scholarly journals Obese Body Mass Index in late-life as a protective factor for Mild Cognitive Impairment, Dementia and Death

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 638-638
Author(s):  
Ginny Natale ◽  
Yun Zhang ◽  
Douglas Hanes ◽  
Sean Clouston
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Protective Factor ◽  
High School Graduates ◽  
Vigorous Physical Activity ◽  
Late Life ◽  
Survival Models ◽  
Time To Event ◽  
Death Time ◽  
Severity Of Dementia

Abstract Objective: The goal of the current study was to estimate the hazards of conversion from unimpaired to mild cognitive impairment (MCI) to probable dementia and death for underweight, normal, overweight and obese older adults in an aging cohort where the timing of examinations may be associated with the severity of dementia. Methods: We analyzed six waves of the National Health and Aging Trends Study (NHATS); a longitudinal aging cohort. Participants were classified into mutually exclusive cognitive statuses: cognitively unimpaired, MCI, probable dementia and death. Time-to-event ratios and cognitive transitions were examined with multistate survival models accounting for misclassification. BMI was computed from height and weight measurements and expressed in kg/m2 and categorized into underweight, normal, overweight and obese. Results: Participants (n=6,078) were 77 years old, on average, and the majority were white, females and high school graduates. About one third (32.68%) of the sample has normal BMI, one third is overweight (35.59%), the rests are obese (26.41%) or underweight (5.33%). After adjusting for the effects of diabetes, CVD, vigorous physical activity, age and race/ethnicity, the protective effect of obesity in late-life against developing dementia (HR=0.44; 95%CI[0.29-0.67]) and dying from dementia (HR=0.63; 95%CI[0.42-0.95). Discussion: Prior research shows the risk of dementia associated with obesity at older ages is either attenuated or reversed. Our findings support a protective factor of obesity in late-life against conversion to dementia and death.

scholarly journals Multi-Component Intervention Program on Habitual Physical Activity Parameters and Cognitive Function in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial

2021 ◽  
Vol 18 (12) ◽  
pp. 6240
Author(s):  
Min-Ki Jeong ◽  
Kyung-Won Park ◽  
Je-Kwang Ryu ◽  
Gwon-Min Kim ◽  
Hyun-Hun Jung ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Intervention Program ◽  
Vigorous Physical Activity ◽  
Cognitive Intervention ◽  
Habitual Physical Activity ◽  
Disease Assessment ◽  
Digit Symbol Substitution Test

Age-related dementia refers to a state in which someone experiences multiple cognitive function impairment due to degenerative brain disease, and which causes difficulties in their daily life or social life. Dementia is the most common and serious obstacle in later life. Early intervention in the case of patients who are in the mild cognitive impairment (MCI) stage among the high-risk group can maintain and improve their cognitive function. The purpose of the current trial is aimed at investigating the association between a multi-component (exercise with cognitive) intervention program and habitual physical activity parameters on cognitive functions in MCI patients. Neuropsychological cognitive and depression assessments were performed by neuropsychologists according to normalized methods, including the Korean mini-mental State examination (K-MMSE) and modified Alzheimer’s disease assessment scale-cognitive subscale (ADAS-Cog) and cognitive assessment tool (attention, processing speed), and the Korean version of the geriatric depression scale (SGDS-K), both at baseline and at a 12 weeks follow-up. The 12-week multi-component intervention improved cognitive function and habitual physical activity parameters in patients with MCI relative to controls. A multi-component intervention program for patients with MCI is considered to be an effective method of dementia prevention by improving global (ADAS-Cog) and frontal (trail-making test, digit symbol substitution test) cognition and habitual physical activity parameters such as moderate to vigorous physical activity and step count. In addition, it is important to encourage habitual physical activities to ensure that exercise intervention strategies are carried out at the duration and intensity required for improving physical and cognitive wellbeing and obtaining health benefits.

scholarly journals MRI-Based Classification Models in Prediction of Mild Cognitive Impairment and Dementia in Late-Life Depression

2017 ◽  
Vol 9 ◽  
Author(s):  
Aleksandra K. Lebedeva ◽  
Eric Westman ◽  
Tom Borza ◽  
Mona K. Beyer ◽  
Knut Engedal ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Late Life ◽  
Classification Models ◽  
Late Life Depression

Depression and mild cognitive impairment – Comorbidity and/or continuum?

2016 ◽  
Vol 33 (S1) ◽  
pp. S190-S191
Author(s):  
G. Sobreira ◽  
M.A. Aleixo ◽  
C. Moreia ◽  
J. Oliveira
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Late Life ◽  
The Elderly ◽  
Late Life Depression ◽  
Pubmed Database ◽  
Competing Interest ◽  
The Relationship

IntroductionDepression and mild cognitive impairment are common among the elderly. Half the patients with late-life depression also present some degree of cognitive decline, making the distinction between these conditions difficult.ObjectivesTo conduct a database review in order to understand the relationship between these entities, and treatment approaches.AimsTo create and implement clinical guidelines at our institution, to evaluate and treat elderly patients presenting with depression and mild cognitive impairment.MethodsA PubMed database search using as keywords “late life depression”, “depression”; “cognitive impairment”; “mild cognitive impairment” and “dementia” between the year 2008 and 2015.ResultsLate-life depression and cognitive impairment are frequent among the elderly (10–20%). Depression is also common in the early stages of dementia decreasing as the cognitive decline progresses. The causal relationship between these entities is not well understood and some authors advocate a multifactorial model (genetic risk factors; neuroendocrine changes; vascular risk factors) and the cognitive impairment of said changes is dependent on the individual's cognitive reserve. Regarding treatment of depression in patients with cognitive impairment, most authors advocate a stepped approach with watchful waiting and then, if symptoms persist, the introduction of pharmacotherapy and psychosocial intervention.ConclusionsThe relationship between cognitive impairment and depression is still not clear and probably multifactorial. The diagnosis of depressive symptoms in patients with severe cognitive impairment can be difficult and most forms of pharmacological treatment in this population are not beneficial, making it important to carefully evaluate the benefits of introducing new medication.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Late-life Physical Exercise, Neuropsychiatric Symptoms And The Risk Of Incident Mild Cognitive Impairment

2020 ◽  
Vol 52 (7S) ◽  
pp. 339-340
Author(s):  
Janina Krell-Roesch ◽  
Jeremy A. Syrjanen ◽  
Maria Vassilaki ◽  
Alexander Woll ◽  
Walter K. Kremers ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Physical Exercise ◽  
Neuropsychiatric Symptoms ◽  
Late Life
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