scholarly journals MO842SARS-COV-2 INFECTION AMONG PATIENTS RECEIVING MAINTENANCE HAEMODIALYSIS: SINGLE HAEMODIALYSIS CENTER EXPERIENCE FROM BANGLADESH

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Mohammad Mehfuz E Khoda ◽  
Muhammad Abdur Rahim ◽  
Ishrat Jahan Shimu ◽  
Md Golzar Hossain ◽  
Md Abul Mansur
Keyword(s):  
Blood Group ◽  
Virus Disease ◽  
Tertiary Care ◽  
Health Care Facilities ◽  
Care Hospital ◽  
Rt Pcr ◽  
Case Record ◽  
Maintenance Haemodialysis ◽  
Corona Virus ◽  
Increased Risk

Abstract Background and Aims Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infections emerged in Wuhan, China in December 2019 and rapidly became pandemic. Unfortunately, there is lack of evidence about the optimal management of corona virus disease-2019 (COVID-19) and even less is available in patients on maintenance haemodialysis. Patient receiving maintenance haemodialysis are at increased risk for infection by SARS-CoV-2 with poor outcome. So, the purpose of this study was to identify the incidence of SARS-CoV-2 infection among end-stage kidney disease (ESKD) patients on maintenance haemodialysis. Method A cross-sectional study was conducted at a haemodialysis unit of tertiary care hospital of Bangladesh from April to August 2020. All patients, who were on maintenance haemodialysis, twice or thrice weekly, were screened by reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV-2, irrespective of symptoms. All data were collected in case record forms and patients were followed-up over phone. Results During the study period, a total of 133 patients (males 70, 52.6%) were on regular maintenance haemodialysis in the study centre. Most patients were in 5th and 6th decades of life. Twenty-one (15.8%) patients tested positive for SARS-CoV-2 by RT-PCR with female (16, 76.2%) predominance. Eighteen (18/21, 85.7%) patients had symptoms suggestive of SARS-CoV-2 infection and rest three (3/21, 14.3%) patients were diagnosed during routine screening. Common presentations were fever (42.9%), cough (66.7%) and respiratory distress (66.7%) and most had multiple symptoms. The incidence of SARS-CoV-2 infection in blood group A was 8(38%) and blood group O was 8(38%). There were no significant differences of mortality rate among blood groups. Most patients (16/21, 76.2%) infected by SARS-CoV-2 were referred to COVID-dedicated hospitals, five (5/21, 23.8%) were shifted to intensive care unit (ICU). Outcome was poor; 17 (17/21, 89%) patients died in hospitals and four (4/21, 19%) patients became free of SARS-CoV-2 infection. Caregivers/relative of our patients acquired COVID-19 in course of disease. Conclusion One-sixth of patients on maintenance haemodialysis acquired SARS-CoV-2 infection with nearly ninety percent fatality rates. Despite having risk factors for severe infection by SARS-CoV-2, patients on dialysis must visit health care facilities. So, utmost care should be taken to reduce risk of COVID-19 among such vulnerable group of patients.

scholarly journals COVID-19 among patients with end-stage kidney disease on maintenance haemodialysis: single haemodialysis centre experience from Bangladesh

2020 ◽  
pp. 41-45
Author(s):  
Mohammad Mehfuz E Khoda ◽  
Muhammad Abdur Rahim ◽  
Ishrat Jahan Shimu ◽  
Md Golzar Hossain ◽  
Munmun Dev ◽  
...  
Keyword(s):  
Kidney Disease ◽  
General Hospital ◽  
Blood Group ◽  
Health Care Facilities ◽  
Care Hospital ◽  
Rt Pcr ◽  
End Stage Kidney Disease ◽  
Case Record ◽  
Maintenance Haemodialysis ◽  
End Stage

Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection emerged in Wuhan, China in December 2019 and rapidly became pandemic. Unfortunately, there is a lack of evidence about the optimal management of corona virus disease-2019 (COVID-19) and even less is available in patients on maintenance haemodialysis than general population. So, the purpose of this study was to identify the incidence of SARS-CoV-2 infection among end-stage kidney disease (ESKD) patients in a haemodialysis unit in tertiary care hospital of Bangladesh. Methods: A cross-sectional study was conducted at haemodialysis unit of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka, Bangladesh from April to August 2020. All patients, who were on maintenance haemodialysis, twice or thrice weekly, were screened by reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV-2, irrespective of symptoms. All data were collected in case record forms and discharged/referred patients were followed-up over phone. Results: During the study period, a total of 133 patients (males 70, 52.6%) were on regular maintenance haemodialysis in the study center. Most patients were in 5th and 6th decades of life. Twenty-one (15.8%) patients tested positive for SARS-CoV-2 by RT-PCR with female (16, 76.2%) predominance. Eighteen (18/21, 85.7%) patients had symptoms suggestive of SARS-CoV-2 infection and rest three (3/21, 14.3%) patients were diagnosed during routine screening. Common presentations were fever (42.9%), cough (66.7%) and respiratory distress (66.7%) and most had multiple symptoms. Blood group A (38%) and O (38%) showed the higher incidence of SARS-CoV-2 infection than blood group B and AB with equal mortality rate among them. Most patients (16/ 21, 76.2%) infected by SARS-CoV-2 were referred to COVID-dedicated hospitals, five (5/21, 23.8%) were shifted to intensive care unit (ICU) of BIRDEM General Hospital. Outcome was poor; 17 (17/21, 89%) patients died in hospitals and four (4/21, 19%) patients became free of SARS-CoV-2 infection. Caregivers/relative of four patients acquired COVID-19 in course of disease. Conclusion: One-sixth of patients on maintenance haemodialysis acquired SARS-CoV-2 infection with nearly ninety percent fatality rates. Despite having risk factors for severe infection by SARS-CoV-2, dialysis patient must visit health care facilities. So, utmost care should be taken to reduce risk of COVID-19 among such vulnerable group of patients. Birdem Med J 2020; 10, COVID Supplement: 41-45

scholarly journals ECG CHANGES IN PATIENTS WITH COVID-19 – A RETROSPECTIVE OBSERVATIONAL STUDY AT A TERTIARY CARE HOSPITAL IN CHENNAI

2021 ◽  
pp. 5-7
Author(s):  
A .Shaik Sulaiman Meeran ◽  
T. Balaji ◽  
P. Raja ◽  
Kiran Chandramohan
Keyword(s):  
Risk Factors ◽  
Observational Study ◽  
Virus Disease ◽  
Tertiary Care ◽  
P Wave ◽  
Retrospective Observational Study ◽  
Care Hospital ◽  
Icu Admission ◽  
Corona Virus ◽  
Increased Risk

Background:A global outbreak of corona virus disease, caused by severe respiratory corona virus 2, has emerged since December 2019. However electrocardiographic manifestations of patients with COVID-19 have not been fully described. We aim to investigate ECG characteristics in COVID-19 patients and risk factors of ICU admission Methods:This retrospective observational study included the patients with COVID-19 at the Government Kilpauk Medical College, Chennai between June 1st and 31st, 2020. Demographic, clinical and ECG characteristics were collected and comparison were made between ICU and non ICU admission groups. Logistic regression was used to identify risk factors of ICU admission Results:Among the 159 patients included ST-T abnormalities were the most common ECG feature followed by arrhythmias. Compared with non ICU group, the ICU group showed higher heart rate and P wave duration and was more frequently associated with CVD, ST-T abnormalities, arrythmias, QTc prolongation and pathological Q waves. ST-T abnormalities and history of CVD were associated with increased risk of ICU admission Conclusion:COVID-19 is frequently related to cardiovascular manifestations including ECG abnormalities and cardiovascular comorbidities. ST-T abnormalities and CVD at admission were associated with increased odds of ICU admission

“ASSOCIATION OF ABO & RH BLOOD GROUPS WITH HEPATITIS, HIV AND SYPHILIS INFECTIONS IN HEALTHY BLOOD DONORS AT TERTIARY CARE CENTRE”.

2021 ◽  
pp. 68-70
Author(s):  
Sonal Chitroda ◽  
Neha Patel ◽  
Pinal Solanki
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Tertiary Care ◽  
Blood Groups ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Group Type ◽  
Increased Risk ◽  
High Prevalence ◽  
Blood Group Type

Background: People from certain blood groups are more prone to develop infections transmitted by blood transfusion. In order to improve the management of such infections some hypothesis suggests that genetic predispositions like ABO and Rh blood groups would inuence the occurrence of such infections. Hence the present study aims to assess any possible associations of ABO & Rh blood groups with Hepatitis, HIV & syphilis infections in healthy blood donors. This was a retrospective study in heal Methods: thy blood donors of tertiary care hospital enrolled during years 2016 to 2020. Blood samples from total 34015 donors were screened for blood grouping & serology of HIV, Hepatitis & Syphilis. Result: Out of total donors only 171 donors were found positive for transfusion transmitted infections. Hepatitis B virus was found more prevalent compared to other infections. In ABO blood group type “B” and in Rh blood group type “Positive” was found more prevalent in donors. But it did not show any signicant association with transfusion transmitted infections. Conclusion: High prevalence of HBV infections in blood donors in present study point towards need of public health measures in general population. Undertaking further research to determine the special blood groups as increased risk for categorized donors is recommended.

scholarly journals Ocular manifestations in patients with corona virus disease (COVID-19)

2021 ◽  
Vol 8 (2) ◽  
pp. 32-37
Author(s):  
Ranjana Sharma ◽  
Bishnu Prasad Sharma ◽  
Keshav Raj Sigdel ◽  
Sudeep Adhikari ◽  
Sudesh Subedi ◽  
...  
Keyword(s):  
Virus Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Ocular Manifestations ◽  
Corona Virus ◽  
Ethical Approval ◽  
The Common ◽  
Common Manifestation

Introduction: Corona virus disease (COVID-19) has affected many subspecialties including ophthalmology. We aimed to determine the ocular manifestations of COVID-19 patients treated in a dedicated tertiary care hospital, in Nepal. Method: This was a descriptive cross-sectional study in hospitalized COVID-19 patients in Patan Hospital, Patan Academy of Health Sciences, Kathmandu, Nepal. Data were collected during 6 months from November 2020 to May 2021 to achieve a for a specified sample size of 90. Ophthalmological manifestations were recorded in the consenting participants. Ethical approval was obtained. Result: One or more ocular manifestations were seen in 3.4% of admitted COVID-19 patients. Bilateral diffuse red eyes was the most common manifestation. Conclusion: Bilateral diffuse red eye was the common ocular manifestation in admitted COVID-19 patients.

scholarly journals Association of ABO blood groups with dengue fever and its complications in a tertiary care hospital

2019 ◽  
Vol 11 (03) ◽  
pp. 265-269 ◽  
Author(s):  
Shivani Ravichandran ◽  
S. R. Ramya ◽  
Reba Kanungo
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Blood Group ◽  
Clinical Laboratory ◽  
Tertiary Care ◽  
Blood Groups ◽  
Control Group ◽  
P Value ◽  
Care Hospital ◽  
Case Record

Abstract CONTEXT: Dengue fever (DF) has been steadily increasing in India with outbreaks in certain areas taking the proportion of epidemics. Along with secondary dengue, several risk factors predispose to dengue hemorrhagic fever and dengue shock syndrome. Very few studies associating the relationship between dengue and its severity with ABO blood group have been documented. AIMS: The aim of this study was to determine the association between distribution of ABO Rh blood groups and DF and DF with thrombocytopenia. SETTINGS AND DESIGN: This was a retrospective descriptive study conducted at the clinical laboratory of the department of microbiology. MATERIALS AND METHODS: Dengue patients whose case record contained information on blood group were screened for details of blood group and confirmed dengue diagnosis. Randomly 384 case records were selected. These were divided into two groups; Group 1 included DF cases (platelet count >20,000) and Group 2 included DF cases with thrombocytopenia (platelet count <20,000). Control group consisted of patients other than dengue, whose blood grouping had been done; randomly 390 were selected and analyzed. STATISTICAL ANALYSIS USED: P value was calculated using the Chi-square test. Odds ratio were calculated using the Fisher's exact test. RESULTS: DF was higher in 23% of individuals with AB blood group as compared to 8.5% of controls (P = 0.0004), whereas patients with blood group O were significantly less affected with DF (P = 0.0048). Disease severity was not associated with any of the blood groups. CONCLUSIONS: Individuals with AB blood group are more prone to DF, whereas individuals with blood group O are less prone.

scholarly journals Clinical Characteristics of Children with Corona Virus Disease: Study in a Tertiary Care Hospital, Dhaka, Bangladesh

2021 ◽  
Vol 9 (2) ◽  
pp. 60-63
Author(s):  
Mohammed Rizwanul Ahsan ◽  
Probir Kumar Sarkar ◽  
Nabila Akand ◽  
Kinkar Ghosh ◽  
Maleeha Sheefa
Keyword(s):  
Clinical Characteristics ◽  
Tertiary Care Hospital ◽  
Virus Disease ◽  
Tertiary Care ◽  
Care Hospital ◽  
Corona Virus ◽  
Disease Study

scholarly journals COVID-19 among patients with pre-existing renal impairment: experience in a tertiary care hospital of Bangladesh

2020 ◽  
pp. 23-28
Author(s):  
Muhammad Abdur Rahim ◽  
Tabassum Samad ◽  
Ishrat Jahan ◽  
Md Mashud Alam ◽  
Talha Sami Ul Haque ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Case Fatality ◽  
Kidney Injury ◽  
Cross Sectional Study ◽  
Electrolyte Imbalance ◽  
Care Hospital ◽  
Rt Pcr ◽  
Cross Sectional ◽  
Increased Risk ◽  
Polymerase Chain

Background: Patients with chronic kidney disease (CKD) are at increased risk for infection because of immunosuppressed state. CKD is an independent risk factor for poor outcome in coronavirus disease 2019 (COVID-19). This study was designed to describe clinical and laboratory parameters of COVID-19 patients with preexisting CKD. Methods: This cross-sectional study was conducted in the Department of Nephrology, BIRDEM General Hospital from July to December 2020. Hospitalized adult patients with CKD not yet on dialysis, who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcriptase polymerase chain reaction (RT-PCR), irrespective of symptoms were included in this study. RT-PCR negative cases were excluded. Results: Total patients were 40 (mean age 58.3 years, 52.5% male). Common comorbidities were diabetes mellitus (92.5%), hypertension (67.5%) and ischaemic heart disease (27.5%). Fever, cough, shortness of breath, headache and fatigue were common presenting features. Nearly one-fifth had no COVID-related symptoms. Lymphopenia and high inflammatory markers (ESR, CRP) were common. Sixteen patients were complicated by acute kidney injury, four patients required haemodialysis and 23 had electrolyte imbalance. Most cases were mild to moderate; most were transferred to COVID-dedicated hospitals or discharged with home isolation protocols. Three patients required intensive care unit shifting and two patients died. Conclusion: Most CKD patients had comorbid conditions. Clinical presentation was typical in most cases. Case fatality rate was higher than Bangladeshi statistics. Birdem Med J 2020; 10, COVID Supplement: 23-28

scholarly journals Real Time-PCR (RT-PCR) Positivity for SARS-CoV-2 in Suspected COVID-19 Patients Presented in a Tertiary Care Hospital

2020 ◽  
pp. 67-70 ◽  
Author(s):  
Sarmistha Biswas ◽  
Khan Abul Kalam Azad ◽  
Mohammad Mahfuzul Hoque ◽  
Syed Ghulam Mogni Mowla ◽  
Sultana Shahana Banu ◽  
...  
Keyword(s):  
Virus Disease ◽  
Tertiary Care ◽  
Early Period ◽  
High Rate ◽  
World Health ◽  
Care Hospital ◽  
Rt Pcr ◽  
College Hospital ◽  
Cross Sectional ◽  
Male Predominance

Introduction: Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a newly emergent virus. World Health Organization declared COVID-19 as pandemic on March 11, 2020 for its rapid spreading. Not only to diagnose the disease (confirm case) but also to control and contain the transmission; test, trace and isolation are fundamental. RT-PCR for SARS-CoV-2 is used to detect and diagnose COVID-19 which started in Dhaka Medical College Hospital (DMCH) on 2nd April 2020. In this study we described our observation of RT-PCR done in patients presented in DMCH in the first month after starting the test. Methods: This observational, cross sectional study was done to find out the rate of RT-PCR positivity in suspected COVID -19 patients presented to DMCH from 2nd April to 3rd May, 2020 by the Department of Medicine in association with the Department of Virology. Data was collected from the registry book of the Department of Virology. The rate of RT-PCR for SARS-CoV-2 positivity among the suspected COVID-19 patients and demographical variable was observed. Results: Among the total studied patients (n=3206), 58.8% (n=1886) was male and mean age was 37.7(±14.38784) years. RT-PCR for SARS- CoV-2 was positive in 26.9% (n=864). Mean age was higher in patients positive for test (39.6± 15.9 year vs. 37±14.4 year). Male predominance was more marked in patients with positive PCR test (68.4 vs. 55.9). Conclusion: High rate of positivity of RT PCR for SARSCoV- 2 among the suspected patient for COVID 19 indicated high disease burden and transmission in this highly populated area in the early period of pandemic which should be considered as was alarming. J Bangladesh Coll Phys Surg 2020; 38(0): 67-70

scholarly journals Microbiological profile of COVID-19 patients admitted in a tertiary care hospital Mathura, Uttar Pradesh, India

2021 ◽  
Vol 9 (5) ◽  
pp. 1403
Author(s):  
Anju Rani ◽  
Varuna Gupta ◽  
Kandhakumari Gandhi ◽  
Ashok Kumar Dhanvijay
Keyword(s):  
Antibiotic Susceptibility ◽  
Virus Disease ◽  
Tertiary Care ◽  
Automated System ◽  
Malarial Parasite ◽  
Care Hospital ◽  
Diagnostic Challenge ◽  
Igg Antibody ◽  
Microbiological Profile ◽  
Corona Virus

Background: The pandemic due to severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) has drawn worldwide worst effect with diagnostic challenge. Every investigation has its own importance for diagnosis, care, treatment and for management of corona virus disease-2019 (COVID-19) patients. Here this prospective study aimed to investigate the microbiological profile, prevalence of co-infection, and antibiotic susceptibility pattern of patients with confirmed SARS-CoV-2.Methods: A total of 336 samples were processed in COVID laboratory, Department of Microbiology. An array of serological investigations was done by rapid card screening test. C-Reactive protein (CRP) was analyzed by nephelometer. Blood culture was done by automated system and urine culture on Cystine-Lactose-Electrolyte-Deficient (CLED) Agar. Antibiotic susceptibility tests were done by Kirby Bauer disc diffusion method.Results: Out of 336 samples tested 76%were male and 24%were female. All samples tested were negative for HIV, HBsAg, HCV, syphilis, malarial parasite. CRP and Typhi -dot with IgM and IgG antibody were positive in 89.28% and 11.42% respectively. About 27% of COVID-19 patients showed bacterial and fungal co-infections. The most prevalent organisms were MR-CoNS (26%), K. pneumoniae (19%) and less prevalent were P. aeruginosa (6%) and A. baumannii (4%).  C. albicans (11%) was the only isolated fungi. All gram positive isolates were 100% sensitive to Linezolid and vancomycin, among gram negative isolates, 100% were sensitive to colistin and polymyxin B.Conclusions: Microbiological investigation for presence of other co-infecting agents among patients with COVID-19 infection should be considered, and prompt treatment should be carried out accordingly.

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