scholarly journals Maternal Proinflammatory Adipokines Throughout Pregnancy and Neonatal Size and Body Composition: A Prospective Study

Author(s):  
Ellen C Francis ◽  
Mengying Li ◽  
Stefanie N Hinkle ◽  
Jinbo Chen ◽  
Jing Wu ◽  
...  

ABSTRACT BACKGROUND Increased maternal adiposity and inflammation have impacts on fetal growth. OBJECTIVES The purpose of this prospective study was to investigate the associations of three proinflammatory adipokines in pregnancy with neonatal anthropometry. METHODS In a sample of 321 U.S pregnant women from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singleton Cohort (NCT00912132), plasma interleukin (IL)-6, fatty acid binding protein-4 (FABP4), and chemerin were measured in plasma samples collected at 10–14, 15–26, 23–31, and 33–39 gestational weeks (GW). Generalized linear models were used to estimate associations of adipokines with neonatal weight, thigh and crown-heel length, and skinfolds at birth. Models adjusted for age, race/ethnicity, education, nulliparity, prepregnancy body mass index (BMI), and GW at blood collection. RESULTS At each time-point, higher IL-6 was associated with lower neonatal birthweight and thigh length. At 15–26 GWs, a one standard deviation pg/ml increase in IL-6 was associated with -84.46 g lower neonatal birthweight (95% Confidence Interval [CI]: -150.70, -18.22), -0.17 cm shorter thigh length (95% CI: -0.27, -0.07), -0.43 cm shorter crown-heel length (95% CI: -0.75, -0.10), and -0.75 mm smaller sum of skinfolds (95% CI: -1.19, -0.31), with similar associations at 23–31 and 33–39 GWs. There were no associations of FABP4 and chemerin with neonatal anthropometry. CONCLUSIONS Starting as early as 15 GWs, higher maternal IL-6 concentrations in pregnancy were associated with smaller neonatal birthweight, thigh and crown-heel length, and skinfolds. These data provide insight into the relevance of maternal inflammatory markers with neonatal anthropometry.

1989 ◽  
Vol 61 (02) ◽  
pp. 243-245 ◽  
Author(s):  
J G Thornton ◽  
B J Molloy ◽  
P S Vinall ◽  
P R Philips ◽  
R Hughes ◽  
...  

SummaryA panel of haemostatic tests was perfomed on 400 primiparous women at 28 weeks to test whether one or more could predict the development of pregnancy complications. Fifteen women subsequently developed pre-eclampsia with significant proteinuria and 13 delivered growth retarded infants. There were no significant differences between mothers in the pre-eclampsia group and 22 randomly selected controls. A stepwise logistic discriminant analysis of the data did not produce a significant model. In the growth retarded group only beta thromboglobulin levels were significantly lower than in the controls (p <0.05), although in the logistic discriminant analysis the inclusion of both beta thromboglobulin and fibrin degradation products led to a borderline significant improvement in fit of the model. We conclude that the haemostatic variables studied are not significantly changed at 28 weeks nor clinically useful predictors of either pre-eclampsia or fetal growth retardation.


Author(s):  
Giuseppe Rizzo ◽  
Ilenia Mappa ◽  
Pavjola Maqina ◽  
Victoria Bitsadze ◽  
Jamilya Khizroeva ◽  
...  

Author(s):  
Renata Paleari ◽  
Elena Succurro ◽  
Elvira Angotti ◽  
Elisabetta Torlone ◽  
Antonella Caroli ◽  
...  

1984 ◽  
Vol 150 (8) ◽  
pp. 965-972 ◽  
Author(s):  
Howard Minkoff ◽  
Amos N. Grunebaum ◽  
Richard H. Schwarz ◽  
Joseph Feldman ◽  
Marinella Cummings ◽  
...  

1996 ◽  
Vol 75 (4) ◽  
pp. 336-339 ◽  
Author(s):  
Lottie Skjöldebrand-Sparre ◽  
Eva Fridell ◽  
Margareta Nyman ◽  
Britta Wahren

2011 ◽  
Vol 32 (8) ◽  
pp. 1063-1070 ◽  
Author(s):  
Paola di Carlo ◽  
Amelia Romano ◽  
Alessandra Casuccio ◽  
Salvatore Cillino ◽  
Maria Gabriella Schimmenti ◽  
...  

2021 ◽  
Vol 41 (1) ◽  
pp. 38-39
Author(s):  
T. Maric ◽  
C. Kanu ◽  
D.C. Muller ◽  
I. Tzoulaki ◽  
M.R. Johnson ◽  
...  

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