scholarly journals Outcomes of SARS-CoV-2 infected pregancies after medically assisted reproduction

2021 ◽  
Author(s):  
◽  
Baris Ata ◽  
Luca Gianaroli ◽  
Kersti Lundin ◽  
Saria Mcheik ◽  
...  
Keyword(s):  
Data Collection ◽  
Assisted Reproduction ◽  
Current Data ◽  
University Hospital ◽  
Human Reproduction ◽  
Selective Reporting ◽  
Online Data ◽  
Medically Assisted Reproduction ◽  
Data Registry ◽  
The Impact

Abstract Study question What is the impact of SARS-CoV-2 infection on the outcome of a pregnancy after medically assisted reproduction? Summary answer Our results suggest that medically assisted reproduction (MAR) pregnancies are not differentially affected by SARS-CoV-2 infection compared to spontaneous pregnancies. What is known already Information on the effects of COVID-19 on pregnancy after MAR is scarce when women get infected during MAR or early pregnancy, even though such information is vital for informing women seeking pregnancy. Study design, size, duration Data from SARS-CoV-2 affected MAR pregnancies were collected between May 2020 and June 2021 through a voluntary data collection, organised by the European Society of Human Reproduction and Embryology (ESHRE). Participants/materials, setting, methods All ESHRE members were invited to participate to an online data collection for SARS-CoV-2-infected MAR pregnancies. Main results and the role of chance The dataset includes 80 cases from 32 countries, including 67 live births, 10 miscarriages, 2 stillbirths and 1 maternal death. An additional 25pregnancies were ongoing at the time of writing. Limitations, reasons for caution An international data registry based on voluntary contribution can be subject to selective reporting with possible risks of over- or under-estimation. Wider implications of the findings The current data can be used to guide clinical decisions in the care of women pregnant after MAR, in the context of the COVID-19 pandemic. Study funding/competing interest(s) The authors acknowledge the support of ESHRE for the data registry and meetings. JT reports grants or contracts from Sigrid Juselius Foundation, EU and Helsinki University Hospital Funds, outside the scope of the current work. The other authors declare that they have no conflict of interest.

scholarly journals Cancer Risk in Children and Young Adults (Offspring) Born after Medically Assisted Reproduction: A Systematic Review and Meta-Analysis

J ◽  
2019 ◽  
Vol 2 (4) ◽  
pp. 430-448
Author(s):  
Manuela Chiavarini ◽  
Andrea Ostorero ◽  
Giulia Naldini ◽  
Roberto Fabiani
Keyword(s):  
Cancer Risk ◽  
Health Outcomes ◽  
Childhood Cancer ◽  
Assisted Reproduction ◽  
Meta Analysis ◽  
Cancer Data ◽  
Medically Assisted Reproduction ◽  
Increased Risk ◽  
Risk Of Cancer ◽  
The Impact

Many studies have investigated the relationship between medically assisted reproduction (MAR) and health outcomes, particularly cancer, in the offspring. This meta-analysis investigated the association between MAR and childhood cancer. Data sources were PubMed, Scopus, and Web of Science up until June 2018. From the selected studies, we extracted the cancer risk estimates of the exposure of interest (MAR, assisted reproductive technology—ART, and in fitro fertilization—IVF). We conducted the meta-analysis using a random effects model. The outcomes of interest were childhood cancers, classified according to the international classification of childhood cancer (ICCC-3). In our meta-analysis (18 cohort and 15 case-control studies) the overall cancer risk was significantly increased in children conceived by MAR, ART, or IVF. MAR and ART significantly increased the risk for hematological tumors, hepatic tumors, and sarcomas (odds ratio (OR) 1.54; 95% CI 1.18–2.02 and OR 1.92; 95% CI 1.34–2.74, respectively). MAR increased acute myeloid leukemia risk (OR 1.41; 95% CI 1.02–1.95) and ART increased neural cancer risk (OR 1.21; 95% CI 1.01–1.46). Our results suggest an increased risk of cancer in children conceived by MAR. Further studies are needed to investigate the impact of fertility treatments, parental subfertility status, and their association on health outcomes in the offspring.

Stress and the impact on the outcome of medically assisted reproduction

2020 ◽  
Vol 248 ◽  
pp. 187-192 ◽  
Author(s):  
Minna Geisler ◽  
Sarah Meaney ◽  
John Waterstone ◽  
Keelin O’Donoghue
Keyword(s):  
Assisted Reproduction ◽  
Medically Assisted Reproduction ◽  
The Impact

Measuring the Impact of Motivations on Travelers’ Strategic Decisions in Different Traffic Conditions: Data Collection, Analysis, and Modeling

2018 ◽  
Vol 2672 (47) ◽  
pp. 171-181 ◽  
Author(s):  
Dong Pan ◽  
Samer H. Hamdar ◽  
John L. Campbell ◽  
Amir Farrahi
Keyword(s):  
Data Collection ◽  
Field Experiments ◽  
Travel Demand ◽  
Demand Management ◽  
Research Work ◽  
Mitigation Strategies ◽  
Strategic Decisions ◽  
Online Data ◽  
Surface Transportation ◽  
The Impact

Continued growth in travel demand and the corresponding congestion occurrence accentuates the need for active transportation and demand management (ATDM) for predictive rather than reactive congestion mitigation strategies. These strategies (applications) reduce demand and thus improve the performance of different surface transportation facilities. Earlier research work mainly utilized simulations and field experiments to suggest improvements to ATDM applications associated with pricing and/or provision of information to travelers; however, few such studies considered the dynamics of travelers’ motivations as an essential component in the performance of a given ATDM application. In other words, how travelers’ motivations change as a function of the ATDM applications’ characteristics remains largely unexplored. This study thus examines the theory of planned behavior (TPB) to analyze travelers’ motivations associated with different mode choices and captures and measures the corresponding dynamics of motivations when facing different surrounding circumstances and ATDM regimes. Utilizing a survey and an online data collection platform to estimate motivational patterns behind travelers’ mode choices, following and extending the TPB paradigm, the study concludes that: (a) travelers’ mode choices are primarily determined by intentions (motivations); (b) income and age are two additional characteristics that influence mode choices; (c) travelers’ reasoned choices are mainly attitude-oriented; and (d) different attitudinal aspects are accentuated or compromised along with the changes of travel conditions and ATDM applications.

scholarly journals Well-being of children born after medically assisted reproduction

2021 ◽  
Author(s):  
Alice Goisis ◽  
Mikko Myrskylä
Keyword(s):  
Assisted Reproduction ◽  
Psychosocial Development ◽  
Low Birthweight ◽  
Mental Health Problems ◽  
Later Life ◽  
Well Being ◽  
Single Embryo Transfer ◽  
Medically Assisted Reproduction ◽  
Increased Risk ◽  
The Impact

Abstract Background The increasing number and proportion of children born after medically assisted reproduction (MAR) has raised concerns and motivated research about the impact of MAR on the well-being and development of children. Objective We summarize existing studies on the well-being and development of children conceived through MAR. Materials and methods Review of existing studies. Results Children conceived through MAR are at increased risk of adverse birth outcomes such as low birthweight and preterm delivery compared to naturally conceived children. The higher rates of multiple births amongst MAR-conceived children continue to represent an important driving factor behind these disparities. Reassuringly, elective single embryo transfer (eSET)—which is associated with more favourable pregnancy outcomes among MAR-conceived children—is becoming more common. Despite the early life health disadvantages, the evidence on later life outcomes such as physical, cognitive and psychosocial development is generally reassuring. On average, MAR-conceived children show similar or better outcomes than naturally conceived children. The selected and advantaged socioeconomic characteristics of parents who conceive through MAR are likely to play an important role in explaining why, on average, MAR-conceived children perform better than naturally conceived children—particularly in terms of cognitive outcomes. In contrast, there is some evidence pointing to potentially increased risks of mental health problems among MAR-conceived children. Conclusion There is need for continued monitoring and longer follow-up studies on the well-being of these children in order to better understand whether their outcomes are similar to or different from those of naturally conceived children, and, if so, why.

scholarly journals Effect of the Air Filtration System Replacement on Embryo Quality in the Assisted Reproduction Laboratory

2018 ◽  
Vol 40 (10) ◽  
pp. 625-630
Author(s):  
Karine Poletto ◽  
Yanna de Lima ◽  
Mário Approbato
Keyword(s):  
Air Quality ◽  
Assisted Reproduction ◽  
Embryo Quality ◽  
Human Reproduction ◽  
Air Filtration ◽  
Live Births ◽  
Positive Effects ◽  
Filtration System ◽  
The Impact

AbstractImproving infrastructural conditions of the in vitro fertilization laboratory, such as the air quality, has profound positive effects on embryo culture. Poor environmental conditions reduce the rate of embryo formation and, therefore, of pregnancy. This review article presents important publications regarding the impact of air quality in human reproduction laboratories on embryo quality, pregnancy success, and live births. The studies demonstrate that the replacing the air filtration system improves significantly the environmental air quality, and, consequently, improves laboratory parameters, such as the fertilization rate, the number of blastocysts, the embryo implantation rate, and the number of live births. On the other hand, improving air quality decreases the number of abortions. Therefore, environmental parameters that improve embryo quality and increase healthy child birth rates must be the main targets for the assisted reproduction laboratory quality control.

scholarly journals Evidence for the Need to Standardize Data Collection on Patient Outcomes Across Adult Day Centers in the United States

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 618-618
Author(s):  
Tina Sadarangani ◽  
William Zagorski ◽  
Lydia Missaelides
Keyword(s):  
United States ◽  
Data Collection ◽  
Large Scale ◽  
The United States ◽  
Current Data ◽  
Assessment Tools ◽  
Nutritional Risk ◽  
Pool Data ◽  
Adult Day Centers ◽  
The Impact

Abstract Researchers’ ability to measure the impact of adult day centers (ADCs) on participants’ health has been hampered by a lack of large-scale data. We examined categories of data ADCs across the United States are collecting related to patients’ health and health outcomes with the idea of developing a future national cohort of centers. We distributed an electronic survey to ADCs in 50-states on current data collection efforts. Forty states were represented (N=250). Only 32% of ADCs collect patient level data for research and analysis. Vital signs, nutritional risk, falls, and activities of daily living data were most commonly collected. However, validated assessment tools were used in less than 50% of cases. Researchers’ ability to pool data on clinical outcomes among ADC users is limited by lack of data collection and use of uniform outcome measures across ADCs. Standardizing data collection is critical to strengthening ADC programs and demonstrating their effectiveness.

Endometrial injury for patients with endometriosis and polycystic ovary syndrome undergoing medically assisted reproduction: current data and a protocol

2018 ◽  
Vol 35 (1) ◽  
Author(s):  
Charalampos Siristatidis ◽  
Ioannis Rigos ◽  
Vasilios Pergialiotis ◽  
Vasilios Karageorgiou ◽  
Nikolaos Christoforidis ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Assisted Reproduction ◽  
Immune Cell ◽  
Positive Impact ◽  
Polycystic Ovary ◽  
Current Data ◽  
Ovary Syndrome ◽  
Medically Assisted Reproduction ◽  
Endometrial Injury ◽  
Published Evidence

Abstract We propose a study protocol capable of improving clinical outcomes following medically assisted reproduction (MAR) in infertile women with endometriosis and polycystic ovary syndrome (PCOS). The proposed research derives from the published evidence on the positive impact from endometrial injury (EI) and the beneficial nature of the intervention towards improved implantation rates. We primarily refer to the cluster of events and hypotheses, such as the mechanical cascade, the inflammatory response per se, the events accompanying wound healing, the immune cell recruitment and protein involvement, alterations in gene expression and the neo-angiogenesis theories, which have been previously investigated for this purpose. We are also exploring the possible problems in MAR cycles with negative outcomes in PCOS and endometriosis patients and we are proposing potential mechanisms on how this intervention might work. Our hypothesis states that the EI before the initiation of the MAR cycle can affect clinical pregnancy rates in patients with the aforementioned pathologies.

scholarly journals A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Mitko Madjunkov ◽  
Michal Dviri ◽  
Clifford Librach
Keyword(s):  
Pregnant Women ◽  
Assisted Reproduction ◽  
Assisted Reproductive Technologies ◽  
Clinical Manifestations ◽  
Reproductive Technologies ◽  
Mitigation Strategies ◽  
Human Reproduction ◽  
System Capacity ◽  
Canadian Perspective ◽  
The Impact

AbstractCurrently, the world is in the seventh month of the COVID-19 pandemic. Globally, infections with novel SARS-CoV-2 virus are continuously rising with mounting numbers of deaths. International and local public health responses, almost in synchrony, imposed restrictions to minimize spread of the virus, overload of health system capacity, and deficit of personal protective equipment (PPE). Although in most cases the symptoms are mild or absent, SARS-CoV-2 infection can lead to serious acute respiratory disease and multisystem failure. The research community responded to this new disease with a high level of transparency and data sharing; with the aim to better understand the origin, pathophysiology, epidemiology and clinical manifestations. The ultimate goal of this research is to develop vaccines for prevention, mitigation strategies, as well as potential therapeutics.The aim of this review is to summarize current knowledge regarding the novel SARS CoV-2, including its pathophysiology and epidemiology, as well as, what is known about the potential impact of COVID-19 on reproduction, fertility care, pregnancy and neonatal outcome. This summary also evaluates the effects of this pandemic on reproductive care and research, from Canadian perspective, and discusses future implications.In summary, reported data on pregnant women is limited, suggesting that COVID-19 symptoms and severity of the disease during pregnancy are similar to those in non-pregnant women, with pregnancy outcomes closely related to severity of maternal disease. Evidence of SARS-CoV-2 effects on gametes is limited. Human reproduction societies have issued guidelines for practice during COVID-19 pandemic that include implementation of mitigation practices and infection control protocols in fertility care units. In Canada, imposed restrictions at the beginning of the pandemic were successful in containing spread of the infection, allowing for eventual resumption of assisted reproductive treatments under new guidelines for practice. Canada dedicated funds to support COVID-19 research including a surveillance study to monitor outcomes of COVID-19 during pregnancy and assisted reproduction. Continuous evaluation of new evidence must be in place to carefully adjust recommendations on patient management during assisted reproductive technologies (ART) and in pregnancy.

Sign in / Sign up

Export Citation Format

Share Document