and its fields of application. Following the studies and the accreditation of curcumin as a natural compound with antifungal, antiviral, and antibacterial properties, new fields of application have been developed in two main directions—food and medical, respectively. This review paper aims to synthesize the fields of application of curcumin as an additive for the prevention of spoilage, safety, and quality of food. Simultaneously, it aims to present curcumin as an additive in products for the prevention of bacterial infections and health care. In both cases, the types of curcumin formulations in the form of (nano)emulsions, (nano)particles, or (nano)composites are presented, depending on the field and conditions of exploitation or their properties to be used. The diversity of composite materials that can be designed, depending on the purpose of use, leaves open the field of research on the conditioning of curcumin. Various biomaterials active from the antibacterial and antibiofilm point of view can be intuited in which curcumin acts as an additive that potentiates the activities of other compounds or has a synergistic activity with them.

scholarly journals Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids

Planta Medica ◽  
2016 ◽  
Vol 82 (06) ◽  
pp. 573-579 ◽  
Author(s):  
Jürgen Meins ◽  
Christian Artaria ◽  
Antonella Riva ◽  
Paolo Morazzoni ◽  
Manfred Schubert-Zsilavecz ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Botanical Dietary Supplements ◽  
Boswellic Acids ◽  
American Botanical

Research of H∞ Robust Control for the Giant Die Forging Hydraulic Press’s Synchronous Control System under the Uncertainty Coefficient

2012 ◽  
Vol 190-191 ◽  
pp. 819-824 ◽  
Author(s):  
Ying Jian Deng ◽  
Zhong Wei Liu
Keyword(s):  
Control System ◽  
Robust Control ◽  
Control Algorithm ◽  
Hydraulic Press ◽  
National Defense ◽  
Synchronous Control ◽  
Performance Quality ◽  
System Synchronization ◽  
Uncertainty Coefficient

The giant hydraulic die press is our country national defense and the infrastructure essential equipment, the synchronous control system is the essential device to the giant forging hydraulic press, its synchronization control performance quality is good or bad will directly determine the quality of the product. This article through the proof of the theorem, gives the specific steps to achieve H∞ robust control algorithm. The simulation results show that: this control strategy has good inhibition to the change of system parameters, robustness is very strong, can well eliminate the system synchronization error.

Sign in / Sign up

Export Citation Format

Share Document