scholarly journals Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study

2008 ◽  
Vol 29 (6) ◽  
pp. 741-747 ◽  
Author(s):  
Giovanni de Simone ◽  
John S. Gottdiener ◽  
Marcello Chinali ◽  
Mathew S. Maurer
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Left Ventricular Mass ◽  
Cardiovascular Health ◽  
Left Ventricular ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Previous Myocardial Infarction ◽  
Ventricular Mass

Carotid artery measures are strongly associated with left ventricular mass in older adults (A report from the cardiovascular health study)

1996 ◽  
Vol 77 (8) ◽  
pp. 628-633 ◽  
Author(s):  
Richard A. Kronmal ◽  
Vivienne-Elizabeth Smith ◽  
Daniel H. O'Leary ◽  
Joseph F. Polak ◽  
Julius M. Gardin ◽  
...  
Keyword(s):  
Older Adults ◽  
Carotid Artery ◽  
Left Ventricular Mass ◽  
Cardiovascular Health ◽  
Left Ventricular ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Ventricular Mass

scholarly journals Relation of Vitamin D and Parathyroid Hormone to Cardiac Biomarkers and to Left Ventricular Mass (from the Cardiovascular Health Study)

2013 ◽  
Vol 111 (3) ◽  
pp. 418-424 ◽  
Author(s):  
Adriana J. van Ballegooijen ◽  
Marjolein Visser ◽  
Bryan Kestenbaum ◽  
David S. Siscovick ◽  
Ian H. de Boer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Left Ventricular Mass ◽  
Cardiovascular Health ◽  
Left Ventricular ◽  
Cardiac Biomarkers ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Ventricular Mass

Abstract 2386: Asymptomatic Left Ventricular Systolic Dysfunction as a Predictor of Incident Heart Failure and Mortality in the Elderly: The Cardiovascular Health Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Jay Pandhi ◽  
Willem J Kop ◽  
John S Gottdiener
Keyword(s):  
Heart Failure ◽  
Cardiac Death ◽  
Cardiovascular Health ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Function ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Increased Risk

Left ventricular systolic dysfunction (LVSD) is an important predictor of outcomes in heart failure (HF) patients. Adverse effects of LVSD in individuals without heart failure, also known as asymptomatic LVSD (ALVSD), are not well established in the elderly. This study reports outcomes and evaluates the impact of LVSD in elderly subjects with ALVSD. The Cardiovascular Health Study is a multicenter longitudinal cohort study designed to assess cardiac risk factors and outcomes in a community-based population 65 years and older. The incidence of HF and mortality was evaluated in those with ALVSD with a median follow-up of 11.9 years. Cox regression was used, adjusting for demographics and cardiac risk factors, and stratified by severity of LVSD. Incident HF occurred in 39.2% of those with ALVSD vs. 22.8% in those without LVSD (RR = 1.51, CI = 1.25–1.84). Impaired ejection fraction (EF) (< 45%) was associated with more than twice the risk of incident HF than normal systolic function (RR = 2.21; CI 1.67–2.91). Individuals with borderline EF (45–55%) did not have an increased risk of incident HF (RR = 1.21; CI 0.94–1.56). The severity of LVSD was also predictive of mortality: borderline LVSD RR = 1.23 (CI 1.04–1.47) for all-cause mortality and 1.60 (CI 1.26–2.03) for cardiac death; impaired LVSD RR = 1.54 (CI 1.24–1.92) for all-cause mortality and RR = 2.12 (CI 1.60–2.81) for cardiac death. ALVSD is associated with increased risk of heart failure, death, and cardiac death when compared to normal systolic function. Furthermore, the degree of systolic dysfunction has a significant impact in predicting these outcomes in elderly individuals with ALVSD.

Abstract MP11: Association of Sick Sinus Syndrome with Incident Cardiovascular Disease and Mortality: the Atherosclerosis Risk in Communities Study and Cardiovascular Health Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Alvaro Alonso ◽  
Paul N Jensen ◽  
Faye L Lopez ◽  
Lin Y Chen ◽  
Bruce M Psaty ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Cardiovascular Health ◽  
Sick Sinus Syndrome ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Incident Cases ◽  
The Impact

Background: Sick sinus syndrome (SSS) is a disorder characterized by symptomatic dysfunction of the sinoatrial node. Despite being relatively frequent and a major indication for pacemaker implantation (PMI), the impact of SSS on the risk of other cardiovascular diseases (CVD) and mortality is unclear. Thus, we assessed whether SSS incidence was associated with mortality and CVD in two community-based studies. Methods: We included 19,893 men and women age 45 and older enrolled in the Atherosclerosis Risk in Communities (ARIC) study and the Cardiovascular Health Study (CHS), without pacemaker and free of atrial fibrillation (AF) at baseline. Incident cases of SSS were adjudicated after review of medical charts from hospitalizations with a 427.81 ICD-9 code. Ascertainment of incident CVD (heart failure, myocardial infarction, stroke, AF, PMI) and mortality was done according to standard validated protocols. The association between SSS and the selected outcomes was assessed using age, sex, and race-standardized rates and multivariable Cox models adjusted for potential confounders. Results: During a mean follow-up of 17 years, 213 incident SSS events were identified and validated (incidence = 6 events per 10,000 person-years). Age, sex, and race-standardized rates for each of the outcomes in those with and without SSS are presented in the Table. Overall, individuals with SSS had higher rates of mortality and CVD. These differences were still present, though weakened, after adjustment for baseline cardiovascular risk factors (Table, Model 2). After additional adjustment for incident CVD (Model 3), SSS was no longer associated with higher mortality, myocardial infarction or stroke, but an association with heart failure, AF and PMI remained. Conclusion: Individuals who develop SSS are at increased risk of death and incident CVD. Their management should incorporate comprehensive cardiovascular prevention in addition to symptom relief. The mechanisms underlying these associations warrant further investigation.

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